DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30440 and mcf2l2

DIOPT Version :9

Sequence 1:	NP_610172.1	Gene:	CG30440 / 35496	FlyBaseID:	FBgn0050440	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	XP_021335410.1	Gene:	mcf2l2 / 100149630	ZFINID:	ZDB-GENE-100812-1	Length:	1284	Species:	Danio rerio

Alignment Length:	961	Identity:	281/961 - (29%)
Similarity:	418/961 - (43%)	Gaps:	237/961 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 ILKPVTEPNETRFDQ----------HSPDWLFK------NSRIGDVSN-----------SSKLSA 226
            :|||      :||.|          |..|:..|      || :.|:..           ...|..
Zfish   161 VLKP------SRFLQRAIADVSMRLHRDDFKLKVPIVMLNS-LSDLHGYIDKGQLTCDLGGTLDY 218

  Fly   227 CNSELPPEEYKGRTLYHDTKFDCAYIKNRRPLITTESKM------SITEAEHPQ----TK----- 276
            |:|:         .::|.|.     |:|....:.:.::|      .:.|.|.|.    ||
Zfish   219 CHSQ---------WIHHRTA-----IENFALTVKSTAQMLQQFGTDLAETELPNDVQCTKDLLIT 269

  Fly   277 YTDIKYDYKTCSISQGLHQNKAFLNKVPPSKQSKPFHSVDYDYYEN---IQKLHLSKESERQIRD 338
            :|: |:|.....:...:.|....|:.:.........|.::.|..||   :::| |::..|.:
Zfish   270 HTE-KHDKLKDELKLAVKQGNTLLSCIKDQATKAESHILNPDEVENQTTVERL-LAQLDETE--- 329

  Fly   339 NGDPNDLQNFLKKNLIKATTNELLKAAAQSTKKCNIDLERKLNDLNIKEEDHTSNDSGNSYKNDP 403
                |..:.|..::.:|......|:...|..|:..:.|:      .:.|.....:|:|:......
Zfish   330 ----NAFEQFWSRHHLKLEQCLQLRHFEQDFKEVKVSLD------GLSEALLGLSDTGDCVARVE 384

  Fly   404 YLVSMSKINSCKFIRSYNRDC-ETIFPTGDHSDLNEFRKSFMPQSVDLLSSASVSLSSCDGSCLN 467
            .|     :...|.:....::| |.......|.|             .|:.|...::.|....|:.
Zfish   385 QL-----LGELKTLEDKAQECLEKAQLQAQHGD-------------QLIQSNHYAIDSIRPKCVE 431

  Fly   468 KDSICGSEEDCCECNEYQCIATPPNELSK--DCLNA-VEEGVF---------CNTE------YDD 514
            ...||  ::...|..:.:.:.|...|:.|  |.:|. .|.||:         |.|:      ..|
Zfish   432 LRRIC--DDFSNEAKKKRDVLTKSLEILKRIDEVNQWCESGVYLLASQAVDRCQTQEGAEAALQD 494

  Fly   515 FHENLTSSCCCSGSFCDDDGCSYLDE-------GLSVDIKSK---------NVQSLHES--GTDE 561
            ....:.::        .:...|:|.|       .||..:|||         :||.:.|.  .:.:
Zfish   495 IERYMKTA--------KEQQLSHLKELNNQYEVVLSELLKSKVQTALKTLNDVQEMFEKRHASLK 551

  Fly   562 KLS----------------------------------RKT------------ILLARTEDTNDVT 580
            |||                                  |||            ..||:.::.....
Zfish   552 KLSTKQTRPVQPVAPRPESSPKRPSPKIPHPTPPTSHRKTTDNSSTNRQPSDAELAKRKNIRKAK 616

  Fly   581 QGISDGTTYFTGSLNITHLPKSNEIFKKPQDPEMQRHRRGHILKELFETEKIYVNEIASILKGYY 645
            .||.....:..|....:|:..:||      ..|...:||.||:.||.|||::||.|:.||::||.
Zfish   617 GGIKIEVMHEGGQGGSSHILMNNE------TEESLSNRRSHIMNELIETERLYVEELQSIIEGYA 675

  Fly   646 DRLKSDE---SAPASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTERVALCFVKRRDKFYQ 707
            ..|...|   ..|.||:.|..||||||.|||.||..:|||:|||.....|.|..||:||:::. |
Zfish   676 AALDDPELIYLIPPSLENKKEVLFGNLPEIYQFHQKIFLKELENSAEKPELVGTCFLKRKEEL-Q 739

  Fly   708 LYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQRITKYQLLLKDLLLFTD 772
            :|..||||..|||.|.....|: |||:|||..|.|||.|.|||||||||||||||:||::|..:.
Zfish   740 IYEKYCQNKPRSEALWRQCGDS-MFFQECQKRLDHKLSLDAYLLKPVQRITKYQLMLKEMLKCSK 803

  Fly   773 NDSCRNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGELLMQDSFQVWIESK------KD 831
            |.....||:.|...:|.::|.||||||||:||||.|.|...|:||||.||.||.:.|      ||
Zfish   804 NPEGTAELEEAQATVLDIIKSVNDSMHQIAITGFEGSLNDLGKLLMQGSFNVWTDHKKGHSKVKD 868

  Fly   832 IRLRMKPKRRHIFLYQKSLLLCKQTSK--SGYNKS-SYQFKSDVKMSQIGLTESVSGDAKRFEVW 893
            : .|.||.:||:|||.|.:|.||:..:  .|:.|| ||.||..:||..:|:||:|.||.|:||:|
Zfish   869 L-ARFKPMQRHLFLYHKMILFCKKREEMTDGHEKSPSYSFKHSLKMGSVGITENVKGDIKKFEIW 932

  Fly   894 LKGRQEVYTLQASTIGVKEMWVAEIKRVLFNQLEKLK-GDQIARYNIRHQSLWQKSSCEAPNITH 957
            ..||:|||.:||.::.||..||:||::||.:|||..: ..|:      ||.:.:       ||.|
Zfish   933 YNGREEVYIIQAPSMDVKNTWVSEIRKVLTSQLEACREASQL------HQKITE-------NIYH 984

  Fly   958 CSLRRTECFELPLNDSNR-NTNIRSEKTCLSDQNIVNGPSVQDQHEKNSWS 1007
            ..:|......|..:||:. .|..|.     ||    :||:::.:....|.|
Zfish   985 APMRNMRKTALRQSDSSSPETGYRR-----SD----SGPNMRQKRADTSSS 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	89/176 (51%)
		PH-like	802..925	CDD:302622	64/131 (49%)
		PH	829..922	CDD:278594	47/101 (47%)
mcf2l2	XP_021335410.1	SEC14	77..217	CDD:214706	12/62 (19%)
		SPEC	348..554	CDD:238103	43/239 (18%)
		RhoGEF	649..826	CDD:238091	90/178 (51%)
		PH_Dbs	833..964	CDD:269934	64/131 (49%)
		Mating_C	932..>1122	CDD:315419	37/117 (32%)
		SH3_DBS	1188..1242	CDD:212791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	168	1.000	Domainoid score	I3781
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001442
OrthoInspector	1	1.000	-	-		otm24801
orthoMCL	1	0.900	-	-		OOG6_102562
Panther	1	1.100	-	-	O	PTHR22826
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X905
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.910