DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10465 and KCTD10

DIOPT Version :9

Sequence 1:	NP_610165.1	Gene:	CG10465 / 35488	FlyBaseID:	FBgn0033017	Length:	301	Species:	Drosophila melanogaster
Sequence 2:	NP_001304324.1	Gene:	KCTD10 / 83892	HGNCID:	23236	Length:	314	Species:	Homo sapiens

Alignment Length:	308	Identity:	195/308 - (63%)
Similarity:	230/308 - (74%)	Gaps:	27/308 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ESMSGDHKI------------LLKG--HSSQYLKLNVGGHLYYTTIGTLTKNNDTMLSAMFSGRM 53
            |.|||:..:            ..||  .||:|:||||||.|||||:.|||| .||||.|||||||
Human     2 EEMSGESVVSSAVPAAATRTTSFKGTSPSSKYVKLNVGGALYYTTMQTLTK-QDTMLKAMFSGRM 65

  Fly    54 EVLTDSEGWILIDRCGNHFGIILNYLRDGTVPLPETNKEIAELLAEAKYYCITELAISCERALYA 118
            ||||||||||||||||.|||.||||||||.|||||:.:||.|||||||||.:..|...|:.||..
Human    66 EVLTDSEGWILIDRCGKHFGTILNYLRDGAVPLPESRREIEELLAEAKYYLVQGLVEECQAALQQ 130

  Fly   119 HQEP-KPICRIPLITSQKEEQLLLSVSLKPAVILVVQRQNNKYSYTSTSDDNLLKNIELFDKLSL 182
            :::. :|.|::|:|||.||||.|::.|.||||.|:..|.||||||||.||||:||||||||||||
Human   131 NKDTYEPFCKVPVITSSKEEQKLIATSNKPAVKLLYNRSNNKYSYTSNSDDNMLKNIELFDKLSL 195

  Fly   183 RFNERILFIKDVIGPSEICCWSFYGHGKKVAEVCCTSIVYATDRKHTKVEFPEARIYEETLQVLL 247
            |||.|:|||||||| .|||||||||.|:|:||||||||||||::|.|||||||||||||||.:||
Human   196 RFNGRVLFIKDVIG-DEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIYEETLNILL 259

  Fly   248 YENRN--APDQELMQATSSARVGSASGTSINQYTSDEEEERTGLARLR 293
            ||.::  .||..|::||     |.|:|.|   :..||:|||..:.|:|
Human   260 YEAQDGRGPDNALLEAT-----GGAAGRS---HHLDEDEERERIERVR 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10465	NP_610165.1	BTB	20..117	CDD:197585	73/96 (76%)
CG10465	NP_610165.1	BTB_2	21..112	CDD:280393	70/90 (78%)
KCTD10	NP_001304324.1	BTB_POZ_KCTD10_BACURD3	26..136	CDD:349707	77/110 (70%)
KCTD10	NP_001304324.1	PCNA-binding. /evidence=ECO:0000250	240..246		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2618
eggNOG	1	0.900	-	-		E1_KOG2716
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32652
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2164
Isobase	1	0.950	-	0	Normalized mean entropy	S3463
OMA	1	1.010	-	-		QHG48414
OrthoDB	1	1.010	-	-		D1306250at2759
OrthoFinder	1	1.000	-	-		FOG0001839
OrthoInspector	1	1.000	-	-		otm42284
orthoMCL	1	0.900	-	-		OOG6_108166
Panther	1	1.100	-	-	LDO	PTHR11145
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5106
SonicParanoid	1	1.000	-	-		X185
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820