DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30440 and Plekhg4

DIOPT Version :9

Sequence 1:	NP_610172.1	Gene:	CG30440 / 35496	FlyBaseID:	FBgn0050440	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	XP_006530585.2	Gene:	Plekhg4 / 102075	MGIID:	2142544	Length:	1235	Species:	Mus musculus

Alignment Length:	491	Identity:	134/491 - (27%)
Similarity:	225/491 - (45%)	Gaps:	72/491 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   517 ENLTSSCCCSGSFCDDDGCSYLDEGLSVDIK----SKNVQSLHESGTDEKLSRKTILLARTEDTN 577
            |.:...|.|:.:.|.|...: ||:.....:|    :.|..:|:........:...:..|.:.|.|
Mouse   647 EGIRQECRCAWAQCQDTWLA-LDQKREAALKPMPATNNTATLYVRRAPAVPTVPPLRKAYSFDRN 710

  Fly   578 ------DVTQGISDGTTYFTGSLNITHLPKSNEIFKKPQDPEM---------QRHRRGHILKELF 627
                  ||:   |.|  :....:...|.|::....:....|.:         ..:|...:|.|:.
Mouse   711 LGRHLQDVS---SRG--HCAAIVTDCHRPEARGGVRPRSSPPVPLSGSSDFRSPNRLQLVLAEMV 770

  Fly   628 ETEKIYVNEIASILKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTE 692
            .||:.||..:...::.|:..|...: .|..|:|:...|||||.::..||.:.||::||.|.....
Mouse   771 ATEREYVRALDYTIQNYFPELDRPD-VPQGLRGQRAHLFGNLEKLRDFHYNFFLRELEACTRHPP 834

  Fly   693 RVALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQRI 757
            |||..|::.|.:| .:|:.|.:|..||:.|....  .|.||||.|..||..|.|.:|||||:|.:
Mouse   835 RVAHAFLRHRVQF-GMYALYSKNKPRSDALMTNY--GHTFFKEKQQALGDHLDLASYLLKPIQHM 896

  Fly   758 TKYQLLLKDLLLFTDNDSC------RNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGEL 816
            :||.|||::|.     .:|      ...|:.|...:...|:..||.:...:|.|...:|.:||:|
Mouse   897 SKYALLLQELA-----RACGGPAQELGALQAAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQL 956

  Fly   817 LMQDSFQVWIESKKDIRLRMKPKRRHIFLYQKSLLLCK-QTSKSGYNKSSYQFKSDVKMSQIGLT 880
            :.||.|.|        |.......|.:||:::.||..| :...:|.:  .:.:|...||:.:|||
Mouse   957 VRQDEFTV--------RAGRHKACRRVFLFEELLLFSKPRRGPAGVD--IFTYKRSFKMADLGLT 1011

  Fly   881 ESVSGDAKRFEVWLKGR--QEVYTLQASTIGVKEMWVAEIKRVLFNQL---EKLKGDQIARYNIR 940
            |.......|||:|.:.|  ::::.||||.:..|:.|.|:|.|:|:.|.   ::::..::|...:.
Mouse  1012 ECCGESQLRFEIWFRRRKARDLFVLQASDVATKQAWTADISRLLWRQAVHNKEVRMAEMASMGVG 1076

  Fly   941 HQSLWQKSSCEAPNITHCSLRRTECFELPLNDSNRN 976
            .::.|.    .||:            |..:||.|.|
Mouse  1077 SKAFWD----IAPS------------EEAINDRNIN 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	61/179 (34%)
		PH-like	802..925	CDD:302622	40/125 (32%)
		PH	829..922	CDD:278594	29/95 (31%)
Plekhg4	XP_006530585.2	SEC14	230..351	CDD:417771
		SPEC	475..>626	CDD:413338
		RhoGEF	762..928	CDD:238091	60/174 (34%)
		PH_puratrophin-1	928..1063	CDD:270062	44/144 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810