DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stw and F21D5.3

DIOPT Version :9

Sequence 1:	NP_001137606.1	Gene:	stw / 35494	FlyBaseID:	FBgn0286203	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001255321.1	Gene:	F21D5.3 / 177680	WormBaseID:	WBGene00009008	Length:	743	Species:	Caenorhabditis elegans

Alignment Length:	771	Identity:	185/771 - (23%)
Similarity:	289/771 - (37%)	Gaps:	224/771 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 VVEPNPKSPFRH-LDFSTSATAELRR-NPALSAP----DECARACREGEPPRI--CYYHFTLEYY 202
            :::|:....:.: :..|...|...:. |||..|.    |...:...:.||.::  |:.:::..:.
Worm    30 IMKPDSNGVYAYDMKISKKLTMAYKNDNPAKHATPVDYDYKTQTWSKREPNQLMDCFQNYSFNHI 94

  Fly   203 TVLGAACQVCTPNATNTVWSHCQCVLADGVERGILTANRMIPGPSIQVCENDKVVIDVENHMEGM 267
            :..|.|      |....|      ::.||:.:.:::.|..:||..:.|....:|.|.|.|.:...
Worm    95 SDPGDA------NRMEDV------LVVDGLHKRVISINGDMPGAPVVVPYMSEVWIRVSNQILMD 147

  Fly   268 EVTIHWHGIWQRGSQYYDGVPFVTQCPIQQGNTFRYQW-TGNAGTHFWHAHTGLQKLDGLYGSVV 331
            .:|||.|||.:.|..|.|||.||.|||||..|.|.|:: ..|.|||::|.|....:.||:.|..:
Worm   148 SMTIHVHGIDKHGMWYMDGVAFVQQCPIQSTNKFEYRFIADNKGTHWYHGHMQTDRGDGIAGGFI 212

  Fly   332 V---------------RQPPSRDPNSHLYDFDLTTHIMLISDWLHEDAAERY------------- 368
            |               |..|||:            :..|:.||..:...|.:
Worm   213 VVDQNDTSVPTLDDRKRIVPSRE------------YFFLLQDWATKVGEEAWMQLEDKTMKWMYG 265

  Fly   369 ---------PGRLA----VNTGQDPESMLINGKGQF-RDPNTGFMTNTPLEIFTITPGRRYRFRM 419
                     |.|.:    |.......::|:|.||.: .|.......|.|||.|.|.|.....||:
Worm   266 YDDFTKCWEPTRTSDGGNVGGAVPISAILLNDKGWYDHDIIKSQPFNLPLERFQIKPNEDILFRI 330

  Fly   420 INAFASVCPAQVTIEGHGMTVIATDGEPVHPVDVNTIISFSGERYDFVIS--ADQPVGAYWIQLR 482
            :|...:. ...:.:|||.|||:|.||:.|.|:.|:.:|.|.|||||.:|.  |.....:|.||:.
Worm   331 VNGGVAQ-ELMLYVEGHPMTVVAADGDEVVPMKVDRLIVFPGERYDILIKGLATPTKKSYRIQVE 394

  Fly   483 ----------------GLG---------------------ECGIRRAQQLAILRYARGPYQPASS 510
                            |.|                     ||  .:.::..:|..   |:|...:
Worm   395 TVQKYFFDWKEIPIVYGFGYIEYETDGLPEDKTTPNLMHPEC--TQNKKCTVLNC---PFQEWMA 454

  Fly   511 PPTYDVGIPQGVILNPLDAICDRKRADAVCVSNLK----NAKKVDKGVLVERPDVKIFLPFRFFV 571
            .|.:                        .|:|..|    |.:|::..:|
Worm   455 QPNF------------------------TCISYDKLENPNPEKIEAEIL---------------- 479

  Fly   572 YEPKALFIPNTYNRFLVVPSGDHLTSLVDEISYISPPAPPLSQIDDIPPEYFCNGD--------- 627
               :|......:....:   ..|..|.:|:..:..|...|          |:.:||
Worm   480 ---QATQFNGGFEEHFI---NMHHDSQMDQFLFQFPWGIP----------YYHDGDMETISTSCS 528

  Fly   628 ------NRPPNCGPNCECTHMVDIPLGAIVEVVL----VDEVQQVNLSHPFHLHGTAFYVVGLG- 681
                  |...:....|.|.:.::..|..||::.|    :........:|||||||..|||:.:|
Worm   529 QTACANNSMSDLDTTCRCFYHLEHKLNNIVQITLYNMGLGGAMGTGYAHPFHLHGHHFYVMKVGW 593

  Fly   682 ----------------RSPDKSIKKINLKHALELDQM-GMLERHFSKPPLK-DTIAVPNNGYVVI 728
                            ..|.:.: ..|.|.....|.: |.||...:|.|.| |||.:|..||:.|
Worm   594 PSYNGSGFIDQMNQDIDCPGRDV-SCNGKKWRNKDWLGGALEAMNTKNPTKRDTITLPVGGYITI 657

  Fly   729 RFRADNPGYWLFHCHFLFHIVIGMNLIFHIGTTADLPPVPPRFP-TCG----DHVP 779
            ||||.|||:|..|||...|::.|....:.:|....:...|..|| .||    |.:|
Worm   658 RFRAVNPGWWFAHCHLELHLMGGTGYAYKVGDQNQIYMPPDNFPHDCGVFKVDKLP 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stw	NP_001137606.1	ascorbase	230..756	CDD:274555	162/649 (25%)
		CuRO_1_tcLCC2_insect_like	230..333	CDD:259927	41/118 (35%)
		CuRO_2_tcLCC_insect_like	352..500	CDD:259951	51/213 (24%)
		CuRO_3_tcLLC2_insect_like	599..767	CDD:259972	55/205 (27%)
F21D5.3	NP_001255321.1	CuRO_1_tcLCC2_insect_like	110..213	CDD:259927	40/102 (39%)
		PLN02191	116..708	CDD:177843	166/666 (25%)
		CuRO_3_tcLLC2_insect_like	500..696	CDD:259972	55/206 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I5086
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I2375
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58299
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	1	1.000	-	-		FOG0000424
OrthoInspector	1	1.000	-	-		otm14491
orthoMCL	1	0.900	-	-		OOG6_100257
Panther	1	1.100	-	-	O	PTHR11709
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R446
SonicParanoid	1	1.000	-	-		X253
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.010