Protein Alignment CG30440 and si:dkey-65j6.2

DIOPT Version :9

• Sequence 1: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Sequence 2: XP_009295405.2
• Gene: si:dkey-65j6.2 / 100148904
• ZFINID: ZDB-GENE-090313-319
• Length: 1588
• Species: Danio rerio
• Alignment Length: 1327
• Identity: 273/1327 - (20%)
• Similarity: 449/1327 - (33%)
• Gaps: 437/1327 - (32%)

  Fly    14 EEDSDTRNSTYVPKMELLMTHYIHEGKKAIMYRSSEPQIAARR--------NKKTRFV---GNR- 66
            :.:.:.|:|.:    |::...::..|||...:....|::..||        :.|::..   |:|
Zfish   390 QSNQEDRSSYF----EMIPRLHVVPGKKTTTFGLVSPKLNRRRLVIKDLPQDPKSQCAPVPGSRI 450

  Fly    67 RQLRNLSQPENSHKTSRSLCPDTAKTEPKVYSLRFVLNKSEDKDYMSRLKAQNDFSQSSCLCNNL 131
            .....|:..|...:.|||..|.|.|.
Zfish   451 NHPDGLTPAETERRPSRSSTPPTLKA--------------------------------------- 476

  Fly   132 SHANTEAGAYQNDGILKGQRDHSDFLTAAGGIQSRADRIARIETCGIRTTHLQPETQILKPVTEP 196
                        |.:|     |:..:...|| |.|:|| |.:|..|        :.|:....|..
Zfish   477 ------------DALL-----HAGIVCLTGG-QDRSDR-AVLEVYG--------DHQVWISATLS 514

  Fly   197 NETRFDQHSPDWLFKNSRIGDVSNSSKLSACNSELPPEEYKGRTLYHD------------TKFDC 249
            ::..|.............:.||..:....|......||..|.....|:            ...|.
Zfish   515 SQEIFKLLLYFHTITRKGMKDVGMTVVFDARKKPPHPEFTKALLTLHEKDPGAVHCVVLLLNKDS 579

  Fly   250 AYIKNRRPLITTESKMS------------ITEAEHPQTKYTD---IKYDYKTCSISQGLHQNKAF 299
            :|...:||.:|.|:..|            :|.|.|....|:.   |:...|.......|....|.
Zfish   580 SYSHEKRPGVTVETVTSYKALYKLVEVSQLTAALHGSLLYSHWDWIQIHQKLYPFVSDLQDASAL 644

  Fly   300 LNKVPPSKQSKPFHSVD----------------YDYYENIQKLHLSK------------------ 330
            |:..  .|:.:..|.:|                .:..|:.:.:.|.:
Zfish   645 LSGA--IKKLEGVHKIDTVQDVQQCIKEQAALMKNVLEDARLVELQRGGGAMLARLRRETDVRSP 707

  Fly   331 --ESERQIRD------NGDPNDLQNFLKKNLIKA------------------------TTNELLK 363
              |..|::.|      ||....:....:|:.:..                        |..|...
Zfish   708 HCEQSREVIDTVTHLYNGMEEQVHVLARKSNMSLQHLDFLLQLRHMEARFAQIKEWFDTEGETQL 772

  Fly   364 AAAQSTKKCNIDLERKLNDL-----NIKEEDHTS----NDS----GNSYKNDPY---LVSMSKIN 412
            ..|:|..:.:..:::.|...     ...|..|.:    :|:    |.:|.....   :|||.|.:
Zfish   773 LQAESVDESSEQIQQTLQTFKAFLSEANERKHQAMMLVSDAERIQGPNYPETEVFHRMVSMFKSS 837

  Fly   413 SCKFIRSYNRDCETIFPTGDHSDLNEFRKSFMPQSVDLLSSASVSLSSCDGSCLNKDSICGSEED 477
            ...|:....|.||.:              :.|.....:...||.....| ..||.::|:|...::
Zfish   838 VSDFVSRAERCCEEL--------------AMMVYICHICERASAVAGDC-RLCLEQESLCCPADE 887

  Fly   478 ----------------------------CC---------------ECNEY--------------- 484
                                        |.               :|.|.
Zfish   888 QHWARLHAHLQRLDEFPPELLQDVRTQACALSSSRALRVWDAAWVKCEEVRRMLEERLMLLEGDQ 952

