DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30440 and Mcf2l

DIOPT Version :9

Sequence 1:	NP_610172.1	Gene:	CG30440 / 35496	FlyBaseID:	FBgn0050440	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	XP_006253478.1	Gene:	Mcf2l / 117020	RGDID:	619782	Length:	1280	Species:	Rattus norvegicus

Alignment Length:	1071	Identity:	284/1071 - (26%)
Similarity:	442/1071 - (41%)	Gaps:	276/1071 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 IQSRADRIARIETCGIRTTHLQPETQILKPVTEPNETRFDQHS-PDWLFKNSR--------IGDV 218
            |..|.|:...::...:|.....|....|..|..|  |.|.|.: .|..||.:|        :..:
  Rat   204 IDRRQDKWTSVKASVLRIAASFPANLQLVLVLRP--TGFFQRTLSDIAFKFNRDEFKMKVPVMML 266

  Fly   219 SNSSKLSACNSELPPEEYKGRTL-YHDTKFDCAYIKNRRPLITTESKMSITEAEHPQTKYTDIKY 282
            |:..:|.....:....|..|.|| |..:::.|.........:..:....:.:|...:...|::..
  Rat   267 SSVPELHGYIDKSQLTEDLGGTLDYCHSRWLCHRTAIESFALMVKQTAQMLQAFGTELAETELPN 331

  Fly   283 DYKTCSISQGLHQNK----------------AFLNKVPPSKQSKPFHSVDYDYYEN---IQKLHL 328
            |.::.|:....|..|                :.|..:.........|||:.|..:|   :::| |
  Rat   332 DVQSTSLVLSAHTEKKAKVKEDLQLALTEGNSILESLREPLAESIVHSVNQDQLDNQATVKRL-L 395

  Fly   329 SKESERQIRDNGDPNDLQNFLKKNLIKATTNELLKAAAQSTKKCNIDLERKLNDLNIKEEDHTSN 393
            ::.:|.:..       ...|..|:..|......|:...|..::....|:      ::.::.....
  Rat   396 TQLNETEAA-------FDEFWAKHQQKLEQCLQLRHFEQGFREVKTALD------SMSQKIAAFT 447

  Fly   394 DSGNSYKNDPYL------------VSMSKINSCKF------------IRSYNRDCETIFPTGDH- 433
            |.|||..:..:|            |::.|..:...            :.|.:..||.:....||
  Rat   448 DVGNSLAHVQHLLKDLTTFEEKSSVAVDKARALSLEGQQLIENRHYAVDSIHPKCEELQHLCDHF 512

  Fly   434 -SDLNEFRKSFMPQSVDLLSSASVSLSSCD-----------GSCLNKDSI------------CGS 474
             |::.. |:..:.:|::|.|....|:...|           ..|.::|..            .|:
  Rat   513 ASEVTR-RRDLLSKSLELHSLLETSMKWSDEGIFLLASQPVDKCQSQDGAEAALQEIEKFLETGA 576

  Fly   475 EEDCCECN----EYQCIATPPNELSKDCLNAVEEGVFCNTEYDD--FH----------------- 516
            |....|.|    ||:||      |::|.|..|:: ||...|..:  ||
  Rat   577 ENKIQELNKIYKEYECI------LNQDLLEHVQK-VFQKQESTEEMFHRRQASLKKLAAKQTRPV 634

  Fly   517 -------ENLTSSCCCS-GSFCDDDGCSYLDEGLSVDIKSKNVQSLHESGTDEKLSRKTILLART 573
                   |.||.|...| ||:...:..|  .||                   ..|.|.....|::
  Rat   635 QPVAPRPEALTKSPSPSPGSWRSSENSS--SEG-------------------NALRRGPYRRAKS 678

