DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30440 and Mcf2

DIOPT Version :9

Sequence 1:	NP_610172.1	Gene:	CG30440 / 35496	FlyBaseID:	FBgn0050440	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	XP_006527813.1	Gene:	Mcf2 / 109904	MGIID:	96932	Length:	1127	Species:	Mus musculus

Alignment Length:	941	Identity:	243/941 - (25%)
Similarity:	398/941 - (42%)	Gaps:	220/941 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 HSPDW-LFKNS---------RIGDVSNSSKLSACNSELP------PEEYKGRT-LYHDTKFDCAY 251
            || :| :|:|:         .:..:..|.......:|||      .|...||. .||       .
Mouse   271 HS-EWIIFRNAIEKFAVTVKEMAQMLQSFGTELAETELPQDILSIEEILAGRAERYH-------L 327

  Fly   252 IKNRRPLITTESKMSITEAEHPQTKYT---------DIKYDYKTCS--ISQGLHQNKAFLNKVPP 305
            :||....:|.|.|:.:...:.|.|:.|         .|..|::|..  ::| :|..:...:....
Mouse   328 LKNDLTAVTKEGKVLLMNLQVPATEETVSSSLECTQHINGDWQTIKKLLAQ-VHDMETAFDGFWE 391

  Fly   306 SKQSK-----PFHSVDYDYYENIQKLHLSKESERQIRD-NGDPNDLQNFLKK-NLIKATTNELL- 362
            ..|.|     .....:.|:.|.:.::......:|::.| .|:...::..||| .::...:.|||
Mouse   392 KHQLKMEQYLQLWKFEQDFQEAVTQVEFLLSQQRELGDITGNLAQVKQRLKKLEILDDKSQELLT 456

  Fly   363 ----------KAAAQS-------TKKCN-----------------IDLERKLNDLNIKEEDHTSN 393
                      |.|:..       .::||                 :.|.|......:.::.....
Mouse   457 KARIVILRGHKLASNHHYALDLICQRCNELRYLSDILVNEIRTKRVQLSRTFKVHRLLQQARQCC 521

  Fly   394 DSGN----SYKNDPYLVSMSKINSCKFIRSYNRDCETIFP--TGDHSDLN-EFRKSFMPQSVDLL 451
            |.|.    |...|.:   .:|.::.|.::..:...:...|  ..|...|. ||.....|:....:
Mouse   522 DQGECLLASQGMDKF---QTKEDAQKALQDVDNFLQMAMPFINYDIESLQYEFDVLLSPELKAQM 583

  Fly   452 SSASVSLSSCDGSCLNKDSICGSEEDCCECNEYQCIATPPNELSKDCLNAVEEGVFCNTE----- 511
            .:..:.|.:...:..|:.:.|.|                        |..|.||.|.|..
Mouse   584 QNIQLKLENIRSAFQNQQAGCKS------------------------LKEVPEGAFQNLVPASEN 624

  Fly   512 --------YDDFHENLTSSCCCSGSFCDDDGCSYLDEGLSVDIK-SKNVQSLHESGTDEKLSRKT 567
                    :...|..:              |.|:. :...:.:| .|:.:.:|        ::..
Mouse   625 VMRSRMIFFSPKHVGI--------------GYSFF-QACRIFLKVKKSWRQIH--------AQSN 666

  Fly   568 ILLARTEDTNDVTQGISDGTTYFTGSLNITHLPKSNEIFKKPQDPEMQRHRRGHILKELFETEKI 632
            :.:...||:.:..   ||.:.....||:|.                     :.|:|.||.:||:.
Mouse   667 VKVEAVEDSQEKN---SDQSPKLDNSLDIL---------------------KNHVLNELIQTERA 707

  Fly   633 YVNEIASILKGYYDRLKSDES---APASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTERV 694
            ||.|:.::|.||...:.:.:.   .|..|:.|.:|||||:.|||.|||::|:..||:|....|||
Mouse   708 YVRELFTVLLGYRSEMDNPQMFDLMPPLLRNKKDVLFGNMAEIYEFHNNIFMSRLEDCSDAPERV 772

  Fly   695 ALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQRITK 759
            ..||::|:|.| |:|:.||||..|||.:.....:. .||:|||..|.|:|.|.:|||||||||||
Mouse   773 GPCFLERKDDF-QMYAKYCQNKPRSELIWRKYSEC-AFFQECQRKLKHRLGLDSYLLKPVQRITK 835

  Fly   760 YQLLLKDLLLFTDNDSCRNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGELLMQDSFQV 824
            ||||||:||.::.......:||.|||.||.:||.|||||||.:|.|:.|::.:.|::::|.||.|
Mouse   836 YQLLLKELLKYSKEGEGTTKLKEALDSMLELLKSVNDSMHQTAINGYVGNINELGKMVLQGSFNV 900

  Fly   825 WIESKKDIR-----LRMKPKRRHIFLYQKSLLLCKQTSKSGYNKS---SYQFKSDVKMSQIGLTE 881
            |:..:|...     .|.||.:||:|||:|:::.||:..:||....   ||.||..:||..:|:||
Mouse   901 WLGHRKGATKMKDFARFKPMQRHLFLYEKAVMFCKRRFESGEGADRYPSYSFKHCLKMEDVGITE 965

  Fly   882 SVSGDAKRFEVWLKGRQEVYTLQASTIGVKEMWVAEIKRVLFNQLE----KLKGDQIARYNIRHQ 942
            .|.||.::||:....::|:|.:||..:.||.:|:.||:::|..|.|    |.:.||...   :.|
Mouse   966 HVKGDNRKFEIRYSEKEEIYIVQAPNVDVKMLWLKEIRKILVQQKELMTAKTQQDQALD---QDQ 1027

  Fly   943 SLWQKSSCE-APNITHCSLRRTECFELPLNDSNRNTNIRSEKTCLSDQNIV------------NG 994
            ...|:.:.| ..:...|     .|.|...|.:.....:......:..:...            ||
Mouse  1028 LFPQQQNAELCKSSPFC-----VCEETLFNATEAGAEVEQAGALIKVREAAVLAQAEASSAAWNG 1087

  Fly   995 --PSVQD-----QHEKNSWSSDCSDIDEDET 1018
              ||.:.     :|..|.:||: :|..||.|
Mouse  1088 MLPSAEGAAAIAEHSYNYFSSN-NDHGEDRT 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	84/176 (48%)
		PH-like	802..925	CDD:302622	47/130 (36%)
		PH	829..922	CDD:278594	37/100 (37%)
Mcf2	XP_006527813.1	SEC14	128..268	CDD:214706
		SPEC	408..599	CDD:351773	30/193 (16%)
		RhoGEF	694..871	CDD:238091	84/178 (47%)
		PH-like	878..1009	CDD:388408	47/130 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4108
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001442
OrthoInspector	1	1.000	-	-		otm42821
orthoMCL	1	0.900	-	-		OOG6_102562
Panther	1	1.100	-	-	LDO	PTHR22826
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X905
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.960