  Fly   485 ------------QCIATPPNELSKDCLNAVEEGVFCNTEYDDFHENLT----------------- 520
                        ||.||...:..::|:  .|.....|...|..|..:|
Zfish   953 THHGHHTDWTTGQCDATALEDEERECV--PESETRANRSRDSIHNTVTCFNFRSKPRRDSKNTAT 1015

  Fly   521 -----SSC----------------CCSGSFCDDDGCSYLDEGLSVDIKSKNVQSLHESGTDEKLS 564
                 :.|                ..||:   ..||.:.....:|:..|.....||   ..|.:.
Zfish  1016 TRETPADCSQRGRSSSRRAAPEQRAVSGA---PVGCQWFPWQNTVNRSSSRRSELH---ITEPIQ 1074

  Fly   565 RKTILLARTEDTN-DVTQGISDGTTYFTGSLNITHLPKSNEIFKKPQDPEMQRHRRGHILKELFE 628
            |.....::|.||: |..:...:.|.       .||...|..:       ::||     |::||..
Zfish  1075 RHNSFSSQTHDTHGDAWRNEGENTA-------DTHESPSRSM-------KLQR-----IMEELLL 1120

  Fly   629 TEKIYVNEIASILKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTER 693
            ||..||..:..||..||. |.|....|..|:|:...:||||.::|.||...|.::|:.|.:...|
Zfish  1121 TEVEYVRSLGYILTHYYP-LLSRPDVPQDLRGQRGRIFGNLEKLYDFHCQHFQQELQACQAEPLR 1184

  Fly   694 VALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQRIT 758
            ...||:..|:.| .||:.|.:|..:|    :.|:..|.:||..|:.||..:.|.:|||||||||:
Zfish  1185 AGRCFLNHRESF-GLYALYSKNKPQS----DALIQHHRYFKRKQLELGDSMDLSSYLLKPVQRIS 1244

  Fly   759 KYQLLLKDLLLFTDNDSC-------RNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGEL 816
            ||.|||:::|     |.|       |.|::.||:.:...|:..||.:...:|.....:|.:||:|
Zfish  1245 KYSLLLQEIL-----DECVSDQSPEREEIQAALEVVRFQLRHGNDLLTMDAIRDCDLNLNEQGQL 1304

  Fly   817 LMQDSFQVWIESKKDIRLRMKPKRRHIFLYQKSLLLCKQTSKSGYNKSSYQFKSDVKMSQIGLTE 881
            :.||.|.|....|:.:        |.:||:|..:|..| |.|:......|.:|..:|..:||:|:
Zfish  1305 IRQDEFWVIFRKKRSL--------RRVFLFQDVILFTK-TKKNDRGDDVYVYKLSIKTCEIGMTQ 1360

  Fly   882 SVSGDAKRFEVWLKGR--QEVYTLQASTIGVKEMWVAEIKRVLFNQLEKLKGDQIARYNIRHQSL 944
            |.....:.||:|.:.|  |:.|.|||.|..:|..|..:::.:|:.|  .||..::.    |.:.|
Zfish  1361 SCGLSGRSFEIWFRRRRSQDTYILQAETRDIKHAWTTDLEHILWEQ--ALKSRELR----RQERL 1419

  Fly   945 WQKSSC------------------------------EAPNITHCSLRRTECFELPLND---SNRN 976
            :..:.|                              :.||.....|:|...  ||..|   |...
Zfish  1420 FMGTGCKPFVDIQPRNAAVNHTVNGDVTGRELVGILKTPNPLVSGLQRGGA--LPRPDSIGSGST 1482

  Fly   977 TNIRSEKTCLSDQNIVNGPSV-QDQHE---KNSWSSDCSDIDEDETINPILMQKTGQPK-----L 1032
            |:....::..|.......||| |.::|   :|:..:.|:    |.|.:      ||:.:     |
Zfish  1483 TSTAGSQSSSSSGRGSMSPSVFQGKYESLVENAGLTGCA----DHTCS------TGRRRSSVSSL 1537

  Fly  1033 LWNRSS---SHQVFIKSKYILSRKTVN 1056
            |.:|||   :|.:...|. .||||.::
Zfish  1538 LHSRSSASPAHSIHYSSP-ALSRKMLS 1563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	66/180 (37%)
		PH-like	802..925	CDD:302622	38/124 (31%)
		PH	829..922	CDD:278594	28/94 (30%)
si:dkey-65j6.2	XP_009295405.2	SPEC	634..>803	CDD:321951	20/170 (12%)
		RhoGEF	1114..1283	CDD:306973	66/179 (37%)
		PH_puratrophin-1	1276..1411	CDD:270062	44/145 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910