Protein Alignment CG30440 and mcf2l

DIOPT Version :10

• Sequence 1: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Sequence 2: XP_012813354.1
• Gene: mcf2l / 100497730
• XenbaseID: XB-GENE-6042031
• Length: 1216
• Species: Xenopus tropicalis
• Alignment Length: 836
• Identity: 242/836 - (28%)
• Similarity: 381/836 - (45%)
• Gaps: 179/836 - (21%)

  Fly   272 HPQTKYTDIKYDYKTCSISQGLHQNKAFLNKVPPSKQSKPFHSVDYDYYEN---IQKLHLSKESE 333
            |..|:..:...|:...:::||..    .|||:...::..|.:.::.|..:|   :::|
 Frog   273 HAHTEKKEKMKDHLKIALTQGCD----ILNKIMEPRKENPEYRMNQDQLDNQTTVERL------- 326

  Fly   334 RQIRDNGDPNDLQNFLKKNLIKATTNELLKAAAQSTKKCNIDLERKLNDLNIKEEDHTSNDSGNS 398
                          .|:.|..:|..:|......|..::|   |:.:..:||.:|.. ||.| |.|
 Frog   327 --------------LLQLNETEAAFDEFWSKHEQKLEQC---LQLRHFELNFREIS-TSLD-GIS 372

  Fly   399 YKNDPYLVSMSKI-NSCKFIRSYNRD-CETIFPTGDHSDLNEFRKSFMPQSVDLLSSASVSLSSC 461
            .:    |.:.:.: |||.......:| |                 :|..:|.::|.:|...:.
 Frog   373 ER----LEAFTDVGNSCSHAEHILKDFC-----------------NFEVKSREVLQTAQNLVR-- 414

  Fly   462 DGSCLNKDSICGSEEDCCECNEYQCIATPPNELSKDCLNAVEEGVFCNTEYDDFHENL------- 519
            :|..|.|.:....:....:|:|.       ..|.....|.:::      ...:.|::|
 Frog   415 EGDQLIKSNHYAVDSILPKCDEI-------GHLCDSISNTIQQ------RRQNLHKSLELHRHLE 466

  Fly   520 -TSSCCCSG----------SFCDDDGCS--------YLDEGLSVDIKS----------------- 548
             |...|..|          .|...||..        :|:.|..:.:|.
 Frog   467 KTMKWCDEGIFLLASQPVDKFQSQDGAEAALQEITRFLETGTDITMKDLAFILKMYNSILTPELQ 531

  Fly   549 -------KNVQSLHESGTDEKLSRKTILLARTEDTNDVT---QGISDGTT------------YFT 591
                   :..:|:.|.....|.|.:.:...:|.....|.   :.||...|            |.:
 Frog   532 EHVNKVYQKQESMQEMFEKRKGSLRKLAAKQTRPVQPVAPRPEAISKSPTSSPGLHRSSESRYSS 596

  Fly   592 GSL--NITHLPKSNEI-------FKKPQDPEMQRHRRGHILKELFETEKIYVNEIASILKGYYDR 647
            ||:  .|.:....:|:       ....:|.|.....|.|::.||.|||:.||.|:.|:::||...
 Frog   597 GSIQRRINYRRAKSEVDGSQMRSTSVMEDEENLAVLRRHVMNELIETERAYVEELLSVIEGYAAE 661

  Fly   648 LKSD---ESAPASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTERVALCFVKRRDKFYQLY 709
            :.:.   :..|:.||.|.:|||||:.|||.|||.:||::||:.....|.|..||::|.:.| |:|
 Frog   662 MNNPLVMDLIPSVLQNKKDVLFGNMEEIYQFHNRIFLRELEHYRDYPELVGRCFLERMEDF-QIY 725

  Fly   710 SFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQRITKYQLLLKDLLLFTDND 774
            ..||||..|||.|.....|. .||::||..|.|||.|.:|||||||||||||||||::|.::.|.
 Frog   726 EKYCQNKPRSESLWRQCSDA-AFFQDCQKKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSKNC 789

  Fly   775 SCRNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGELLMQDSFQVWIESK------KDIR 833
            ....:|:.||..:|.:||.||||||||:|||:.|:|.:.|:||||.||.||.|.|      ||:
 Frog   790 EGAEDLQEALASILGILKAVNDSMHQIAITGYEGNLHELGKLLMQGSFNVWTEHKKGHSKVKDL- 853

  Fly   834 LRMKPKRRHIFLYQKSLLLCKQTSKS--GYNKS-SYQFKSDVKMSQIGLTESVSGDAKRFEVWLK 895
            .|.||.:||:||::|::|.||:..::  ||.|: ||.:|..:.|..:|:||.|.||.::||:|..
 Frog   854 ARFKPMQRHLFLHEKAVLFCKKRDENGEGYEKAPSYSYKHSLNMMFVGITEYVKGDNRKFEIWYN 918

  Fly   896 GRQEVYTLQASTIGVKEMWVAEIKRVLFNQLEKLKGDQIARYNIRHQSLWQKSSCEAPNITHCSL 960
            .|:|||.:||.|..||..||.||::||.:|   ||..:.|.:   |:|....:|...|..:..|
 Frog   919 AREEVYIVQAPTTEVKATWVNEIRKVLTSQ---LKAHRDASH---HKSAEHANSLPTPLPSSTS- 976

  Fly   961 RRTECFELPL-NDSNRNTNIRSEKT---CLSDQNIVNGPSVQDQHEKNSWSSDCSD 1012
                    || |.|.:...:...||   ...|.::.:.|...::.:..:.:|..||
 Frog   977 --------PLRNKSGKIKKLEERKTEPLLNPDVSLTSVPKYLEKGKDGTVTSPTSD 1024

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	82/176 (47%)
		PH-like	802..925	CDD:473070	60/131 (46%)
mcf2l	XP_012813354.1	SEC14	77..222	CDD:214706
		SPEC	353..561	CDD:238103	40/245 (16%)
		RhoGEF	633..810	CDD:238091	83/178 (47%)
		PH_Dbs	817..948	CDD:269934	60/131 (46%)
		PTZ00108	<958..1104	CDD:240271	16/76 (21%)
		SH3_DBS	1118..1171	CDD:212791