DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stw and Mco3

DIOPT Version :9

Sequence 1:	NP_001137606.1	Gene:	stw / 35494	FlyBaseID:	FBgn0286203	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_651441.1	Gene:	Mco3 / 43134	FlyBaseID:	FBgn0039387	Length:	677	Species:	Drosophila melanogaster

Alignment Length:	681	Identity:	216/681 - (31%)
Similarity:	329/681 - (48%)	Gaps:	124/681 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 PKSPFRHLDFSTSATAELRRNPALSAPDE----------------CARACREGEPPRICYYHFTL 199
            |::.|....|:.......:..|||...::                |.|.|::|:... |||...:
  Fly    57 PQAKFEWPSFAWMRNKTTKGTPALDLKNDYSQMELANFGDFDRHPCRRVCQQGQSQN-CYYQLVV 120

  Fly   200 EYYTVLGAACQVCTPNATNTVWSHCQCVLADGVERGILTANRMIPGPSIQVCENDKVVIDVENHM 264
            ..|..||..||.|..:.......|  |:..|||...::..|||:|||||::||||.||:||.|::
  Fly   121 HNYQRLGPECQRCQFDERACASEH--CIYGDGVANPVMAVNRMVPGPSIELCENDTVVVDVLNYL 183

  Fly   265 EGMEVTIHWHGIWQRGSQYYDGVPFVTQCPIQQGNTFRYQW-TGNAGTHFWHAHTGLQKLDGLYG 328
             ....|:||||:....:...||.||:||.|:|.|...|::: ...:|:.::|:|.|.|:..|:.|
  Fly   184 -SEPTTMHWHGVHMHRTPEMDGAPFITQYPLQPGEVQRHEFKVDRSGSLWYHSHVGWQRGFGVAG 247

  Fly   329 SVVVRQPPSRDPNSHLYDFDLTTHIMLISDWLHEDAAERYPGRLAVNTGQDPESMLINGKGQFRD 393
            :.||||....:.:|.|||:||..|.::|.|..:|           .|. ||..::|:||||:
  Fly   248 AFVVRQTSQENQHSQLYDYDLVEHTLMIQDIFYE-----------YNL-QDVRNILVNGKGR--- 297

  Fly   394 PNTGFMTNTP-------LEIFTITPGRRYRFRMI-NAFASVCPAQVTIEGHGMTVIATDGEPVHP 450
               ..::..|       .|...:|||.|||.|:| |..|: ||.:.:||.|.:.:|:|||..:.|
  Fly   298 ---NHLSQLPDNDNRHRYERLRVTPGYRYRMRVILNGIAN-CPVEFSIEQHRLLMISTDGNDIEP 358

  Fly   451 VDVNTIISFSGERYDFVISADQPVGAYWIQLRGLGECGIRRAQQLAILRYARGPYQPASSPPTYD 515
            |..:.....|.||:|||:.|:|....|||:::|..:|..|...|.|:|.| ||..:..
  Fly   359 VLADGFFLTSAERFDFVLEANQYKKNYWIRIKGYEQCENRNIYQGAVLSY-RGSARSE------- 415

  Fly   516 VGIPQGVILN-PLDAICDR----------KRADAVCVSNLKNAKKVDK--GVLVERPDVKIFLPF 567
              :|||.||: |.....|.          |.|::..:|:|:.:...|.  |.:..|.
  Fly   416 --LPQGDILDKPSSRAADEDLILVNDFRFKPANSTAISSLRQSLDKDNNVGTVALRS-------- 470

  Fly   568 RFFVYEPKALFIPNT-YNRFL---------VVPSGDHLTSLVDEISYISPPAPPLS----QIDDI 618
                .:|    :|.| |.:||         ..|:|:.|..:.| |||.||....|.    ..||
  Fly   471 ----VDP----VPWTRYTKFLTHYSSFGSRTAPNGEVLFQISD-ISYNSPGISLLQGRHLYQDD- 525

  Fly   619 PPEYFCN-----GDNRPPNCGPN-CECTHMVDIPLGAIVEVVLVDEVQQVNLSHPFHLHGTAFYV 677
              .||||     .:.|  ||... |||.:::.:|....:|:|:.:   .::.:||||:||..|.:
  Fly   526 --RYFCNKSSLAAEGR--NCERELCECVNVMRLPAYRPLEMVVAN---YLDSTHPFHIHGFTFRL 583

  Fly   678 VGLGRSPDKSIKKIN-LKHALELDQMGMLER--HFSKPPLKDTIAVPNNGYVVIRFRADNPGYWL 739
            ||.|     .:..:| |::..|||:.|.|.|  ..|....|||:.:|..||:::||.::|||:||
  Fly   584 VGQG-----VLGNLNDLRNIQELDRRGRLPRLSEDSAAVAKDTVQIPGQGYIIVRFISNNPGFWL 643

  Fly   740 FHCHFLFHIVIGMNLIFHIGTTADLPPVPPR 770
            :|||...|.|.||..:..||....:..:|.|
  Fly   644 YHCHVEAHAVQGMVAVLKIGEDHQMKNIPAR 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stw	NP_001137606.1	ascorbase	230..756	CDD:274555	191/570 (34%)
		CuRO_1_tcLCC2_insect_like	230..333	CDD:259927	43/103 (42%)
		CuRO_2_tcLCC_insect_like	352..500	CDD:259951	52/155 (34%)
		CuRO_3_tcLLC2_insect_like	599..767	CDD:259972	63/180 (35%)
Mco3	NP_651441.1	CuRO_1_tcLCC2_insect_like	149..252	CDD:259927	43/103 (42%)
		laccase	151..656	CDD:274556	187/564 (33%)
		CuRO_2_tcLCC_insect_like	270..408	CDD:259951	52/156 (33%)
		CuRO_3_tcLLC2_insect_like	502..671	CDD:259972	63/182 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	120	1.000	Domainoid score	I1881
eggNOG	1	0.900	-	-		E1_COG2132
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I2375
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58299
OrthoDB	1	1.010	-	-		D257925at33208
OrthoFinder	1	1.000	-	-		FOG0000424
OrthoInspector	1	1.000	-	-		mtm1062
orthoMCL	1	0.900	-	-		OOG6_100257
Panther	1	1.100	-	-	P	PTHR11709
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X253
	11	10.880