DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stw and Hephl1

DIOPT Version :9

Sequence 1:	NP_001137606.1	Gene:	stw / 35494	FlyBaseID:	FBgn0286203	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001178922.2	Gene:	Hephl1 / 500946	RGDID:	1564835	Length:	1159	Species:	Rattus norvegicus

Alignment Length:	904	Identity:	174/904 - (19%)
Similarity:	274/904 - (30%)	Gaps:	331/904 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VANSQQN--QPKKENQP------------DLTPMGSFWQQHVATPSSSTPFDSPFFSATHGLVQT 83
            |.|.:.|  .||...|.            |.:|.|  :.:....|.:::..||..:     ..|.
  Rat   362 VGNCRGNAPHPKMRGQQRRYFIAAEKVLWDYSPQG--YDKFTGFPLNTSGSDSAVY-----FTQA 419

  Fly    84 HPSIGGSH-------SGPAPLNGNSLGSGAPSSI-LAGTKPALTAGSG------YLNSRGS---- 130
            ...|||.:       ...|..:...:.|.:.:.: :.|  |.:.|..|      :.|....
  Rat   420 DNRIGGKYWKARYTEYVDATFSRRKMPSDSEAHLGILG--PVIKAEVGDILLVTFANKADKVYSI 482

  Fly   131 LPTSARYPANKITGTVVEPNPKSPFRHLDFSTSATAELRRNPALSAPDECARACREGEPPRICYY 195
            ||....|......|..|:...| |..|:....:.|.......::|..|:        :||.:.|.
  Rat   483 LPHGVFYDKASDAGPNVDGFLK-PGAHVKPGETFTYRWTVPESVSPTDD--------DPPCLTYL 538

  Fly   196 HFTL-----EYYTVLGAACQVCTPNATNTVWSHCQCVLADGVERGI------------------- 236
            :|:.     :....|.....||.....|          |||.::||
  Rat   539 YFSAVQPIKDTSAGLVGPLLVCKKGTLN----------ADGTQKGIDKEFYLLFTVFDENFSSYL 593

  Fly   237 ---------------------LTANRM--IPG------PSIQVCENDKVVIDVENHMEGMEVTIH 272
                                 :.:|||  |.|      |.:.:|:.|:    |..|:.||.....
  Rat   594 DENIQKFTWHPFSVDKEDKEFVKSNRMHAINGYMYGNQPGLSMCKKDR----VSWHLIGMGTDTD 654

  Fly   273 WHGIWQRGSQYYDGVPFVTQCPIQQGNTFRYQWTGNAGTH------FWHA---------HTGLQK 322
            .||:      |:            ||||...:     |||      |.|.         |:|:.|
  Rat   655 MHGV------YF------------QGNTIHLR-----GTHRDSLALFPHMSTTAFMQPDHSGIFK 696

  Fly   323 L---------DGLYGSVVVRQPPSRDPNSHLYDFDLTTHIMLISDWLHEDAAERYPGRLAVNTGQ 378
            :         .|:.....|....:|||:...|....|.:|          |||......|.|...
  Rat   697 VFCSTLHHFTRGMGQIYEVSSCGNRDPSEPPYGMLRTFYI----------AAEEVEWDYAPNKNW 751

  Fly   379 DPESMLINGKGQFRDPNTGFMTNTPLEIFTITPGRRYRFRMINAFAS-------VCPAQVTIEGH 436
            :.|...::..|: |..:. ||.:|...|     |.:||..:...:.:       ..|.|   |.|
  Rat   752 EFEKQHLDAGGE-RHGDI-FMNHTENWI-----GSQYRKVVYREYTNGEFVEIKARPPQ---EEH 806

  Fly   437 ----GMTVIATDGEPVHPVDVNTIISFSGERYDFVISADQPVGAYWIQLRGLGECG--------I 489
                |..:.|..|:.:       :|.|..:       |.:|   |.|..:|:.:..        :
  Rat   807 LQLLGPMIHAEVGDSI-------LIIFKNK-------ASRP---YSITAQGVEDSDSGKFLDVPV 854

  Fly   490 RRAQQLAILRY------ARGPYQPASSPPTY-----DVGIPQGVILNPLDAICDRKRADAVCVSN 543
            .:..::...|:      ..||..|...|..|     .|......::.||          ..|...
  Rat   855 TKPGEIKTYRWNVPKRSGPGPSDPNCIPWVYFSTANFVKDTYSGLMGPL----------ITCREG 909

  Fly   544 LKNAKKVDKGVLVERPDVKIFLPFRFFVYEPKALFIPNTYNRFLVVPSGDHLTSLVDEISYISPP 608
            :.|    :||   .|.||.         ||...||:  .:|.              :|..|
  Rat   910 VLN----EKG---RRSDVD---------YEFALLFL--VFNE--------------NESWY---- 938

  Fly   609 APPLSQIDDIPPEYFCNGDNRPPNCGPNCECTHMVDIPLGAIVEVVLVDEVQQVNLSHPF----- 668
                  :||...:|.    |:.|.     :..|              .|:.::.|..|..
  Rat   939 ------LDDNIKKYL----NKDPR-----DFRH--------------TDDFEESNRMHAINGKIF 974

  Fly   669 -HLHG--------TAFYVVGLGRSPDKSIKKINLKHALELDQMGMLERHFSKPPLKDTIAVPNNG 724
             :|.|        |.:|::|:|...|        .|.:.......|.: ..|...:|...:....
  Rat   975 GNLPGLIMTEDSMTNWYLLGIGSEVD--------IHTIHYHAESFLFK-IDKSYREDVYDLFPGT 1030

  Fly   725 YVVIRFRADNPGYWLFHCHFLFHIVIGMNLIFHIGTTAD-LPPVPPRFPT-CGDHVPPV 781
            :..|...||:||.||.|||...||..||...:.:....| ..|...:.|: .|.|...|
  Rat  1031 FQTIELFADHPGTWLLHCHVSDHIHAGMETTYTVLRNIDNRIPYSTKSPSGAGPHAVTV 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stw	NP_001137606.1	ascorbase	230..756	CDD:274555	125/641 (20%)
		CuRO_1_tcLCC2_insect_like	230..333	CDD:259927	32/174 (18%)
		CuRO_2_tcLCC_insect_like	352..500	CDD:259951	30/166 (18%)
		CuRO_3_tcLLC2_insect_like	599..767	CDD:259972	37/182 (20%)
Hephl1	NP_001178922.2	CuRO_1_ceruloplasmin	26..208	CDD:259884
		CuRO_2_ceruloplasmin	222..362	CDD:259907	174/904 (19%)
		CuRO_3_ceruloplasmin	376..572	CDD:259886	40/223 (18%)
		CuRO_4_ceruloplasmin	575..718	CDD:259908	29/169 (17%)
		Cupredoxin	732..907	CDD:418529	40/221 (18%)
		Cupredoxin	923..1065	CDD:418529	40/199 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110