  Fly   574 EDTNDVTQGISDGTTYFTGSLNITHLPKSNEIFKKPQDPEMQRHRRGHILKELFETEKIYVNEIA 638
            |.:..     ..|.|..||                 ::.|.....|.|::.||.:||:.||.|:.
  Rat   679 EMSEP-----RQGRTSSTG-----------------EEEESLAILRRHVMNELLDTERAYVEELL 721

  Fly   639 SILKGYYDRLKSDESA---PASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTERVALCFVK 700
            .:|:||...:.:...|   ...||.|.|:||||:.|||.|||.:||::||:||...|.|..||::
  Rat   722 CVLEGYAAEMDNPLMAHLISTGLQNKKNILFGNMEEIYHFHNRIFLRELESCIDCPELVGRCFLE 786

  Fly   701 RRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQRITKYQLLLK 765
            |.::| |:|..||||..|||.|.....|. .||:|||..|.|||.|.:|||||||||||||||||
  Rat   787 RMEEF-QIYEKYCQNKPRSESLWRQCSDC-PFFQECQKKLDHKLSLDSYLLKPVQRITKYQLLLK 849

  Fly   766 DLLLFTDNDSCRNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGELLMQDSFQVWIESKK 830
            ::|.::.:.....:|:.||..:|.:||.||||||.|:|||:.|:|...|:||||.||.||.:.||
  Rat   850 EMLKYSKHCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKK 914

  Fly   831 DIR-----LRMKPKRRHIFLYQKSLLLCKQTSKS--GYNKS-SYQFKSDVKMSQIGLTESVSGDA 887
            ...     .|.||.:||:||::|::|.||:..::  ||.|: ||.:|..:.|:.:|:||:|.||.
  Rat   915 GHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMTAVGITENVKGDT 979

  Fly   888 KRFEVWLKGRQEVYTLQASTIGVKEMWVAEIKRVLFNQLEKLKGDQIARYNIRHQSLWQKSSCEA 952
            |:||:|...|:|||.:||.|..:|..||.||::||.:||      |..|...:|::|.|..|...
  Rat   980 KKFEIWYNAREEVYIIQAPTPEIKAAWVNEIRKVLTSQL------QACREASQHRALEQSHSLPL 1038

  Fly   953 P-------------NITHCSLRRTE--CFE------------------LPLNDSNRN-------- 976
            |             |:.....|:|:  |.|                  :|.:.|..:
  Rat  1039 PTPASTSPTKGSTRNVKKLEDRKTDPLCLEGCVSSSLPKPPEKGKDDAVPSSTSESSALSRKRFT 1103

  Fly   977 ----TNIRSEKTCLSD-------QNIVNGP-------------SVQDQHEKNSWSS-----DCSD 1012
                .|::.:|...:.       ..:.:.|             |::...|...|||     :.||
  Rat  1104 LQGLANLKGQKASPTSPDKKAKRHEVKSDPTPFGLRGWSKTSHSLEAPEEDGGWSSAEELINSSD 1168

  Fly  1013 IDEDETINP---------ILM--QKTGQPKL 1032
            .:||..:.|         :||  :|.|...|
  Rat  1169 AEEDGGVGPRKLVPGKYTVLMDGEKGGSDTL 1199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	83/176 (47%)
		PH-like	802..925	CDD:302622	58/130 (45%)
		PH	829..922	CDD:278594	42/100 (42%)
Mcf2l	XP_006253478.1	SEC14	145..290	CDD:214706	20/87 (23%)
		SPEC	421..623	CDD:238103	41/215 (19%)
		RhoGEF	702..879	CDD:238091	84/178 (47%)
		PH_Dbs	886..1017	CDD:269934	58/130 (45%)
		PH	900..1014	CDD:278594	50/113 (44%)
		SH3_DBS	1184..1236	CDD:212791	5/16 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	157	1.000	Domainoid score	I4065
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001442
OrthoInspector	1	1.000	-	-		otm44888
orthoMCL	1	0.900	-	-		OOG6_102562
Panther	1	1.100	-	-	O	PTHR22826
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X905
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.870