Protein Alignment CG10465 and KCTD6

DIOPT Version :10

• Sequence 1: NP_610165.1
• Gene: CG10465 / 35488
• FlyBaseID: FBgn0033017
• Length: 301
• Species: Drosophila melanogaster
• Sequence 2: NP_699162.3
• Gene: KCTD6 / 200845
• HGNCID: 22235
• Length: 237
• Species: Homo sapiens
• Alignment Length: 233
• Identity: 71/233 - (30%)
• Similarity: 107/233 - (45%)
• Gaps: 36/233 - (15%)

  Fly    23 LNVGGHLYYTTIGTLTKNNDTMLSAMFSGRMEVLTDSEGWILIDRCGNHFGIILNYLRDGTVPLP 87
            ||||||||.|::.|||:..|:||.|||.|......|.:|...|||.|..|..:||:||...:.||
Human    16 LNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLP 80

  Fly    88 ETNKEIAELLAEAKYYCITELAISCERALYAHQEPKPICRIPLITSQKEEQL----LLSVSLKPA 148
            ...||...|..||.:|.|..| |.|      ..:|||:  .|:.|.::..:|    .||....|.
Human    81 LDFKEFDLLRKEADFYQIEPL-IQC------LNDPKPL--YPMDTFEEVVELSSTRKLSKYSNPV 136

  Fly   149 VILVVQRQNNKYSYTSTSDDNLLKNIELFDKLSLRFNERILFIKDVIGPSEICCWSF-YGHGKKV 212
            .:::.|..      .:|...:||:.|..:   ..::|:.::..:|       |..|| :|.....
Human   137 AVIITQLT------ITTKVHSLLEGISNY---FTKWNKHMMDTRD-------CQVSFTFGPCDYH 185

  Fly   213 AEVCCT--SIVYATDR----KHTKVEFPEARIYEETLQ 244
            .||...  .:.|.|.:    ::|:|.....|..|.|::
Human   186 QEVSLRVHLMEYITKQGFTIRNTRVHHMSERANENTVE 223

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10465	NP_610165.1	BTB_POZ_KCTD10-like_BACURD	21..112	CDD:349678	41/88 (47%)
KCTD6	NP_699162.3	Interaction with ANK1 isoform Mu17. /evidence=ECO:0000269|PubMed:22573887	1..104		41/88 (47%)
		BTB_POZ_KCTD6	10..113	CDD:349702	45/105 (43%)
		Interaction with CUL3. /evidence=ECO:0000269|PubMed:25974686	10..110		43/100 (43%)
		Interaction with USP21. /evidence=ECO:0000269|PubMed:27621083	113..187		17/89 (19%)