DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stw and LAC3

DIOPT Version :9

Sequence 1:	NP_001137606.1	Gene:	stw / 35494	FlyBaseID:	FBgn0286203	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_180580.1	Gene:	LAC3 / 817571	AraportID:	AT2G30210	Length:	570	Species:	Arabidopsis thaliana

Alignment Length:	630	Identity:	155/630 - (24%)
Similarity:	242/630 - (38%)	Gaps:	129/630 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 LEYYTVLGAACQ-----VCTPNATNTVWSHCQCVLADGVERGILTANRMIPGPSIQVCENDKVVI 258
            |.|:..|.:|..     |.||.....:....|.:          |.|...|||::.|...|.:.|
plant    16 LAYFAFLASAEHHVHQFVITPTPVKRLCRTHQSI----------TVNGQYPGPTLVVRNGDSLAI 70

  Fly   259 DVENHMEGMEVTIHWHGIWQRGSQYYDGVPFVTQCPIQQGNTFRYQW--TGNAGTHFWHAHTGLQ 321
            .|.|... ..::||||||.|..:.:.||..::|||||:.|.|:.|::  ....||.:||||:...
plant    71 TVINRAR-YNISIHWHGIRQLRNPWADGPEYITQCPIRPGQTYTYRFKIEDQEGTLWWHAHSRWL 134

  Fly   322 KLDGLYGSVVVRQPPSRDPNSHLYDFDLTTH--IMLISDWLHEDAAE-----RYPGRLAVNTGQD 379
            :.. :||:::: .|....|    |.|.:...  .:|:.:|...:..:     ::.| .|.|..
plant   135 RAT-VYGALII-YPRLGSP----YPFSMPKRDIPILLGEWWDRNPMDVLKQAQFTG-AAANVS-- 190

  Fly   380 PESMLINGK--GQFRDPNTGFMTNTPLEIFTITPGRRYRFRMINA------FASVCPAQVTIEGH 436
             ::..|||:  ..:|....|.:.      |.|.||...:.|:|||      |.||.       .|
plant   191 -DAYTINGQPGDLYRCSRAGTIR------FPIFPGETVQLRVINAGMNQELFFSVA-------NH 241

  Fly   437 GMTVIATDGEPVHPVDVNTIISFSGERYDFVISADQPVGAYWIQLRGLGECG--IRRAQQLAILR 499
            ..||:.||.....|...|.|:...|:..:.:::|:|..|.|::..|......  .......|||:
plant   242 QFTVVETDSAYTKPFTTNVIMIGPGQTTNVLLTANQRPGRYYMAARAYNSANAPFDNTTTTAILQ 306

  Fly   500 YARGPYQPASS----PPTYDVGIPQGVILNPLDAICDRKRADAVCVSNLKNAKK------VDKGV 554
            |...|.:....    .|.:.|          |....|...|.|. .:.|:..|:      ||:.:
plant   307 YVNAPTRRGRGRGQIAPVFPV----------LPGFNDTATATAF-TNRLRYWKRAPVPQQVDENL 360

  Fly   555 LVERPDVKIFLPFRFFVYEPKALFIPNTYNRFLVVPSGDHLTSLVDEISYISPPAPPLSQ----- 614
                          ||......:...|..:.....|:|....:.::.:|::.|.:..:.|
plant   361 --------------FFTVGLGLINCANPNSPRCQGPNGTRFAASMNNMSFVLPRSNSVMQAYYQG 411

  Fly   615 --------IDDIPPEYFCNGDNRPPNCGPNCECTHMVDIPLGAIVEVVLVDEVQQVNLSHPFHLH 671
                    ...:||..|....|.........:.|....:...:.|::||.|.......:||.|||
plant   412 TPGIFTTDFPPVPPVQFDYTGNVSRGLWQPIKGTKAYKLKYKSNVQIVLQDTSIVTPENHPMHLH 476

  Fly   672 GTAFYVVGLG---RSPDKSIKKINLKHALELDQMGMLERHFSKPPLKDTIAVPNNGYVVIRFRAD 733
            |..|||||.|   .:|.....:.||                ..||.::||..|..|:|.|||.||
plant   477 GYQFYVVGSGFGNFNPRTDPARFNL----------------FDPPERNTIGTPPGGWVAIRFVAD 525

  Fly   734 NPGYWLFHCHFLFHIVIGMNLIFHI----GTTADLPPVPPRFPTC 774
            |||.|..|||...|:..|:.::|.:    |....:...|...|.|
plant   526 NPGAWFMHCHIDSHLGWGLAMVFLVENGRGQLQSVQAPPLDLPRC 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stw	NP_001137606.1	ascorbase	230..756	CDD:274555	142/570 (25%)
		CuRO_1_tcLCC2_insect_like	230..333	CDD:259927	35/104 (34%)
		CuRO_2_tcLCC_insect_like	352..500	CDD:259951	38/164 (23%)
		CuRO_3_tcLLC2_insect_like	599..767	CDD:259972	50/187 (27%)
LAC3	NP_180580.1	laccase	25..570	CDD:274556	151/619 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	85	1.000	Domainoid score	I2814
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	1	1.000	-	-		FOG0000424
OrthoInspector	1	1.000	-	-		mtm1062
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X253
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.880