Protein Alignment CG10417 and PPM1E

DIOPT Version :10

• Sequence 1: NP_610169.1
• Gene: CG10417 / 35492
• FlyBaseID: FBgn0033021
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: NP_055721.3
• Gene: PPM1E / 22843
• HGNCID: 19322
• Length: 755
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 124/567 - (21%)
• Similarity: 214/567 - (37%)
• Gaps: 165/567 - (29%)

  Fly   180 GRRAAALAA----------EATNKAVMDPSAKPDGSSTSAAAAAAA------------------- 215
            |..||.:||          |...:|.::...:.:|::|:|||...:
Human    67 GEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLPRPL 131

  Fly   216 ---------------LSADGVANSRNPSNVVNPMAGADSNTTTSINDLSTKNAALKDDSVNDQNE 265
                           |....:.....||.:...:|.|.|:.... :|||.       ..:..:.:
Human   132 SERITREEVEGESLDLCLQQLYKYNCPSFLAAALARATSDEVLQ-SDLSA-------HYIPKETD 188

  Fly   266 GSNGTDFKHTLVSSSNKKLFATGSNDMTELNQSSKNEF-----------TNSSTSKEFERNINSS 319
            |:.||      |.....||..:..:.:.|:..|...:|           |:....|...|.:
Human   189 GTEGT------VEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLYYETSIHAIKNMRRKM--- 244

  Fly   320 QDDEFTDDDADYEENDNVKSPDTSSAESSDCTENDDDGDE-------DGNEDSD----------- 366
                         |:.:|..||      .:...|.:|.:|       ||:...|
Human   245 -------------EDKHVCIPD------FNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHV 290

  Fly   367 ----EEETDED---------QMANDNFCANMIEEPGKDS---GCTAVVCLLQGRDLYVANAGDSR 415
                :|....|         ::.::.|    :::..::|   |.|.||..::|..|:||..|||:
Human   291 NLVRQEMFPHDPAEALCRAFRVTDERF----VQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQ 351

  Fly   416 CVISRSGQAIEMSIDHKPEDDEEASRIIKAGGRVTLDG--RVNGGLNLSRALGDHAYKTNVTLPA 478
            .::.|.|||:|:...|||:.::|..||...||.|...|  ||||.|::|||:||..:|..:...|
Human   352 VMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKPYICGDA 416

  Fly   479 EEQMISALPDIKKLIITPEDEFMVLACDGIWNYMSSEEVVEFVRCRLKDNK-KLSTICEELFDNC 542
                     |....::...:::::|||||.::.::.:|.|:.|...||:|. ..|.:..:|..:.
Human   417 ---------DSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASA 472

  Fly   543 LAPNTMGDGTGCDNMTAVIVQFKKKLQELQSTIPPNQTEDKLLKTSENVSHSLNDQSASKRCASQ 607
                  .|....||:|.::|..:...:.:..:...:.||:......|:......:....||...|
Human   473 ------RDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPWPQ 531

  Fly   608 ---NADADDEILEKNNSKRLKTDLEQENIKDRTP-SPSNQ---NEDP 647
               :|.||           |..|...::..|||. ||.:|   .|||
Human   532 HQCSAPAD-----------LGYDGRVDSFTDRTSLSPGSQINVLEDP 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10417	NP_610169.1	PP2Cc	18..>100	CDD:214625
		PP2Cc	<374..564	CDD:238083	59/195 (30%)
PPM1E	NP_055721.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	21..131		12/63 (19%)
		11 X 2 AA tandem repeats of P-E	31..52
		PP2Cc	230..488	CDD:238083	74/298 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	498..537		6/38 (16%)