DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stw and hephl1b

DIOPT Version :9

Sequence 1:	NP_001137606.1	Gene:	stw / 35494	FlyBaseID:	FBgn0286203	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_021335184.1	Gene:	hephl1b / 101886332	ZFINID:	ZDB-GENE-091204-388	Length:	1122	Species:	Danio rerio

Alignment Length:	701	Identity:	126/701 - (17%)
Similarity:	211/701 - (30%)	Gaps:	252/701 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 ELRRNPALSAPDECARACREGEPPRICYYHFT-----LEYYTVLGAACQVCTPNA---------- 216
            :||..|:            |.:||.|.|.:|:     .:..:.|.....||..:|
Zfish   536 KLREGPS------------ESDPPCISYLYFSSSDAVRDTNSGLAGPLLVCKKDALTSSGTQKEV 588

  Fly   217 ------------TNTVWSHCQCVLADGVERG------ILTANRM--IPG------PSIQVCENDK 255
                        .|..|...|.:...|....      ...:|:|  :.|      |.:::.:..:
Zfish   589 DHEFFLLFTVFNENLSWYLDQNIETFGTNESDPENLDFQESNKMHAVNGFMYGNLPGLEMNKGSR 653

  Fly   256 VVIDVENHMEGMEVTIHWHGIWQRGSQYYDGVPFVTQCPIQQGNTFRYQWTGNAGTH---FWHAH 317
                |..|:.|:...:..|||      |:            |||||..|.|    ||   ....|
Zfish   654 ----VRWHLLGLGTEMDIHGI------YF------------QGNTFEKQGT----THDTLSLFPH 692

  Fly   318 TGLQKLDGLYGSVVVRQPPSRDPNSHLYDFDLTTHIMLISDWLHEDAAERYPGRLAVNTGQDPES 382
            |.:         .|..||.....      |:|:..:     |.|.|:..|   :|...||.
Zfish   693 TAV---------TVFMQPDVSGV------FELSCLV-----WDHYDSGMR---QLYEVTGP---- 730

  Fly   383 MLINGKGQFRDPNTG-------FMTNTPLEIFTITPGRRYRFRMIN-----------AFASVCPA 429
                   ::.:|:..       |::...|| :..:|.|.:..:..|           ||..:...
Zfish   731 -------RYEEPSVSPSETVEYFISAEELE-WDYSPDRTWELQNFNTTEDERQVCAIAFVGIAVF 787

  Fly   430 QVTIEGH-----GMTVIATDGEPVHPVDVNTIISFSGERYDFVISADQPVGAYWIQLRGLGECGI 489
            :..::.|     |...:.|.|..:            |.:|..|:            .|...:...
Zfish   788 EWLLKPHFCLSPGSLFVGTGGNKL------------GSKYKKVV------------YREYTDATF 828

  Fly   490 RRAQQLAILRYARGPYQPASSPPTYDVGIPQGVILNPLDAICDRKRADAVCVSNLKNAKKVDKGV 554
            |       .|..|.|::....            ||.|:      .||:...|..:....|.....
Zfish   829 R-------TRIEREPHETHLE------------ILGPM------IRAEVGQVLLITFMNKASHAY 868

  Fly   555 LVERPDVKIFLPFRFFVYEPKALFIPNTYNRFLVVP--SGDHLT-------SLVDEISYISPPAP 610
            .::...|      |.|..:|:|:...|......::|  ||..::       :....:.::...|.
Zfish   869 SIQAHGV------RSFTSKPEAVMPGNMTQYQWIIPEKSGPGVSDPNCIAFAYCSAVDFVKDTAS 927

  Fly   611 PL---------------SQIDDIPPE----YFCNGDNRPPNCGPNCECTHMVDIPLGAIVEVVLV 656
            .|               .|..|:..|    :....:|:......|.|..:....||      :..
Zfish   928 GLIGPLMICRKGTLNQDRQRTDVDREFALLFMVFDENKSWYLEENIESYYNSSEPL------LRD 986

  Fly   657 DEVQQVNLSHPF------HLHG--------TAFYVVGLGRSPDKSIKKINLKHALELDQMGMLER 707
            ||.|:.|..:..      :|.|        ..:|:.|:|...|     |:..| ...:.......
Zfish   987 DEFQKSNKMYGINGKVYANLRGLEMVVGERVVWYLFGMGNEAD-----IHTVH-FHAETFTYKTD 1045

  Fly   708 HFSKPPLKDTIAVPNNGYVVIRFRADNPGYWLFHCHFLFHIVIGMNLIFHI 758
            |..:..:.|.|.   ..:..:...|:..|.||.|||...||:.||:..|.|
Zfish  1046 HTHRTDVYDLIP---GSFQTLEMVAEVNGTWLLHCHVSHHILGGMDTTFII 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stw	NP_001137606.1	ascorbase	230..756	CDD:274555	108/607 (18%)
		CuRO_1_tcLCC2_insect_like	230..333	CDD:259927	24/119 (20%)
		CuRO_2_tcLCC_insect_like	352..500	CDD:259951	25/170 (15%)
		CuRO_3_tcLLC2_insect_like	599..767	CDD:259972	38/193 (20%)
hephl1b	XP_021335184.1	Cupredoxin	26..208	CDD:327505
		Cupredoxin	228..377	CDD:327505
		Cupredoxin	392..586	CDD:327505	13/61 (21%)
		Cupredoxin	589..727	CDD:327505	36/186 (19%)
		Cupredoxin	743..938	CDD:327505	38/250 (15%)
		Cupredoxin	953..1093	CDD:327505	33/154 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D257925at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.110