DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment COX4L and COX4I1

DIOPT Version :9

Sequence 1:	NP_610168.1	Gene:	COX4L / 35491	FlyBaseID:	FBgn0033020	Length:	176	Species:	Drosophila melanogaster
Sequence 2:	XP_024305924.1	Gene:	COX4I1 / 1327	HGNCID:	2265	Length:	175	Species:	Homo sapiens

Alignment Length:	177	Identity:	61/177 - (34%)
Similarity:	95/177 - (53%)	Gaps:	4/177 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLFPCMKLRKLFQMTRRRFASGGDGIRLMVADRQVVGHGINGRPIYFDSPDCPFPAIRY-REVS 64
            |.|...|...::|.:..:|..|....:|   |...||.......|.|.|..|.|.|.:.: :.:|
Human     1 MGLGARMLATRVFSLVGKRAISTSVCVR---AHESVVKSEDFSLPAYMDRRDHPLPEVAHVKHLS 62

  Fly    65 PELCALREKELDDWKKLSLDEKKQLYRYSFCQTYAEFQHITPEWKMCLGVALWLVSIGIAISITM 129
            ....||:|||...|..||:|||.:|||..|.:::||....:.|||..:|.|::.:.....:.:..
Human    63 ASQKALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVIMWQ 127

  Fly   130 KTVLYGKLPDTFNDERQSAQLRRIIQLQMNPITGLASKWCYRENKWK 176
            |..:||.||.:|:.|..:.|.:|::.:::|||.||||||.|.:|:||
Human   128 KHYVYGPLPQSFDKEWVAKQTKRMLDMKVNPIQGLASKWDYEKNEWK 174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COX4L	NP_610168.1	COX4	45..176	CDD:281003	49/131 (37%)
COX4I1	XP_024305924.1	COX4	42..174	CDD:308537	49/131 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151499
Domainoid	1	1.000	111	1.000	Domainoid score	I6239
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37537
Inparanoid	1	1.050	112	1.000	Inparanoid score	I4860
Isobase	1	0.950	-	0	Normalized mean entropy	S5258
OMA	1	1.010	-	-		QHG48902
OrthoDB	1	1.010	-	-		D1591226at2759
OrthoFinder	1	1.000	-	-		FOG0002054
OrthoInspector	1	1.000	-	-		mtm8593
orthoMCL	1	0.900	-	-		OOG6_103849
Panther	1	1.100	-	-	O	PTHR10707
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4386
SonicParanoid	1	1.000	-	-		X922
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.850