Protein Alignment stw and Hephl1

DIOPT Version :10

• Sequence 1: NP_610170.2
• Gene: stw / 35494
• FlyBaseID: FBgn0286203
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_001158269.1
• Gene: Hephl1 / 244698
• MGIID: 2685355
• Length: 1159
• Species: Mus musculus
• Alignment Length: 718
• Identity: 139/718 - (19%)
• Similarity: 221/718 - (30%)
• Gaps: 269/718 - (37%)

  Fly   173 ALSAPDECARACREGEPPRICYYHFTL-----EYYTVLGAACQVCTPNATNTVWSHCQCVLADGV 232
            ::|..||        :||.:.|.:|:.     :....|.....||.....|          |||.
Mouse   524 SVSPTDE--------DPPCLTYLYFSAVQPIKDTSAGLVGPLLVCKKGTLN----------ADGT 570

  Fly   233 ERGI----------------------------------------LTANRM--IPG------PSIQ 249
            ::||                                        :.:|||  :.|      |.:.
Mouse   571 QKGIDKEFYLLFTVFDENFSSYLDENIKKFTWHPFSVDKEDKEFVKSNRMHAVNGYMYGSQPGLS 635

  Fly   250 VCENDKVVIDVENHMEGMEVTIHWHGIWQRGSQYYDGVPFVTQCPIQQGNTFRYQWTGNAGTH-- 312
            :|:.|:    |..|:.||......||:      |:            ||||...:     |||
Mouse   636 MCKKDR----VSWHLIGMGTDTDMHGV------YF------------QGNTIHLR-----GTHRD 673

  Fly   313 ----FWHA---------HTGLQKL---------DGLYGSVVVRQPPSRDPNSHLYDFDLTTHIML 355
                |.|.         |:|:.|:         .|:.....:....:|||:...|....|..|
Mouse   674 SLALFPHMATTAYMQPDHSGIFKVFCSTLPHFTRGMGQIYEISSCGNRDPSEPPYGMLRTFFI-- 736

  Fly   356 ISDWLHEDAAERYPGRLAVNTGQDPESMLINGKGQFRDPNTGFMTNTPLEIFTITPGRRYRFRMI 420
                    |||......|.|...:.|...::..|: |..:. ||.:|...|     |.:||..:.
Mouse   737 --------AAEEVEWDYAPNKNWEFEKQHLDAGGE-RHGDI-FMNHTENWI-----GSQYRKVVY 786

  Fly   421 NAFAS-------VCPAQVTIEGH----GMTVIATDGEPVHPVDVNTIISFSGERYDFVISADQPV 474
            ..:.:       ..|.|   |.|    |..:.|..|:.:       :|.|..:       |.:|
Mouse   787 REYTNGEFVEIKARPPQ---EEHLQLLGPMIHAEVGDSI-------LIIFKNK-------ASRP- 833

  Fly   475 GAYWIQLRGLGECGIRRAQQLAILRYARGPYQPASSP---PTYDVGIPQGVVMNPLDAQCNRQRN 536
              |.|..:|:.:....:...:           |.:.|   .||...:|:.....|.|..|
Mouse   834 --YSIAAQGVEDSNNGKLLNV-----------PVTKPGEIKTYRWNVPKRSGPGPSDPNC----- 880

  Fly   537 DAICVSQLKNALEIDRGILAEKPDVKIFLPFRFFVYRAEDLFQPNTYNRFL-------------- 587
                                        :|   :||.:...|..:||:..:
Mouse   881 ----------------------------IP---WVYFSTANFVKDTYSGLMGPLITCREGVLNEK 914

  Fly   588 -VASDADHLISLIDEVSYISPPSPMLSQYNDIPQEYYCNGDNRP---VDCGENCQCTHKIDVPLN 648
             ..||.|:..:|:..|.     :...|.|.|...:.|.|.|.|.   .|..|.....|.|:..:.
Mouse   915 GRRSDVDYEFALLFLVF-----NENESWYLDDNIKKYLNKDPRDFKHTDDFEESNKMHAINGKIF 974

  Fly   649 AIVEVVLVDEVQQINISHPFHLHGTSFYVLGLGRSPDKQIQRMNLKHALELDQRGLLERQYLKPS 713
            ..:..:::.|...           |::|:||:|...|        .|.:.......|.:  :..|
Mouse   975 GNLPGLIMTEDSM-----------TNWYLLGIGSEVD--------IHTIHYHAESFLFK--IDKS 1018

  Fly   714 LKDTV--AVPNNGYAILRFRADNPGFWLFHCHFQYHIVIGMNLVFQI--GTPNDLPPVPPNFPRC 774
            .::.|  ..|.....|..| ||:||.||.|||...||..||...:.:  ...|.:|.........
Mouse  1019 YREDVYDLFPGTFQTIELF-ADHPGTWLLHCHVSDHIHAGMETTYTVLRNIDNRIPYSTKTPSGA 1082

  Fly   775 GNH 777
            |:|
Mouse  1083 GSH 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stw	NP_610170.2	ascorbase	230..775	CDD:274555	125/652 (19%)
Hephl1	NP_001158269.1	CuRO_1_ceruloplasmin	26..208	CDD:259884
		Cupredoxin	222..362	CDD:473140
		CuRO_3_ceruloplasmin	376..572	CDD:259886	14/65 (22%)
		CuRO_4_ceruloplasmin	575..718	CDD:259908	27/169 (16%)
		Cupredoxin	732..907	CDD:473140	45/258 (17%)
		Cupredoxin	923..1065	CDD:473140	40/168 (24%)