DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment COX4L and Aicda

DIOPT Version :9

Sequence 1:	NP_610168.1	Gene:	COX4L / 35491	FlyBaseID:	FBgn0033020	Length:	176	Species:	Drosophila melanogaster
Sequence 2:	NP_033775.1	Gene:	Aicda / 11628	MGIID:	1342279	Length:	198	Species:	Mus musculus

Alignment Length:	134	Identity:	33/134 - (24%)
Similarity:	43/134 - (32%)	Gaps:	56/134 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 ELCALREKELDDWKKLSLDEKKQLYR----------YSFCQTYAEFQHITPEWKMCLGVA-LWL- 118
            ||..||  .:.||   .||..: .||          |...:..|||....|...:.:..| |:.
Mouse    58 ELLFLR--YISDW---DLDPGR-CYRVTWFTSWSPCYDCARHVAEFLRWNPNLSLRIFTARLYFC 116

  Fly   119 -----------------VSIGIAISITMKTVLYGKLPDTF----------------NDERQSAQL 150
                             |.|||   :|.|...|  ..:||                |..|.:.||
Mouse   117 EDRKAEPEGLRRLHRAGVQIGI---MTFKDYFY--CWNTFVENRERTFKAWEGLHENSVRLTRQL 176

  Fly   151 RRII 154
            |||:
Mouse   177 RRIL 180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COX4L	NP_610168.1	COX4	45..176	CDD:281003	33/134 (25%)
Aicda	NP_033775.1	Bipartite nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9GZX7	1..30
		Interaction with SUPT6H. /evidence=ECO:0000250\|UniProtKB:Q9GZX7	2..26
		cytidine_deaminase	5..129	CDD:238610	17/76 (22%)
		APOBEC_N	11..178	CDD:285428	30/130 (23%)
		Important for interaction with CTNNBL1. /evidence=ECO:0000250\|UniProtKB:Q9GZX7	39..42
		Required for interaction with RNF126. /evidence=ECO:0000250\|UniProtKB:Q9GZX7	88..116		7/27 (26%)
		APOBEC_C	124..165	CDD:283020	9/45 (20%)
		Nuclear export signal. /evidence=ECO:0000250\|UniProtKB:Q9GZX7	183..198
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4075
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900