DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30440 and arhgef25a

DIOPT Version :9

Sequence 1:	NP_610172.1	Gene:	CG30440 / 35496	FlyBaseID:	FBgn0050440	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	XP_009295232.1	Gene:	arhgef25a / 100331456	ZFINID:	ZDB-GENE-100728-4	Length:	732	Species:	Danio rerio

Alignment Length:	730	Identity:	188/730 - (25%)
Similarity:	324/730 - (44%)	Gaps:	125/730 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 LKKNLIKATTNELLKAAAQ-------STKKCNIDLERKLNDLNIKEEDHTS-----NDSGNSYKN 401
            |.||  :..|:|:|.|.|.       ..:|.|.|   .:..|::|:|..||     :..|.::::
Zfish     4 LPKN--QGRTDEILGAMADMLTSLAIPNQKWNSD---SIEHLSVKQERKTSQRPPWDTEGLNWED 63

  Fly   402 DPYLVSMSKINSCKFIRSYNRDCETIFPTGDHSDLNEFRKSFMPQSVDLLSSASVSLSSCDGSCL 466
                  ||: :|.:.:|..:| ..:....|....::....|..||:         |.||...|..
Zfish    64 ------MSR-DSLERVRRRDR-ANSYSAAGSEGSISTSVASLPPQA---------SGSSAPNSPG 111

  Fly   467 NKDSI------------------CGSEEDCCECNEYQCIATPPNELSKDCL---NAVEE------ 504
            ::.|:                  .||.:...:....:....||...|...|   .:.||
Zfish   112 SRRSVSTLKKWLTNPVRKLSAGAAGSAKGERQVRRLEGKPPPPPTRSSQELGSPQSTEEQFTILP 176

  Fly   505 GVFCNTEYDDFHENLTSSCCCSGSFCDDDGCSYLDEGLSVDIKSKNVQSLHESGTDEKLSRKTIL 569
            |:....|:.|   .|.:...|             |.||   ::|.:.||....|        :..
Zfish   177 GIDKELEWKD---GLPALGDC-------------DPGL---LQSYSFQSDSPQG--------STT 214

  Fly   570 LARTEDTNDVTQGISDGTTYFTGS-LNITHLPKSNEIFKKPQDPEMQRHRRGHILKELFETEKIY 633
            |.:|:.:...:|...|     .|| |...:..:|:......:|.:....:..::|.||.||||:|
Zfish   215 LGQTQISQCTSQQADD-----NGSVLMDDNSSQSSACADTEEDRKSALEKSMYVLNELIETEKLY 274

  Fly   634 VNEIASILKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTERVALCF 698
            |.::..|::||...: :.:..|..::||..::|||:::||.:|.|.||.:||.|::..:|:|..|
Zfish   275 VADLGLIVEGYMATM-NVKGIPEDMKGKDKIVFGNIHQIYDWHKDYFLAELEKCVAEPKRLAQLF 338

  Fly   699 VKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQRITKYQLL 763
            :|...:.: :|..||||..:||.:....::|  :|:|.:..|||:|.|...|:||||||.|||||
Zfish   339 IKHERRLH-MYVVYCQNKPKSEHIVSEYIET--YFEELKQQLGHRLQLNDLLIKPVQRIMKYQLL 400

  Fly   764 LKDL-LLFTDNDSCRNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGELLMQDSFQVWIE 827
            |||. ..:|.......||:.|::.|..|.|..||.|:...:.||.|.:..||:||.||:|.:
Zfish   401 LKDFHKYYTKAGMDTEELEKAVEVMCFVPKRCNDMMNVGRLQGFEGKITAQGKLLQQDTFTI--- 462

  Fly   828 SKKDIRLRMKPKRRHIFLYQKSLLLCKQTS-KSGYNKSSYQFKSDVKMSQIGLTESVSGDAKRFE 891
            :::|..:..:.|.|.:||:::.::..:... |.|::...|.||:.:|:|.:|:...|.||..||.
Zfish   463 TEQDSSILSRAKERRVFLFEQLVIFSEPIDRKKGFSLPGYIFKNSIKISCLGVEACVDGDPNRFA 527

  Fly   892 VWLKGRQEV---YTLQASTIGVKEMWVAEIKRVLFNQLEKLKGDQIARYNIRHQSLWQKS----- 948
            :..:|....   |.|.:|:..:...||:::.::|..|...|...|..   |.:|....||
Zfish   528 LTSRGADGSTVRYVLYSSSPNICMAWVSDVSQILETQRNFLNALQSP---IEYQRRESKSNSLGR 589

  Fly   949 SCEAPNITHCSLRRTECFELPLNDSNRNTNIRSEKTCLSDQNIVNGPSVQDQHEKNSWSSDCSDI 1013
            |.:.|......||......:   |.::...:||..|.|....:.:.....|..:..|     :.:
Zfish   590 SIKPPLSAVAGLRPHSSASI---DRHKLPCLRSCNTSLPSLYLPSQVPTDDHSQPES-----TPV 646

  Fly  1014 D---EDETINPILMQ 1025
            |   ..:|::|..:|
Zfish   647 DSRLNSQTVSPTHVQ 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	68/174 (39%)
		PH-like	802..925	CDD:302622	35/126 (28%)
		PH	829..922	CDD:278594	24/96 (25%)
arhgef25a	XP_009295232.1	SH3-RhoG_link	65..>150	CDD:293215	15/95 (16%)
		RhoGEF	263..434	CDD:279015	68/174 (39%)
		PH2_Kalirin_Trio_p63RhoGEF	438..577	CDD:270061	39/144 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910