DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stw and hephl1

DIOPT Version :9

Sequence 1:	NP_001137606.1	Gene:	stw / 35494	FlyBaseID:	FBgn0286203	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_002939767.3	Gene:	hephl1 / 100487896	XenbaseID:	XB-GENE-6037260	Length:	1150	Species:	Xenopus tropicalis

Alignment Length:	712	Identity:	147/712 - (20%)
Similarity:	217/712 - (30%)	Gaps:	280/712 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 IPGPSIQVCENDKVVIDVENHMEGMEVTIHWHGIW----QRGSQYYDGVPFVTQCPIQQGNTFRY 303
            |.||.|:....|.:|:...|:.: .|.:|..||:.    ..|::|.|| ...:...:..|.||.|
Frog   455 ILGPVIKAEVGDTIVVTFANNAD-REFSIMPHGVSFSKDSEGAEYADG-SVKSGARVAAGATFTY 517

  Fly   304 QWT---GNAGTHFWHAHTGLQKLDGLYGSVVVRQPPSRDPNSHL-------------YD------ 346
            .||   ||..|    ||.. |.|..||.|.|   .|.:|..|.|             :|
Frog   518 TWTVPEGNGPT----AHDP-QCLTYLYYSAV---DPVKDTASGLVGPLLVCSKGSLSHDNTQLHV 574

  Fly   347 ----------FD------LTTHIMLISDWL--HEDAA-ERYPGRLAVN---TGQDPE-SMLINGK 388
                      ||      |..:|.:|.::.  .|||. :....|.|:|   .|..|. :|.:.|.
Frog   575 DKEFYLLFTVFDENLSWYLDKNIEMIENFSTDKEDAGFQESNKRHAINGFMFGNLPGLNMCLMGN 639

  Fly   389 ---------------GQFRDPNT---GFMTNTPLEIFTIT-------PGRRYRFRM----INAFA 424
                           |.:.:.||   |.||...:.:|..|       |.:...|.:    .|.:|
Frog   640 VSWHLLGLGTEIDIHGVYFEGNTLDLGGMTRDTVSLFPHTSLTAYMHPDQTGGFEVSCQTTNHYA 704

  Fly   425 S---------VCPAQVTIEGHGMT---VIA---------------------TDGEPVH-PVDVNT 455
            :         :|....|.:.:|..   .||                     |:||..: .:.|:.
Frog   705 NGMKQIYQVDLCNDSNTDQQYGTMRTYFIAAEELEWDYSPDRTWELQKHTFTEGESSYGHIFVSR 769

  Fly   456 IISFSGERYDFVISADQPVGAYWIQLRGLGECGIRRAQQLAILRYARGPY--------------- 505
            ...:.|.:|..|:..:...|.:..|.:...|     .:.|.||    ||:
Frog   770 EGDWIGSKYKKVVYREYTNGQFTEQKKRTPE-----EEHLEIL----GPFIRAEVGDSILIVFKN 825

  Fly   506 --------------------QPASSP---PTYDVGIPQ--GVILNPLD----AICDRKRADAVCV 541
                                ..|:.|   .||...||:  |...|..|    |...|:.......
Frog   826 KATRAYSIHAHGVVEVAAGGNTATQPGAIRTYQWNIPERSGPGANDPDCLTWAYYSRENFIKDIY 890

  Fly   542 SNLKNAK-KVDKGVL--------VERPDVKIFLPFRFFVYEPKALFIPNTYNRFLVVPSGDHLTS 597
            |.|.... ...||||        |:|....:||.|.    |.|:.:
Frog   891 SGLVGPLITCRKGVLNNQGKRKDVDREFAVLFLVFD----ENKSWY------------------- 932

  Fly   598 LVDEISYISPPAPPLSQIDDIPPEYFCNGDNRPPNCGPNCECTHMVDIPLGAIVEVVLVDEVQQV 662
            |.:.|.:.:...|.                                        ||.:.::.|:.
Frog   933 LDENIRFYTHKEPS----------------------------------------EVNVTEKFQES 957

  Fly   663 NLSHPF------HLHG--------TAFYVVGLGRSPDKSIKKINLKHALELDQMGMLERHFSKPP 713
            |..|..      :|||        |.:|::|||...|        .|.:.......:.:. .|..
Frog   958 NKIHAINGKIYGNLHGLTMTEGEKTNWYLLGLGNEID--------MHTVHFHAESFIYKK-DKEH 1013

  Fly   714 LKDTIAVPNNGYVVIRFRADNPGYWLFHCHFLFHIVIGMNLIFHI----------GTTADLP 765
            ..|...:....:..|...|||||.||.|||...||..||..:|.:          |:|...|
Frog  1014 RADVFDLFPGTFQTIELVADNPGTWLLHCHVSDHIHAGMETVFTVKKSGKTILGNGSTTKTP 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stw	NP_001137606.1	ascorbase	230..756	CDD:274555	143/691 (21%)
		CuRO_1_tcLCC2_insect_like	230..333	CDD:259927	32/96 (33%)
		CuRO_2_tcLCC_insect_like	352..500	CDD:259951	42/217 (19%)
		CuRO_3_tcLLC2_insect_like	599..767	CDD:259972	38/191 (20%)
hephl1	XP_002939767.3	Cupredoxin	28..210	CDD:418529
		Cupredoxin	224..363	CDD:418529
		Cupredoxin	376..571	CDD:418529	37/125 (30%)
		Cupredoxin	575..716	CDD:418529	27/140 (19%)
		Cupredoxin	729..902	CDD:418529	30/181 (17%)
		Cupredoxin	917..1058	CDD:418529	41/212 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I11920
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.110