DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stw and Cp

DIOPT Version :9

Sequence 1:	NP_001137606.1	Gene:	stw / 35494	FlyBaseID:	FBgn0286203	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001257890.1	Gene:	Cp / 24268	RGDID:	2387	Length:	1084	Species:	Rattus norvegicus

Alignment Length:	849	Identity:	152/849 - (17%)
Similarity:	261/849 - (30%)	Gaps:	331/849 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DLTPMG--SFWQQHVATPSSSTPFDSPFFSATHGLVQTHPSIGGSHS------------------ 92
            |..|.|  :|..:::.:..|    ||..|     ..|....||||:.
  Rat   383 DYAPSGTDTFTGENLTSLGS----DSRVF-----FEQGATRIGGSYKKLVYREYTDDSFTNRKQR 438

  Fly    93 GPAPLNGNSLGSGAPSSILAGTKPALTAGSGYL-----NSRGSLPTSARYPANKIT----GTVVE 148
            ||...:...||            |.:.|..|.:     :::|..|.|.:....:.|    ||...
  Rat   439 GPDEEHLGILG------------PVIWAEVGDIIRVTFHNKGQFPLSIQPMGVRFTKENEGTYYG 491

  Fly   149 PNPKSPFR--HL----DFSTSATAELRRNPALSAPDECARACREGEPPRIC----YY---HFTLE 200
            |:.:|..:  |:    .|:...|......|..:.|              :|    ||   ..|.:
  Rat   492 PDGRSSKQASHVAPKETFTYEWTVPKEMGPTYADP--------------VCLSKMYYSGVDLTKD 542

  Fly   201 YYTVLGAACQVCTPNATNTVWSHCQCVLADGVERGI-----LTANRMIPGPSIQVCENDKVVI-- 258
            .:|.|....::|...:          :||||.::.:     |.|.......|:.:.:|.::..
  Rat   543 IFTGLIGPMKICKKGS----------LLADGRQKDVDKEFYLFATVFDENESLLLDDNIRMFTTA 597

  Fly   259 --DVENHMEGMEVTIHWHGIWQRGSQYYDGVPFVTQCPIQQGNTFRYQWTGNAGTHFWHAHTGLQ 321
              :|:...|..:.:...|.:   ....|..:|.:..|   .|.:.           .|:..:...
  Rat   598 PENVDKEDEDFQESNKMHSM---NGFMYGNLPGLNMC---LGESI-----------VWYLFSAGN 645

  Fly   322 KLD--GLY--GSVVVRQPPSRD-----PNSHL-----------YDFD-LTTHIMLISDWLHEDAA 365
            :.|  |:|  |:..:.:...||     |:..|           :|.: |||
  Rat   646 EADVHGIYFSGNTYLSKGERRDTANLFPHKSLTLLMTPDTEGSFDVECLTT-------------- 696

  Fly   366 ERYPGRLAVNTGQDPESMLINGKGQFRD------PNTGFMTNTPLEIFTITPGRRYRFRM----- 419
            :.|.|      |...:..:...||||.|      ..|.::....:| :..:|.|.:...:
  Rat   697 DHYTG------GMKQKYTVNQCKGQFEDVTLYQGERTYYIAAVEVE-WDYSPSRDWEMELHHLQE 754

  Fly   420 ---INAFASVCPAQVTIEGHGMTVIATDGEPVHPVDVNTIISFSGERYDFVISADQPVGAYWIQL 481
               .|||                   .|.|..          |.|.:|..|:..:.....:..|:
  Rat   755 QNVSNAF-------------------LDKEEF----------FIGSKYKKVVYREFTDSTFREQV 790

  Fly   482 RGLGECGIRRAQQ--LAIL-----------------RYARGPY---------QPASSPPTYDVGI 518
            :       |||::  |.||                 ..|..||         :.::..||    :
  Rat   791 K-------RRAEEEHLGILGPLIHADVGDKVKVVFKNMASRPYSIHAHGVKTKSSTVAPT----L 844

  Fly   519 PQGVILNPLDAICDRKRA---DAVCV-----SNLKNAKKVDKG-----VLVERPDVKIFLPFR-- 568
            | |.:...:..|.:|..|   |:.|:     |.:...|.:..|     ::..:..||:|.|.:
  Rat   845 P-GEVRTYIWQIPERSGAGTEDSPCIPWAYYSTVDRVKDLYSGLIGPLIVCRKSYVKVFNPKKKM 908

  Fly   569 -----FFVY-EPKALFIPNTYNRFLVVPSGDHLTSL-VDEISYISPPAPPLSQIDDIPPEYFCNG 626
                 |.|: |.::.::.:..|.:     .||...: .|...:|..     :::..|..:.|.|.
  Rat   909 EFSLLFLVFDENESWYLDDNINTY-----SDHPEKVNKDNEEFIES-----NKMHAINGKMFGNL 963

  Fly   627 DNRPPNCGPNCECTHMVDIPLGAIVEVVLVDEV--------QQVNLSHPFHLHGTAFYVVGLGRS 683
            .....:.|                      |||        .:::| |..|.||
  Rat   964 QGLTMHVG----------------------DEVNWYVMAMGNEIDL-HTVHFHG----------- 994

  Fly   684 PDKSIKKINLKHALELDQMGMLERHFSKPPLKDTIAVPNNGYVVIRFRADNPGYWLFHCHFLFHI 748
                       |:.:....|:   |.|     |...:....|..:......||.||.|||...||
  Rat   995 -----------HSFQYKHRGI---HSS-----DVFDLFPGTYQTLEMFPQTPGTWLLHCHVTDHI 1040

  Fly   749 VIGM 752
            ..||
  Rat  1041 HAGM 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stw	NP_001137606.1	ascorbase	230..756	CDD:274555	110/625 (18%)
		CuRO_1_tcLCC2_insect_like	230..333	CDD:259927	18/115 (16%)
		CuRO_2_tcLCC_insect_like	352..500	CDD:259951	28/180 (16%)
		CuRO_3_tcLLC2_insect_like	599..767	CDD:259972	31/162 (19%)
Cp	NP_001257890.1	Cupredoxin	22..201	CDD:302766
		CuRO_2_ceruloplasmin	213..353	CDD:259907
		Cupredoxin	369..566	CDD:302766	44/227 (19%)
		CuRO_4_ceruloplasmin	569..712	CDD:259908	27/179 (15%)
		CuRO_5_ceruloplasmin	726..896	CDD:259887	35/211 (17%)
		CuRO_6_ceruloplasmin	907..1051	CDD:259898	37/201 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010