DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stw and fio1

DIOPT Version :9

Sequence 1:	NP_001137606.1	Gene:	stw / 35494	FlyBaseID:	FBgn0286203	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_594494.1	Gene:	fio1 / 2541558	PomBaseID:	SPAC1F7.08	Length:	622	Species:	Schizosaccharomyces pombe

Alignment Length:	567	Identity:	145/567 - (25%)
Similarity:	226/567 - (39%)	Gaps:	134/567 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 GVERGILTANRMIPGPSIQVCENDKVVIDVENHMEGMEVT-IHWHGIWQRGSQYYDGVPFVTQCP 294
            |..|.::..|...|...:.|...|:|:|.:.|.:.....| :|.||::|:.:.|.||||..|||.
pombe    43 GNSRWVIGVNNKWPIDPLVVDYGDQVIIKMTNSLANNRTTSLHSHGLFQKFTPYMDGVPQSTQCE 107

  Fly   295 IQQGNTFRYQWTG-NAGTHFWHAHTGLQKLDGLYGSVVVRQPPSRDPNSHLYDFDLTTHIMLISD 358
            |..|.||.|.:|. ..||::.|:|...|..|||....::.  ...:|    ||:| ..:|:.::|
pombe   108 IPPGATFYYNYTALQNGTYWVHSHDMSQYPDGLRTPFIIN--ALEEP----YDYD-EEYIISMTD 165

  Fly   359 WLHEDAAERYPGRLAV---NTGQDPESMLINGKGQFRDPNTGFMTNTPLEIFTITPGRRYRFRMI 420
            |.:.......|.....   .||.:|.            |:||...:|....|.:.||:.||.|.|
pombe   166 WYYTPFNILVPDEFKTWKNPTGAEPV------------PDTGLFNDTANATFAMEPGKTYRLRFI 218

  Fly   421 N--AFASVCPAQVTIEGHGMTVIATDGEPVHPVDVNTIISFSGERYDFVISA------DQPVGAY 477
            |  ||.:.   .|.||.|.||:|..|||...|.:|::|.....:||..:::|      :..:.||
pombe   219 NIGAFNNY---DVMIEDHNMTIIEVDGEYTEPQEVSSIHLTVAQRYSVLVTAKNSTDRNYAITAY 280

  Fly   478 WIQLRGLGECGIRRAQQLAILRYARGPYQP-------ASSPPTYDVGIPQGVILNPLDAICDRKR 535
            ..:               ::.......|.|       .:|..:||:| |.   ::.:|:..|
pombe   281 MDE---------------SLFDTIPDNYNPNVTAWLSYNSDASYDLG-PD---IDEIDSYDD--- 323

  Fly   536 ADAVCVSNLKNAKKVDKGVLVERPDVKIFLPFRFFVYEPKALFIPNTYNRFLVVPSGDHLTSLVD 600
                  :.|......|    |...:..|.:.|.||.....|.:                  :.::
pombe   324 ------AELNPLYSWD----VTESNHSINIWFDFFTLGDGANY------------------AEIN 360

  Fly   601 EISYISPPAPPLSQIDDIPPEYFCNGDN------RPPNCGPNCECTHMVDIPLGAIVEVVLVDEV 659
            :.||:.|..|.:         ...|..|      .|...||   .|:......|.:|:|::.:..
pombe   361 DSSYVFPKVPSI---------MIANSTNVDGYNLEPVTYGP---YTNAYIFEYGDVVDVIIDNHD 413

  Fly   660 QQVNLSHPFHLHGTAFYVVGLGRSPDKSIKKINLKHALELDQMGMLERH--FSKPPLKDTIAVPN 722
            ..   .|||||||..|.|:..|..          ...|..||    |.|  :..|..:||:.:..
pombe   414 TG---KHPFHLHGHTFQVLERGEE----------NAGLYSDQ----ESHTYYDNPMRRDTVEIEP 461

  Fly   723 NGYVVIRFRADNPGYWLFHCHFLFHIVIGMNLIFHIGTTADLPPVPP 769
            ..::||||.|||||.|:.|||..:|:..|:     :.|..:.|.:.|
pombe   462 GSFIVIRFIADNPGAWVIHCHIEWHMESGL-----LATFIEAPEMIP 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stw	NP_001137606.1	ascorbase	230..756	CDD:274555	142/552 (26%)
		CuRO_1_tcLCC2_insect_like	230..333	CDD:259927	36/103 (35%)
		CuRO_2_tcLCC_insect_like	352..500	CDD:259951	39/158 (25%)
		CuRO_3_tcLLC2_insect_like	599..767	CDD:259972	48/175 (27%)
fio1	NP_594494.1	SufI	5..500	CDD:225043	143/562 (25%)
		Cupredoxin	27..147	CDD:302766	36/103 (35%)
		CuRO_2_Fet3p_like	157..305	CDD:259945	41/177 (23%)
		CuRO_3_Fet3p	337..499	CDD:259966	52/213 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	84	1.000	Domainoid score	I2221
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I1110
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000424
OrthoInspector	1	1.000	-	-		otm47180
orthoMCL	1	0.900	-	-		OOG6_100257
Panther	1	1.100	-	-	O	PTHR11709
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R446
SonicParanoid	1	1.000	-	-		X253
TreeFam	1	0.960	-	-
	11	10.850