DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stw and CP

DIOPT Version :9

Sequence 1:	NP_001137606.1	Gene:	stw / 35494	FlyBaseID:	FBgn0286203	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_011510737.1	Gene:	CP / 1356	HGNCID:	2295	Length:	1094	Species:	Homo sapiens

Alignment Length:	808	Identity:	154/808 - (19%)
Similarity:	252/808 - (31%)	Gaps:	248/808 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 FWQQHVATPSSSTPFDSPFFSATHGLVQTHPSIGGSHS------------------GPAPLNGNS 101
            |.::::..|.|    ||..|     ..|....||||:.                  ||...:...
Human   393 FTKENLTAPGS----DSAVF-----FEQGTTRIGGSYKKLVYREYTDASFTNRKERGPEEEHLGI 448

  Fly   102 LGSGAPSSILAGTKPALTAGSG-----YLNSRGSLPTS-----ARYPANKITGTVVEPNPKSPFR 156
            ||            |.:.|..|     ..:::|:.|.|     .|:..|. .||...||.....|
Human   449 LG------------PVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNN-EGTYYSPNYNPQSR 500

  Fly   157 HLDFSTSATAELRR-NPALSAPDECARACREGEPPRIC----YYHF---TLEYYTVLGAACQVCT 213
            .:..|.|..|.... ....:.|.|....  ..:|  :|    ||..   |.:.:|.|....::|.
Human   501 SVPPSASHVAPTETFTYEWTVPKEVGPT--NADP--VCLAKMYYSAVEPTKDIFTGLIGPMKICK 561

  Fly   214 PNATN----------------TVWSHCQCVLADGVERGILTA--------------NRM--IPG- 245
            ..:.:                ||:...:.:|.:...|...||              |:|  :.|
Human   562 KGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGF 626

  Fly   246 -----PSIQVCENDKVVIDVENHMEGMEVTIHWHGIWQRGSQY-YDGVPFVTQCPIQQGNTFRYQ 304
                 |.:.:|:.|.||..:  ...|.|..:  |||:..|:.| :.|....|.....|.:...:.
Human   627 MYGNQPGLTMCKGDSVVWYL--FSAGNEADV--HGIYFSGNTYLWRGERRDTANLFPQTSLTLHM 687

  Fly   305 WTGNAGTHFWHAHTGLQKLDGLYGSVVVRQPPSRDPNSHLYDFDLTTHIMLIS-DWLHEDAAERY 368
            |....||......|......|:.....|.|...:..:|..|..:.|.:|..:. :|.:....| :
Human   688 WPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDSTFYLGERTYYIAAVEVEWDYSPQRE-W 751

  Fly   369 PGRLAVNTGQDPESMLINGKGQFRDPNTGFMTNTPLEIFTITPGRRYR---FRMINAFASVCPAQ 430
            ...|.....|:..:..:: ||:|                  ..|.:|:   :|.........|.:
Human   752 EKELHHLQEQNVSNAFLD-KGEF------------------YIGSKYKKVVYRQYTDSTFRVPVE 797

  Fly   431 VTIEGHGMTVIATDGEPVHPVDVNTIISFSGERYDFVIS--ADQPVGAYWIQLRGLGECGIRRAQ 493
            ...|...:.::   |..:| .||       |::...:..  |.:|   |.|...|:
Human   798 RKAEEEHLGIL---GPQLH-ADV-------GDKVKIIFKNMATRP---YSIHAHGV--------- 839

  Fly   494 QLAILRYARGPYQPASS--PPTYDVGIPQGVILNPLDAICDRKRA---DAVCV-----SNLKNAK 548
                        |..||  .||    :| |..|..:..|.:|..|   |:.|:     |.:...|
Human   840 ------------QTESSTVTPT----LP-GETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVK 887

  Fly   549 KVDKG-----VLVERPDVKIFLPFR-------FFVY-EPKALFIPNTYNRFLVVPSGDHLTSLVD 600
            .:..|     ::..||.:|:|.|.|       |.|: |.::.::.:....:     .||
Human   888 DLYSGLIGPLIVCRRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTY-----SDH------ 941

  Fly   601 EISYISPPAPPLSQIDDIPPEYFCNGDNRPPNCGPNCECTHMVDIPLGAIVEVVLVDEVQQVNLS 665
                     |.....||   |.|...:......|........:.:.:|..|...|:....:::|
Human   942 ---------PEKVNKDD---EEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDL- 993

  Fly   666 HPFHLHGTAFYVVGLGRSPDKSIKKINLKHALELDQMGMLERHFSKPPLKDTIAVPNNGYVVIRF 730
            |..|.||                      |:.:....|:..        .|...:....|..:..
Human   994 HTVHFHG----------------------HSFQYKHRGVYS--------SDVFDIFPGTYQTLEM 1028

  Fly   731 RADNPGYWLFHCHFLFHIVIGMNLIFHI 758
            ....||.||.|||...||..||...:.:
Human  1029 FPRTPGIWLLHCHVTDHIHAGMETTYTV 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stw	NP_001137606.1	ascorbase	230..756	CDD:274555	110/577 (19%)
		CuRO_1_tcLCC2_insect_like	230..333	CDD:259927	26/125 (21%)
		CuRO_2_tcLCC_insect_like	352..500	CDD:259951	23/153 (15%)
		CuRO_3_tcLLC2_insect_like	599..767	CDD:259972	29/160 (18%)
CP	XP_011510737.1	CuRO_1_ceruloplasmin	22..202	CDD:259884
		CuRO_2_ceruloplasmin	214..354	CDD:259907
		CuRO_3_ceruloplasmin	369..572	CDD:259886	41/204 (20%)
		CuRO_4_ceruloplasmin	575..718	CDD:259908	30/146 (21%)
		CuRO_5_ceruloplasmin	732..902	CDD:259887	40/229 (17%)
		CuRO_6_ceruloplasmin	913..1057	CDD:259898	34/198 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12110
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R446
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.040