DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stw and Heph

DIOPT Version :9

Sequence 1:	NP_001137606.1	Gene:	stw / 35494	FlyBaseID:	FBgn0286203	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001153099.1	Gene:	Heph / 15203	MGIID:	1332240	Length:	1157	Species:	Mus musculus

Alignment Length:	671	Identity:	131/671 - (19%)
Similarity:	225/671 - (33%)	Gaps:	213/671 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 GPSIQVCENDKVVIDVENHMEGMEVTIHWHGIW----QRGSQYYDGVPFVTQC--PIQQGNTFRY 303
            ||.:|....|.::|.::| ......|||.||::    ..||.|.||.....:.  .:..|.:..|
Mouse   100 GPLLQAEVGDVILIHLKN-FASRPYTIHPHGVFYEKDSEGSLYPDGSSGYLKADDSVPPGGSHVY 163

  Fly   304 QWT---GNAGTH--------FWHAHTGLQK--LDGLYGSVVV--------RQPPSRDPNSH---- 343
            .|:   .:|.|.        .:|:|....:  ..||.|.::.        ..||.|....|
Mouse   164 NWSIPESHAPTEADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGTLDGNSPPQRKDVDHNFFL 228

  Fly   344 ---LYDFDLTTHI-----MLISDWL---HEDAAERYPGRL-AVN---TGQDPESML--------- 384
               :.|.:|:.|:     ...||..   .||.|.:...|: |:|   .|..||..:
Mouse   229 LFSVIDENLSWHLDDNIATYCSDPASVDKEDGAFQDSNRMHAINGFVFGNLPELSMCAQKHVAWH 293

  Fly   385 INGKGQFRDPNTGFMTNTPLEIFTITPGRRYRFRMINAF-ASVCPAQVTIEGHGMTVIATDGEPV 448
            :.|.|...|.:|.|.....|.|      |.:...:.|.| |:...|::..:..|..:|:
Mouse   294 LFGMGNEIDVHTAFFHGQMLSI------RGHHTDVANIFPATFVTAEMVPQKSGTWLIS------ 346

  Fly   449 HPVDVNTIISFSGERYDFVI---SADQPVGAYWIQLRGLGECGIRRAQQLAI----LRYARGPY- 505
              .:||:.:. ||.:..:.:   |.|.||.    ||.|       :.:|..|    :::..||.
Mouse   347 --CEVNSHLR-SGMQAFYKVDSCSMDPPVD----QLTG-------KVRQYFIQAHEIQWDYGPIG 397

  Fly   506 ----------QPASSPPTY------DVGIPQGVILNPLDAICDRKRA--DAVCVSNLKNAKKVDK 552
                      :|.|.|..|      .:|.....:         |..|  |......:...::...
Mouse   398 YDGRTGKSLREPGSGPDKYFQKSSSRIGGTYWKV---------RYEAFQDETFQERVHQEEETHL 453

  Fly   553 GVL--VERPDVKIFLPFRF-------FVYEPKALFIP-----NTYNRFLVVPSGDHLTSLVDEIS 603
            |:|  |.|.:|...:...|       |..:|..:|..     ..||.....|.   :....::::
Mouse   454 GILGPVIRAEVGDTIQVVFYNRASQPFSIQPHGVFYEKNSEGTVYNDGTSHPK---VAKSFEKVT 515

  Fly   604 Y---ISPPAPPLSQIDDIPPE-----YFCNGD-NRPPN---CGPNCECT---------------- 640
            |   :.|.|.|.:|    .|.     ||...| .|..|   .||...|.
Mouse   516 YYWTVPPHAGPTAQ----DPACLTWMYFSAADPTRDTNSGLVGPLLVCKAGALGADGKQKGVDKE 576

  Fly   641 ---------------HMVDIPLGAIVEVVLVDEVQQVNLSHPFH-LHG----------------T 673
                           :..:...|.:...:|.::|:....|:..| ::|                .
Mouse   577 FFLLFTVFDENESWYNNANQAAGMLDSRLLSEDVEGFQDSNRMHAINGFLFSNLPRLDMCKGDTV 641

  Fly   674 AFYVVGLGRSPDKSIKKINLK-HALELDQMGMLERHFSKPPLKDTIAVPNNGYVVIRFRADNPGY 737
            |::::|||...|  :..:..: :.::|..|           .|..:.:..:.:|....:.||||.
Mouse   642 AWHLLGLGTETD--VHGVMFEGNTVQLQGM-----------RKGAVMLFPHTFVTAIMQPDNPGI 693

  Fly   738 WLFHCHFLFHIVIGMNLIFHI 758
            :..:|....|...||..|:::
Mouse   694 FEIYCQAGSHREEGMQAIYNV 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stw	NP_001137606.1	ascorbase	230..756	CDD:274555	130/667 (19%)
		CuRO_1_tcLCC2_insect_like	230..333	CDD:259927	26/114 (23%)
		CuRO_2_tcLCC_insect_like	352..500	CDD:259951	39/176 (22%)
		CuRO_3_tcLLC2_insect_like	599..767	CDD:259972	38/221 (17%)
Heph	NP_001153099.1	CuRO_1_ceruloplasmin	26..208	CDD:259884	26/108 (24%)
		CuRO_2_ceruloplasmin	223..363	CDD:259907	33/154 (21%)
		CuRO_3_ceruloplasmin	377..571	CDD:259886	39/216 (18%)
		Cupredoxin	574..717	CDD:302766	24/154 (16%)
		CuRO_5_ceruloplasmin	732..903	CDD:259887
		Cupredoxin	919..1062	CDD:302766
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010