DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stw and Heph

DIOPT Version :9

Sequence 1:	NP_001137606.1	Gene:	stw / 35494	FlyBaseID:	FBgn0286203	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_579838.1	Gene:	Heph / 117240	RGDID:	71060	Length:	1157	Species:	Rattus norvegicus

Alignment Length:	734	Identity:	137/734 - (18%)
Similarity:	226/734 - (30%)	Gaps:	271/734 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 GPSIQVCENDKVVIDVENHMEGMEVTIHWHGIW----QRGSQYYDGVPFVTQC--PIQQGNTFRY 303
            ||.::....|.::|.::| ......|||.||::    ..||.|.||.....:.  .:..|.:..|
  Rat   100 GPLLKAEMGDVILIHLKN-FASRPYTIHPHGVFYEKDSEGSLYPDGSSGYLKADDSVPPGGSHVY 163

  Fly   304 QWT---GNAGTH--------FWHAHTGLQK--LDGLYGSVVVRQPPSRDPNSHLYDFDLTTHIML 355
            .|:   |:|.|.        .:|:|....:  ..||.|.::..:..:.|.||.....|:..:..|
  Rat   164 NWSIPEGHAPTEADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGTLDGNSPPQRKDVDHNFFL 228

  Fly   356 ISDWLHEDAAERYPGRLAVNTGQDPESMLINGKGQFRDPNTGFMTNTPLEIFTITPGRRYRFRMI 420
            :...:.|:.:......:|... .||.| :....|.|:|.|                    |...|
  Rat   229 LFSVIDENLSWHLDDNIATYC-SDPAS-VDKEDGPFQDSN--------------------RMHAI 271

  Fly   421 NAFA-------SVCPAQVTIEGH--GMTVIATDGEPVHPVDVNT------IISFSGERYD----- 465
            |.|.       |:| ||..:..|  ||.         :.:||:|      .:|..|.|.|
  Rat   272 NGFVFGNLPELSMC-AQKHVAWHLFGMG---------NEIDVHTAFFHGQTLSIRGHRTDVAHIF 326

  Fly   466 ---FV----------------------------------ISADQPVGAYWIQLRGLGECGIRRAQ 493
               ||                                  .|.|.||.    ||.|       :.:
  Rat   327 PATFVTAEMVPQKSGTWLISCVVNSHLKSGMQAFYKVDSCSMDPPVE----QLTG-------KVR 380

  Fly   494 QLAI----LRYARGPY-----------QPASSPPTY------DVGIPQGVILNPLDAICDRKRA- 536
            |..|    :::..||.           :|.|.|..|      .:|.....:         |..|
  Rat   381 QYFIQAHEIQWDYGPIGHDGRTGKSLREPGSGPDKYFQKSSSRIGGTYWKV---------RYEAF 436

  Fly   537 -DAVCVSNLKNAKKVDKGVL--VERPDVKIFLPFRF-------FVYEPKALFIPNT-----YNRF 586
             |......|...::...|:|  |.|.:|...:...|       |..:|..:|...:     ||..
  Rat   437 QDETFQERLHQEEETHLGILGPVIRAEVGDTIQVVFYNRASQPFSIQPHGVFYEKSSEGTVYNDG 501

  Fly   587 LVVPSGDHLTSLVDEISY---ISPPAPPLSQIDDIPPE-----YFCNGD-NRPPN---CGPNCEC 639
            ...|.   :....::::|   :.|.|.|.::    .|.     ||...| .|..|   .||...|
  Rat   502 TSYPK---VAKSFEKVTYYWTVPPHAGPTAE----DPACLTWMYFSAADPTRDTNSGLVGPLLVC 559

  Fly   640 T-------------------------------HMVDIPLGAIVEVVLVDEVQQVNLSHPFH-LHG 672
            .                               :..:...|.:...:|.::|:....|:..| ::|
  Rat   560 KAGALGEDGKQKGVDKEFFLLFTIFDENESWYNNANQAAGMLDSRLLSEDVEGFEDSNRMHAING 624

  Fly   673 ----------------TAFYVVGLGRSPDKSIKKINLK-HALELDQM----GMLERHFSKPPLKD 716
                            .|::::|||...|  :..:..: :.|:|..|    .||..|
  Rat   625 FLFSNLPRLDICKGDTVAWHLLGLGTEND--VHGVMFEGNTLQLQGMRKSAAMLFPH-------- 679

  Fly   717 TIAVPNNGYVVIRFRADNPGYWLFHCHFLFHIVIGMNLIFHIGTTADLPPVPPR----------- 770
                   .:|....:.||||.:..:|....|...||..|:::...:.....|.:
  Rat   680 -------TFVTAIMQPDNPGIFEIYCQAGSHREAGMQAIYNVSQCSSHQDSPRQHYQASRVYYIM 737

  Fly   771 -----FPTCGDHVPPVTWY 784
                 :..|.|....:.||
  Rat   738 AEEIEWDYCPDRSWELEWY 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stw	NP_001137606.1	ascorbase	230..756	CDD:274555	131/688 (19%)
		CuRO_1_tcLCC2_insect_like	230..333	CDD:259927	26/106 (25%)
		CuRO_2_tcLCC_insect_like	352..500	CDD:259951	39/208 (19%)
		CuRO_3_tcLLC2_insect_like	599..767	CDD:259972	40/232 (17%)
Heph	NP_579838.1	CuRO_1_ceruloplasmin	26..208	CDD:259884	26/108 (24%)
		Cupredoxin	223..363	CDD:418529	30/171 (18%)
		CuRO_3_ceruloplasmin	377..571	CDD:259886	39/216 (18%)
		Cupredoxin	574..717	CDD:418529	27/159 (17%)
		CuRO_5_ceruloplasmin	732..903	CDD:259887	4/25 (16%)
		Cupredoxin	919..1062	CDD:418529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010