DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stw and HEPH

DIOPT Version :9

Sequence 1:	NP_001137606.1	Gene:	stw / 35494	FlyBaseID:	FBgn0286203	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_620074.3	Gene:	HEPH / 9843	HGNCID:	4866	Length:	1212	Species:	Homo sapiens

Alignment Length:	640	Identity:	117/640 - (18%)
Similarity:	187/640 - (29%)	Gaps:	255/640 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 VLADGVERGILTANRM--IPG------PSIQVCENDKVVIDVENHMEGMEVTIHWHGIWQRGSQY 283
            :|::.:| |...:|||  |.|      |.:.:|:.|               |:.||.:.......
Human   660 LLSEDIE-GFQDSNRMHAINGFLFSNLPRLDMCKGD---------------TVAWHLLGLGTETD 708

  Fly   284 YDGVPFVTQCPIQQGNTFRYQWTGNAGTHFWHAHTGLQKLDGLYGSVVVRQPPSRDPNSHLYDFD 348
            ..||.|       ||||.:.|.. ..|......||.:         :.:.||      .:|..|:
Human   709 VHGVMF-------QGNTVQLQGM-RKGAAMLFPHTFV---------MAIMQP------DNLGTFE 750

  Fly   349 LTTHIMLISDWLHEDAAERYPGRLAV-NTGQDPESMLINGKGQFRDPNTGFMTNTPLEIFTITPG 412
            :..          :..:.|..|..|: |..|.|...                         .||.
Human   751 IYC----------QAGSHREAGMRAIYNVSQCPGHQ-------------------------ATPR 780

  Fly   413 RRYRFRMINAFAS------VCP---------AQVTIEGHGMTVIAT-DGEPVHPVDVNTIISFSG 461
            :||:...|....:      .||         .|...:.:|...::. ||             ..|
Human   781 QRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDG-------------LLG 832

  Fly   462 ERYDFVISADQPVGAYWIQLRGLGECGIRRAQQLAIL-----------------RYARGPYQ--- 506
            .||...:..:...|.:.|.....|.     .:.|.||                 ..|..||.
Human   833 SRYKKAVFREYTDGTFRIPRPRTGP-----EEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHA 892

  Fly   507 ----------PASSPP----TYDVGIPQGVILNPLDAICDR----KRAD-------------AVC 540
                      |.::.|    ||...||:.....|.|:.|..    ...|             |:|
Human   893 HGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAIC 957

  Fly   541 VSNLKNAKKVDKGVL--------VERPDVKIFLPFRFFVYEPKALFIPNTYNRFLVVPSGDHLTS 597
                      .||:|        ::|....:||.|.    |.|:.:
Human   958 ----------QKGILEPHGGRSDMDREFALLFLIFD----ENKSWY------------------- 989

  Fly   598 LVDEISYISPPAPPLSQIDDIPPEYFCNGDNRPPNCGPNCECTHMVDIPLGAIVEVVLVDEVQQV 662
            |.:.::......|....:.|   |.|...:.           .|.::..|.|.:..:.:.:.::|
Human   990 LEENVATHGSQDPGSINLQD---ETFLESNK-----------MHAINGKLYANLRGLTMYQGERV 1040

  Fly   663 NLSHPFHLHGTAFYVVGLGRSPDKSIKKINLKHALELDQMGMLERHFSKPPLKDTIAVPNNGYVV 727
                       |:|::.:|:..|        .|.:.......|.|: .:....|.:.:....:.|
Human  1041 -----------AWYMLAMGQDVD--------LHTIHFHAESFLYRN-GENYRADVVDLFPGTFEV 1085

  Fly   728 IRFRADNPGYWLFHCHFLFHIVIGMNLIFHI-GTTADLPP-----------VPPR 770
            :...|.|||.||.|||...|:..||..:|.: ..|..|.|           ||||
Human  1086 VEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITKETEKAVPPR 1140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stw	NP_001137606.1	ascorbase	230..756	CDD:274555	108/609 (18%)
		CuRO_1_tcLCC2_insect_like	230..333	CDD:259927	24/110 (22%)
		CuRO_2_tcLCC_insect_like	352..500	CDD:259951	26/181 (14%)
		CuRO_3_tcLLC2_insect_like	599..767	CDD:259972	33/179 (18%)
HEPH	NP_620074.3	CuRO_1_ceruloplasmin	80..262	CDD:259884
		CuRO_2_ceruloplasmin	277..417	CDD:259907
		CuRO_3_ceruloplasmin	431..626	CDD:259886
		CuRO_4_ceruloplasmin	629..772	CDD:259908	33/160 (21%)
		CuRO_5_ceruloplasmin	787..959	CDD:259887	31/199 (16%)
		Cupredoxin	974..1117	CDD:302766	36/199 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12110
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R446
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.140