DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30440 and mcf2

DIOPT Version :9

Sequence 1:	NP_610172.1	Gene:	CG30440 / 35496	FlyBaseID:	FBgn0050440	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	XP_031747179.1	Gene:	mcf2 / 100489667	XenbaseID:	XB-GENE-949776	Length:	1118	Species:	Xenopus tropicalis

Alignment Length:	1110	Identity:	284/1110 - (25%)
Similarity:	463/1110 - (41%)	Gaps:	321/1110 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 MTHYIHEGK------KAIMYRSSEPQIAARRNKKTRFVGNRRQLRNLSQPENSHKTSRSLCPDTA 90
            :.|||.|.:      ....||.|:..|.     :|...|....::.::|...|..|      :.|
Frog   174 LLHYIDEKQLTPEFGGTFDYRHSDWVIC-----RTAIEGFALTVKEIAQRLQSFGT------ELA 227

  Fly    91 KTE-PK-VYSLRFVLNKSEDKDYMSRLKAQNDFSQSSCLCNNLSHANTEAGAYQNDG-----ILK 148
            :|| |: |||:..:|....:|.:..:....:...:.|.|.|:|            ||     :.:
Frog   228 ETELPRDVYSIEHILAVRNEKYFQLKEGIMSVMREGSLLLNSL------------DGPTPTLVEE 280

  Fly   149 GQ--RDHSDFLTAAGGIQSRADRIARIETC--GIRTTHLQPETQILKPVTEPNETRFDQHSPDWL 209
            ||  ..:.|:.|    :|....::..:||.  |....|.....|.|:.:      :|:||
Frog   281 GQHCEKNGDWET----VQRLLAQLHEMETAFDGFWEKHQLKMEQYLELL------KFEQH----- 330

  Fly   210 FKNSRIGDVSNSSKLSACNSELPPEEYKGRTLYHDTKFDCAYIKNRRPLITTESKMSITEAEHPQ 274
                 ..::.|.::......|..|:.....:.......|.:.::.|...:...|:|.|
Frog   331 -----FEELKNGTEYLRSQHENIPDTGDNASEVRQRLMDLSNLEERSQELIRRSQMVI------- 383

  Fly   275 TKYTDIKYDYKTCSISQGLHQNKAFLNKVPPSKQSKPFHSVDYDYYENI------QKLHLSKESE 333
                              ||.::.               :|::.|..|:      :..|:|....
Frog   384 ------------------LHGHQL---------------AVNHHYALNLICQQCNELRHMSDVLS 415

  Fly   334 RQIRDNGDPNDLQNFLKKNLIKATTNELLKAAAQSTKKCNIDLERKLNDLNIKEEDHTSNDSGNS 398
            .:|:            :|....:||.||.....|.|:.|                     |.|
Frog   416 EEIK------------RKYAQLSTTLELHTRLQQVTECC---------------------DKG-- 445

  Fly   399 YKNDPYLVSMSKINSCKFIRSYNRDCETIFPTGDHS---DLNEFRK------SFMPQSVD----- 449
                .|.::..:::.|:            ...|.|.   ||.:|.:      ::.||:::
Frog   446 ----AYFLANQQMDKCQ------------SKEGAHKALLDLEKFLENASPYSTYDPQTLEYEYES 494

  Fly   450 -LLSSASVSLSSCDGSCLNKDSICGSEEDCC------ECNEYQCIATPPNELS--KDCLNAVEEG 505
             |.......:.|......|...:..:.:.|.      :....|.:|..|...|  |..|.:.:.|
Frog   495 ILTDELKTQIQSVHNKIENVRGLFENRQSCLKKLADKQARPVQLVAPRPETPSRAKSPLFSPKHG 559

  Fly   506 VFCNTEYDDFHENLTSSCCCSGSFCDDDGCSYLDEGLSVDI------------KSKNVQSLHESG 558
            :       ||:..|.                     .|.||            .::.::.:|:
Frog   560 M-------DFNSTLK---------------------FSFDITLPGKRTTRKIQTTRKIEVMHD-- 594

