DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stw and F5

DIOPT Version :9

Sequence 1:	NP_001137606.1	Gene:	stw / 35494	FlyBaseID:	FBgn0286203	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_000121.2	Gene:	F5 / 2153	HGNCID:	3542	Length:	2224	Species:	Homo sapiens

Alignment Length:	608	Identity:	116/608 - (19%)
Similarity:	188/608 - (30%)	Gaps:	221/608 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 LTAGSGYLNSRGSLPTSARYPANKITGTVVEPNPKSPFRHLDFSTSATAELRRNPALSAPDECAR 182
            |:.|:.||:.        .:||.|:...|      :|.|...:..|.:.:       |.|
Human   122 LSEGASYLDH--------TFPAEKMDDAV------APGREYTYEWSISED-------SGP----- 160

  Fly   183 ACREGEPP---RICYYHFTL--EYYTVLGAACQVC-----TPNATNTV----------------- 220
              ...:||   .|.|.|..|  ::.:.|.....:|     |...|...
Human   161 --THDDPPCLTHIYYSHENLIEDFNSGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKS 223

  Fly   221 WSHCQCVLADGVERGILTANRMIPG--PSIQVCENDKVVIDVENHMEGME-----VTIHWH---- 274
            ||....::        .|.|..:.|  |.|.||.:|    .:..|:.||.     .:||::
Human   224 WSQSSSLM--------YTVNGYVNGTMPDITVCAHD----HISWHLLGMSSGPELFSIHFNGQVL 276

  Fly   275 ---------------------------GIW----------QRGSQ-YYDGVPFVTQCPIQQGNTF 301
                                       |.|          |.|.| |.|    :..||.:..|..
Human   277 EQNHHKVSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYID----IKNCPKKTRNLK 337

  Fly   302 RYQWTGNAGTHF--WHAHTGLQKLDGLYGSVVVRQPPSRDPNSHLYDF--DLTTHIMLISDWLHE 362
            :.  |.....|.  |......:::...|..|:......:..:.||.:|  .:..|...:....:|
Human   338 KI--TREQRRHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQHLDNFSNQIGKHYKKVMYTQYE 400

  Fly   363 DAAERYPGRLAVNTGQDPESMLING---KGQFRDPNTGFMTNTPLEIFTITPGRRYRFRMINAFA 424
            |  |.:. :..||.....:.:|  |   :.|.||        |...:|.....|.|
Human   401 D--ESFT-KHTVNPNMKEDGIL--GPIIRAQVRD--------TLKIVFKNMASRPY--------- 443

  Fly   425 SVCPAQVTIEGHGMTVIATDGEPVHPVDVNTIISFSGERYDFVISADQPVGAY---WIQLRGLGE 486
            |:.|       ||:|....:.|      ||:  ||:..|.:.:|.|.||...|   |
Human   444 SIYP-------HGVTFSPYEDE------VNS--SFTSGRNNTMIRAVQPGETYTYKW-------- 485

  Fly   487 CGIRRAQQLAILRY---ARGPYQPASSPPTYDVGIPQGVILNPLDAICDRKRADAVCVSNLKNAK 548
                     .||.:   .....|..:.|...||.|.:.:....:..:       .:|.|...:.:
Human   486 ---------NILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIGLL-------LICKSRSLDRR 534

  Fly   549 KVDKGVLVERPDVKIFLPFRFFVY-EPKALFIPNTYNRFLVVPSGDHLTSLVDEISYISP---PA 609
            .:.:...:|:..|       |.|: |.|:.::.:..|:|...|         ||:....|   .:
Human   535 GIQRAADIEQQAV-------FAVFDENKSWYLEDNINKFCENP---------DEVKRDDPKFYES 583

  Fly   610 PPLSQIDDIPPEY-----FCNGD 627
            ..:|.|:...||.     ||..|
Human   584 NIMSTINGYVPESITTLGFCFDD 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stw	NP_001137606.1	ascorbase	230..756	CDD:274555	91/469 (19%)
		CuRO_1_tcLCC2_insect_like	230..333	CDD:259927	28/153 (18%)
		CuRO_2_tcLCC_insect_like	352..500	CDD:259951	34/153 (22%)
		CuRO_3_tcLLC2_insect_like	599..767	CDD:259972	10/37 (27%)
F5	NP_000121.2	Cupredoxin	32..196	CDD:302766	21/101 (21%)
		Cupredoxin	208..326	CDD:302766	22/133 (17%)
		CuRO_3_FV_like	348..528	CDD:259992	46/240 (19%)
		CuRO_4_FV_like	541..684	CDD:259996	19/82 (23%)
		B	692..1573
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..842
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..927
		2 X 17 AA tandem repeats	895..928
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	982..1001
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1029..1048
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1097..1157
		35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T	1185..1501
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1341..1367
		CuRO_5_FV_like	1579..1754	CDD:259993
		Cupredoxin	1766..1902	CDD:302766
		FA58C	1906..2061	CDD:214572
		FA58C	1909..2060	CDD:238014
		FA58C	2065..2221	CDD:214572
		FA58C	2068..2220	CDD:238014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12110
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010