Protein Alignment stw and F8

DIOPT Version :10

• Sequence 1: NP_610170.2
• Gene: stw / 35494
• FlyBaseID: FBgn0286203
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_000123.1
• Gene: F8 / 2157
• HGNCID: 3546
• Length: 2351
• Species: Homo sapiens
• Alignment Length: 815
• Identity: 158/815 - (19%)
• Similarity: 246/815 - (30%)
• Gaps: 332/815 - (40%)

  Fly   124 YLNS-RGSLPTSARYPANKITGTVVEPNPKSPFRHLDFSTSATAELRRNPALSAPDECARACREG 187
            |:.| .|.||..||:|            |:.| :...|:||...:
Human    35 YMQSDLGELPVDARFP------------PRVP-KSFPFNTSVVYK-------------------- 66

  Fly   188 EPPRICYYHFTLEYYTVLGAACQVCTPNATNTVWSHCQCVLADGVERGILTANRMIPGPSIQVCE 252
               :..:..||...:       .:..|...   |            .|:|       ||:||...
Human    67 ---KTLFVEFTDHLF-------NIAKPRPP---W------------MGLL-------GPTIQAEV 99

  Fly   253 NDKVVIDVENHMEGMEVTIHWHGI--WQ--RGSQYYDGVPFVTQCPIQQGNTFRYQWTGNAGTHF 313
            .|.|||.::| |....|::|..|:  |:  .|::|.|.   .:|...:....|    .|.:.|:.
Human   100 YDTVVITLKN-MASHPVSLHAVGVSYWKASEGAEYDDQ---TSQREKEDDKVF----PGGSHTYV 156

  Fly   314 WH--------------------AHTGLQK--LDGLYGSVVVRQPPS--RDPNSHLYDFDLTTHIM 354
            |.                    :|..|.|  ..||.|:::|.:..|  ::....|:.|     |:
Human   157 WQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGALLVCREGSLAKEKTQTLHKF-----IL 216

  Fly   355 LIS------DWLHE---------DAA----------------ERYPGRL----------AVNTGQ 378
            |.:      .|..|         |||                ...||.:          .:..|.
Human   217 LFAVFDEGKSWHSETKNSLMQDRDAASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGT 281

  Fly   379 DPESMLINGKGQFRDPNTGFMTN---TPLEIFTIT----------PGRRYRFRMIN--------A 422
            .||...|     |.:.:|..:.|   ..|||..||          .|:...|..|:        |
Human   282 TPEVHSI-----FLEGHTFLVRNHRQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEA 341

  Fly   423 FASV--CPAQVTIE---------------GHGMTVIATDGE------------PVHPVDVNTIIS 458
            :..|  ||.:..:.               ...|.|:..|.:            ..||......|:
Human   342 YVKVDSCPEEPQLRMKNNEEAEDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIA 406

  Fly   459 FSGERYDF---VISAD-------------QPVGAYWIQLRGLG--------------ECGIRRAQ 493
            ...|.:|:   |::.|             |.:|..:.::|.:.              |.||
Human   407 AEEEDWDYAPLVLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHESGI---- 467

  Fly   494 QLAILRYAR-GP-----YQPASSPPTYDVGIPQGVV-MNPLDAQCNRQRNDAICVSQLKNALEID 551
             |..|.|.. |.     ::..:|.| |:: .|.|:. :.||.::                  .:.
Human   468 -LGPLLYGEVGDTLLIIFKNQASRP-YNI-YPHGITDVRPLYSR------------------RLP 511

  Fly   552 RGI--LAEKPDVKIFLPFRFFVYR----AED---LFQPNTYNRF---LVASDADHLISLIDEVSY 604
            :|:  |.:.|    .||...|.|:    .||   ...|....|:   .|..:.|....||
Human   512 KGVKHLKDFP----ILPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLI----- 567

  Fly   605 ISPPSPMLSQYNDIPQE--YYCNGDNRPV------DCGENCQCTHKIDVPLNAIVEVVLVD-EVQ 660
                .|:|..|.:...:  .....|.|.|      |...:...|..|...|.....|.|.| |.|
Human   568 ----GPLLICYKESVDQRGNQIMSDKRNVILFSVFDENRSWYLTENIQRFLPNPAGVQLEDPEFQ 628

  Fly   661 QINISHPFH------------LHGTSF-YVLGLGRSPD---KQIQRMNLKHALELDQRGLLERQY 709
            ..||.|..:            ||..:: |:|.:|...|   ........||
Human   629 ASNIMHSINGYVFDSLQLSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKH-------------- 679

  Fly   710 LKPSLKDTVAV-PNNGYAILRFRADNPGFWLFHCH 743
             |...:||:.: |.:|..:. ...:|||.|:..||
Human   680 -KMVYEDTLTLFPFSGETVF-MSMENPGLWILGCH 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stw	NP_610170.2	ascorbase	230..775	CDD:274555	141/708 (20%)
F8	NP_000123.1	CuRO_1_FVIII_like	22..201	CDD:259994	48/238 (20%)
		CuRO_2_FVIII_like	211..345	CDD:259901	27/143 (19%)
		CuRO_3_FVIII_like	399..575	CDD:259889	39/213 (18%)
		CuRO_4_FVIII_like	588..730	CDD:259902	34/141 (24%)
		B	760..1667
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	906..928
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	941..961
		CuRO_5_FVIII_like	1714..1880	CDD:259890
		CuRO_6_FVIII_like	1892..2035	CDD:259904
		FA58C	2042..2187	CDD:238014
		FA58C	2195..2344	CDD:238014