Protein Alignment CG30440 and ARHGEF25

DIOPT Version :10

• Sequence 1: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Sequence 2: NP_001104740.2
• Gene: ARHGEF25 / 115557
• HGNCID: 30275
• Length: 619
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 150/529 - (28%)
• Similarity: 245/529 - (46%)
• Gaps: 93/529 - (17%)

  Fly   431 GDHSDLNE---FRKSFMPQSVDLL-SSASVSLSSCDGSCLNKDSICGSEEDCCECNEYQCIATPP 491
            |||....|   ...:..|:|..:. |..|:|.|:..|.........|       .:...|...||
Human    54 GDHRRDREHEVLAGALQPESYSIAGSEGSISASAASGLAAPSGPSSG-------LSSGPCSPGPP 111

  Fly   492 NEL---------SKDCLNAVEEGVFCNTEYDDF----HENLTSSCCCSGSFCDDDGCSYLDEGLS 543
            ..:         ||.||:.       .||.|..    :||.                 .|:..|:
Human   112 GPVSGLRRWLDHSKHCLSV-------ETEADSGQAGPYENW-----------------MLEPALA 152

  Fly   544 VDIKSKNVQSLHESGTDEKLSRKTILLARTEDTNDVTQGISDGTTYFTGSLNITHLPKSNEIFKK 608
                           |.|:|...|:|....|...|.||...:.|        ::..|:|.|..||
Human   153 ---------------TGEELPELTLLTTLLEGPGDKTQPPEEET--------LSQAPESEEEQKK 194

  Fly   609 PQDPEMQRHRRGHILKELFETEKIYVNEIASILKGYYDRLKSDESAPASLQGKANVLFGNLNEIY 673
                 ....|..::|.||.||||:||:::..|::||...:.: :..|.||:|:..::|||:.:||
Human   195 -----KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAA-QGVPESLRGRDRIVFGNIQQIY 253

  Fly   674 SFHNDVFLKDLENCISVTERVALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQI 738
            .:|.|.||::|:.|:...:.:|..|:|...:.: :|..||||..:||.:.....|:  :|:|.:.
Human   254 EWHRDYFLQELQRCLKDPDWLAQLFIKHERRLH-MYVVYCQNKPKSEHVVSEFGDS--YFEELRQ 315

  Fly   739 GLGHKLPLGAYLLKPVQRITKYQLLLKDLLLFTDN---DSCRNELKNALDCMLIVLKCVNDSMHQ 800
            .|||:|.|...|:||||||.||||||||.|.:.:.   |:.  :|:.|::.|..|.|..||.|..
Human   316 QLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTA--DLEQAVEVMCFVPKRCNDMMTL 378

  Fly   801 ISITGFSGDLAKQGELLMQDSFQVWI-ESKKDIRLRMKPKRRHIFLYQKSLLLCKQTSKS--GYN 862
            ..:.||.|.|..||:||.||:|  |: |.:....|..:.:.|.:||:::.::..:.....  |..
Human   379 GRLRGFEGKLTAQGKLLGQDTF--WVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGT 441

  Fly   863 KSSYQFKSDVKMSQIGLTESVSGDAKRFEVWLKGRQ---EVYTLQASTIGVKEMWVAEIKRVLFN 924
            :..|.:|:.:|:|.:||..::.||..||.:..:|.:   :.|.|||:...:.:.|:..:.::|.:
Human   442 QPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILES 506

  Fly   925 QLEKLKGDQ 933
            |.:.|...|
Human   507 QRDFLNALQ 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	67/176 (38%)
		PH-like	802..925	CDD:473070	35/128 (27%)
ARHGEF25	NP_001104740.2	RhoGEF	203..373	CDD:459876	67/175 (38%)
		PH2_Kalirin_Trio_p63RhoGEF	378..520	CDD:270061	38/140 (27%)