Protein Alignment COX4L and AICDA

DIOPT Version :10

• Sequence 1: NP_610168.1
• Gene: COX4L / 35491
• FlyBaseID: FBgn0033020
• Length: 176
• Species: Drosophila melanogaster
• Sequence 2: NP_065712.1
• Gene: AICDA / 57379
• HGNCID: 13203
• Length: 198
• Species: Homo sapiens
• Alignment Length: 132
• Identity: 32/132 - (24%)
• Similarity: 42/132 - (31%)
• Gaps: 52/132 - (39%)

  Fly    66 ELCALREKELDDWKKLSLDEKKQLYR----------YSFCQTYAEFQHITPEWKMCLGVA----- 115
            ||..||  .:.||   .||..: .||          |...:..|:|....|...:.:..|
Human    58 ELLFLR--YISDW---DLDPGR-CYRVTWFTSWSPCYDCARHVADFLRGNPNLSLRIFTARLYFC 116

  Fly   116 ------------LWLVSIGIAISITMKTVLYGKLPDTF----------------NDERQSAQLRR 152
                        |....:.||| :|.|...|  ..:||                |..|.|.||||
Human   117 EDRKAEPEGLRRLHRAGVQIAI-MTFKDYFY--CWNTFVENHERTFKAWEGLHENSVRLSRQLRR 178

  Fly   153 II 154
            |:
Human   179 IL 180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COX4L	NP_610168.1	Cyt_c_Oxidase_IV	35..170	CDD:238462	32/132 (24%)
AICDA	NP_065712.1	Bipartite nuclear localization signal. /evidence=ECO:0000269|PubMed:14769937	1..30
		Interaction with SUPT6H. /evidence=ECO:0000269|PubMed:21518874	2..26
		NAD1	5..180	CDD:465865	31/130 (24%)
		Important for interaction with CTNNBL1. /evidence=ECO:0000269|PubMed:18722174	39..42
		Required for interaction with RNF126. /evidence=ECO:0000269|PubMed:23277564	88..116		5/27 (19%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:14769937	183..198