Protein Alignment CG30440 and VAV3

DIOPT Version :10

• Sequence 1: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Sequence 2: NP_006104.4
• Gene: VAV3 / 10451
• HGNCID: 12659
• Length: 847
• Species: Homo sapiens
• Alignment Length: 477
• Identity: 103/477 - (21%)
• Similarity: 199/477 - (41%)
• Gaps: 100/477 - (20%)

  Fly   559 TDEKLSRKTI-----------LLARTEDTNDVTQGISDGTTYFTGSLNITHLPKSNEIFKKPQDP 612
            |:|.::.:.|           |:...||..|...|..:|...:      ..|.|:.|. .:|:.|
Human   131 TEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVY------EDLMKAEEA-HQPKCP 188

  Fly   613 EMQRHRRGHILKELFETEKIYVNEIASILKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSFHN 677
            |  ...|...|.|:.:||:.|...:.||.|.:...||...:|     .:.:.:|.|:.|:...|.
Human   189 E--NDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTA-----AEFDSVFINIPELVKLHR 246

  Fly   678 DVFLKDLENCISVTER-VALCFVKRRDKFYQLYSFYCQNIQRS----EKLRETLVDTHMFFKECQ 737
            ::..:..::.::..:: :...|:..:::.. :|..||..::.:    :.:.:|..|..:..:||.
Human   247 NLMQEIHDSIVNKNDQNLYQVFINYKERLV-IYGQYCSGVESAISSLDYISKTKEDVKLKLEECS 310

  Fly   738 IGLGH-KLPLGAYLLKPVQRITKYQLLLKDLLLFTDNDSCRNELKNALDCMLIVLKCVNDSMHQI 801
            ....: |..|...|:.|:||:.||.|||::|:..|.:.:.:..||.|||.|..:.:.||
Human   311 KRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDAMKDLAQYVN------ 369

  Fly   802 SITGFSGDLAKQGELLMQ-DSFQVWIESKK-------------DIRLRMKPK----RRHIFLYQK 848
                   ::.:..|.|.: ..||:.||:..             :||:....|    .|||||:..
Human   370 -------EVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDL 427

  Fly   849 SLLLCKQTSKSGYNKSSYQFKSDVKMSQIGLTESVSGDAKRFEVWLKGRQEVYT-------LQAS 906
            ::::||   :.|.|   |:.|..:.:.|..:..:.:.| |..:.|..|...::|       ....
Human   428 AVIVCK---RKGDN---YEMKEIIDLQQYKIANNPTTD-KENKKWSYGFYLIHTQGQNGLEFYCK 485

  Fly   907 TIGVKEMWVAEIKRVLFNQLEKLKGDQIAR--YNIRHQSLWQKSSCEAPNITHCSLRRT-----E 964
            |..:|:.|:.:.:..|.|    ::.|....  ::.:..:..:.:||:   :....||.|     .
Human   486 TKDLKKKWLEQFEMALSN----IRPDYADSNFHDFKMHTFTRVTSCK---VCQMLLRGTFYQGYL 543

  Fly   965 CFELPLNDSNRNTNIRSEKTCL 986
            ||:         ...|:.|.||
Human   544 CFK---------CGARAHKECL 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	43/179 (24%)
		PH-like	802..925	CDD:473070	30/147 (20%)
VAV3	NP_006104.4	CH_VAV3	2..118	CDD:409113
		RhoGEF	193..369	CDD:238091	43/181 (24%)
		PH_Vav	383..506	CDD:269930	29/133 (22%)
		C1_VAV3	506..564	CDD:410419	12/63 (19%)
		Sufficient for interaction with ROS1. /evidence=ECO:0000269|PubMed:11094073	560..847
		SH3_VAV3_1	596..657	CDD:212914
		SH2_Vav3	666..768	CDD:198270
		SH3_VAV3_2	791..846	CDD:212911