  Fly   559 TDEKLSRKTILLARTEDTNDVTQGISDGTTYFTGSLNITHLPKSNEIFKKPQDPEMQRHRRGHIL 623
            ..|:.:...:.::.:||:.|:.                                      :||::
Frog   595 YQERRNSLQLFISESEDSLDIL--------------------------------------KGHVI 621

  Fly   624 KELFETEKIYVNEIASILKGYYDRLKSD---ESAPASLQGKANVLFGNLNEIYSFHNDVFLKDLE 685
            .||.|||:|||.|:.::|.||...:::.   ...|.||:...|:||||:.|||.|||.|||:.||
Frog   622 HELIETERIYVEELYTVLLGYRSEMENPAMMHFMPQSLRNMKNILFGNMPEIYEFHNKVFLQSLE 686

  Fly   686 NCISVTERVALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYL 750
            :||...|:|..||::||:.| |:|..||||..||:.|.....|: :||:|||..|.|||.|.:||
Frog   687 SCIEAPEKVGFCFLERREDF-QMYEKYCQNKPRSDSLWRQFSDS-VFFQECQKKLDHKLALDSYL 749

  Fly   751 LKPVQRITKYQLLLKDLLLFTDNDSCRNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGE 815
            ||||||:||||||:|:||.::.|.....||:.|||.||.:||.||||||||:|||::||:.:.|.
Frog   750 LKPVQRLTKYQLLIKELLKYSSNADGAEELQEALDSMLDLLKSVNDSMHQIAITGYNGDINELGR 814

  Fly   816 LLMQDSFQVWIESKKDIR-----LRMKPKRRHIFLYQKSLLLCKQTSK--SGYNKS-SYQFKSDV 872
            :|||.||.|||..||...     .|.||.:||:|||:::|:.||:..:  .|::|: ||.||..:
Frog   815 ILMQGSFSVWITHKKGATKMKELARFKPMQRHLFLYERALVFCKKREEHGDGHDKTPSYSFKHIL 879

  Fly   873 KMSQIGLTESVSGDAKRFEVWLKGRQEVYTLQASTIGVKEMWVAEIKRVLFNQLEKLKG------ 931
            ||:.:|:||:|.||:::||:|..||:|||.:||.|...|..|:.||:::|..|.|.:||
Frog   880 KMNAVGITENVKGDSRKFEIWYSGREEVYIVQAQTSEQKTAWLNEIRKILTRQQEHMKGTVQKQK 944

  Fly   932 -----DQIARYNIRHQSLWQKSSCEAPNITHCSLRRTECFELPLNDSNRNTNIRSEKTCLSDQNI 991
                 ||::.....::...|:||..:..                |||..::.|..|...||.  :
Frog   945 PNASTDQLSFSPQMNERKPQRSSVSSEE----------------NDSESSSPIMLEGLNLSP--L 991

  Fly   992 VNGP--------SVQDQHEKNSWSSD-----CSDIDEDETINPILMQKTGQPKLL--WNRSSSHQ 1041
            ...|        ||:.....:.||::     |||.:|::|:    ....|:.|.|  ..:..|..
Frog   992 HKSPRGWTGMSQSVEICEGLDGWSNNPCSCPCSDTEEEDTV----QLSPGKYKALADCKKRGSED 1052

  Fly  1042 VFIKS 1046
            :.:|:
Frog  1053 ILVKN 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	88/176 (50%)
		PH-like	802..925	CDD:302622	57/130 (44%)
		PH	829..922	CDD:278594	42/100 (42%)
mcf2	XP_031747179.1	SEC14	52..192	CDD:214706	4/17 (24%)
		SPEC	326..522	CDD:413338	41/296 (14%)
		RhoGEF	619..794	CDD:238091	88/176 (50%)
		PH-like	801..932	CDD:418428	57/130 (44%)
		SH3_DBS	1038..1092	CDD:212791	4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	171	1.000	Domainoid score	I3697
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001442
OrthoInspector	1	1.000	-	-		otm47931
Panther	1	1.100	-	-	LDO	PTHR22826
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X905
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.100