DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30440 and mcf2l.2

DIOPT Version :9

Sequence 1:	NP_610172.1	Gene:	CG30440 / 35496	FlyBaseID:	FBgn0050440	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	XP_031757909.1	Gene:	mcf2l.2 / 100380200	XenbaseID:	XB-GENE-5959163	Length:	1291	Species:	Xenopus tropicalis

Alignment Length:	1028	Identity:	295/1028 - (28%)
Similarity:	436/1028 - (42%)	Gaps:	285/1028 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 LKGQRDHSDFLTAAGGI-----------QSRADRIARIETCGIRTT--HLQPETQILKPVTEPN- 197
            |.|..|.|...|..||.           ::..:..|::    ::||  :||.....|.....||
Frog   228 LHGYIDKSQLTTELGGTLEYSHSQWIHHRTAIESFAQV----VKTTAQNLQTFGTSLAETELPND 288

  Fly   198 ----ETRFDQHSPDWL-FKNSRIGDVSNSSKLSACNSE---------LPPEEYKGRTLY------ 242
                |.....|:...: .||.....:.....|.:|..|         |.|:|.:.....
Frog   289 VLCTEELLQSHTEQQISLKNDLNLAMQQGGTLLSCIKEPVSKDPSYKLNPDEVENMATVERLLAQ 353

  Fly   243 --------------HDTKFD-CAYIKN-----RRPLITTESKMSITEAEHPQTKYTDI-----KY 282
                          |..|.: |..:::     |...:|.:..|.|      |..:.||     :.
Frog   354 LDETEKAFGHFWSRHQLKLEQCLQLRHFEHDFRELKLTLDGLMEI------QAAFADIGDSVSRV 412

  Fly   283 DYKTCSISQGLHQNKAFLNKVPPSKQSKPFHSVDYDYYENIQKLHLSKESER----QIRDNGDPN 343
            :|....:.:...:.:..|.|.       ..|::..|  :.||..|.:.:|.|    ::|...|
Frog   413 EYLIKELKKLEEKGQGMLEKA-------QLHALHGD--QLIQNNHYAVDSIRPKCIELRRICD-- 466

  Fly   344 DLQNFLKKNL-IKATTNELLK---------------AAAQSTKKCNID--LERKLNDLNIKEED- 389
            |..|..||.. |.|.:.||.:               .|:|:..||...  .|..|.|:.:..|.
Frog   467 DFTNETKKKYDILAKSLELHQQLDEANKWCEDGIYLLASQAVDKCQSQEGAESALRDIELFIESS 531

  Fly   390 ---HTSNDSGNSYKNDPYLVSMSKINSCKFIRS-------YN-----------RDCETIFPTGDH 433
               ..||.:....|.|..|....|.|..|.::.       :|           :....|.|...|
Frog   532 RGHQLSNPTDFYNKYDAILTLEIKANVQKVLQKVADVQEMFNKRQASLKKLAAKQTRPIQPVAPH 596

  Fly   434 SDLNEFRKSFMPQSVDLLSSASVSLSSCDGSCLNKDSICGSEEDCCECNEYQCIATPPNELSKDC 498
            .:.:..|.|  |::| ..:|.|.:..:.|..|:                       ||..||:..
Frog   597 PESSPKRSS--PKTV-RPTSLSTTRRAADVPCV-----------------------PPKSLSEAD 635

  Fly   499 LNAVEEGVFCNTEYDDFHENLTSSCCCSGSFCDDDGCSYLDEGLSVDIKSKNVQSLHES---GTD 560
            |:...            :...|.:                  |:.:::       :||:   ||.
Frog   636 LSRKR------------NNKKTKA------------------GIKIEV-------MHEASQGGTS 663

  Fly   561 EKLSRKTILLARTEDTNDVTQGISDGTTYFTGSLNITHLPKSNEIFKKPQDPEMQRHRRGHILKE 625
                 :|::::.:|:                   |::                   .|:.||:.|
Frog   664 -----RTLVMSESEE-------------------NLS-------------------SRKSHIINE 685

  Fly   626 LFETEKIYVNEIASILKGYYDRLKSDES---APASLQGKANVLFGNLNEIYSFHNDVFLKDLENC 687
            |.|||::||.|:.|||:||...|::.|.   .|.:||....||||||:|||.||..:|||:||||
Frog   686 LIETERVYVEELQSILEGYASSLENPEMIGLIPVALQNNKEVLFGNLSEIYEFHKRIFLKELENC 750

  Fly   688 ISVTERVALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLLK 752
            |...:.:..||:||::.. |:|..||||..|||.:.....:: :||:|||..|.|||.|.|||||
Frog   751 IENADLLGTCFLKRKEDL-QIYEKYCQNKPRSEAIWRQCAES-IFFQECQRRLDHKLSLDAYLLK 813

  Fly   753 PVQRITKYQLLLKDLLLFTDNDSCRNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGELL 817
            |||||||||||||::|..:.|.....||:.||..:|.::|.||||||||:|||:.|||...|:||
Frog   814 PVQRITKYQLLLKEMLKCSKNSEGTAELEEALATVLDIIKSVNDSMHQIAITGYEGDLNDLGKLL 878

  Fly   818 MQDSFQVWIESK------KDIRLRMKPKRRHIFLYQKSLLLCK--QTSKSGYNKS-SYQFKSDVK 873
            ||.||.||.:.|      ||: .|.||.:||:|||.|:||.||  :.:..|:.|| ||.||..:|
Frog   879 MQGSFNVWTDHKKGHNKVKDL-ARFKPMQRHLFLYAKALLFCKKREENSEGHEKSQSYSFKHILK 942

  Fly   874 MSQIGLTESVSGDAKRFEVWLKGRQEVYTLQASTIGVKEMWVAEIKRVLFNQLEKLKGDQIARYN 938
            ||.:|:||:|.||.|:||||..||:|||.:|||||.:|.:||:||::||..|||
Frog   943 MSSVGITENVKGDNKKFEVWYNGREEVYIIQASTIELKNLWVSEIRKVLTGQLE----------- 996

  Fly   939 IRHQSLWQKSSCEAPNITHCSLRRTE-CFELPLNDSNRNTNIRSEKTCLSDQNIVNGPSVQDQHE 1002
                      :|...:..|  .|.|| .:..|:|.|   ...||.||..:.||....||::..::
Frog   997 ----------ACREASQLH--QRITESVYHAPMNSS---FIARSNKTSGNSQNKGELPSLEVSNK 1046

  Fly  1003 KNSWSSDCSDIDEDETINP--------ILMQKTGQPKLLWNRSSSHQVFIKSK 1047
            ||..||...  .:.:..||        .|.:|....:.|.||.:.|:...:.|
Frog  1047 KNRTSSPTG--RQKKADNPASHNLERSALARKRFTLQGLSNRRAPHKAESQEK 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	88/176 (50%)
		PH-like	802..925	CDD:302622	69/131 (53%)
		PH	829..922	CDD:278594	52/101 (51%)
mcf2l.2	XP_031757909.1	SEC14	101..246	CDD:214706	7/17 (41%)
		SPEC	377..579	CDD:238103	44/218 (20%)
		RhoGEF	679..856	CDD:238091	88/178 (49%)
		PH_Dbs	863..994	CDD:269934	69/131 (53%)
		SH3_DBS	1188..1242	CDD:212791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	171	1.000	Domainoid score	I3697
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001442
OrthoInspector	1	1.000	-	-		otm47931
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X905
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.000