DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sxc and BBS8

DIOPT Version :9

Sequence 1:	NP_523620.1	Gene:	sxc / 35486	FlyBaseID:	FBgn0261403	Length:	1059	Species:	Drosophila melanogaster
Sequence 2:	NP_608524.1	Gene:	BBS8 / 33217	FlyBaseID:	FBgn0031255	Length:	549	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	108/537 - (20%)
Similarity:	178/537 - (33%)	Gaps:	147/537 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 HVEQTRINMQSQGQSHQLPSAAHILLDQN-------PN----------STGSNLVVKQNDIQSLS 49
            ||:......:.:.:.||...|.|.....|       |.          .:|.::::....::.:.
  Fly    43 HVQLFTTKEEEEEEQHQQQQAEHSRFGSNLQRIGPRPRGAAGGGAGAVDSGPSIMMPTWLMEGVW 107

  Fly    50 SVGLLELAHREY--------------QAVDYE---------SAEKHCMQ--------LWRQDSTN 83
            .:.:..|..|.|              :.|::|         |:.|...|        ..:..|..
  Fly   108 QLKMRALTQRVYVDDLDEDDGGNEATEEVEFERIATAARPGSSIKTAFQPRPLTSQRAQQARSRG 172

  Fly    84 TGVLLLLSSIHFQCRRLDKSAQFSTLAIKQNPVLAEAYSNLGNVFKERGQLQEALDNYRRAVRLK 148
            .||      .|....||:.|...|....:....|:...|:||:             ....|.|::
  Fly   173 AGV------AHSSDGRLNSSRPGSAAVARPGTSLSRPGSSLGS-------------RCGTASRIR 218

  Fly   149 PDFIDGYINLAAALVAARDMESAVQAYITALQYNPDLYCVRSDLGNLLKALGR-LEEAKACYLKA 212
                       |...||.::..|......|.:.||.:|..|.   .|:|||.: |...:|...||
  Fly   219 -----------ATSAAAFNVGDATSKLYQASRLNPTIYAERE---TLVKALFQFLYYHEADVQKA 269

  Fly   213 IETC----------PGFAVAWSNLGCVFN-----AQGEIWLAIHH-------FEKAVTLDPNFLD 255
            ...|          |.     .:.||..:     ..|...||:|:       .::::|..|: .|
  Fly   270 HSLCQAVLEVERQKPS-----GSTGCTLSWWWQQQMGRCLLALHYPRRAEPFLQQSLTSFPH-PD 328

  Fly   256 AYINLGNV----------------------------LKEARIF------DRAVAAYLRALNLSPN 286
            .|:.|..|                            |::|||.      :.|:..|..|..|.|.
  Fly   329 TYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQEDALQLYRLAAKLHPI 393

  Fly   287 NAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPNFPDAYCNLANALKEKGQVKEAEDCYNTALRL 351
            |.....::|..|:.....::|:..|||.:.|....|:.|||:|......||:.....|:..||..
  Fly   394 NVESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALAT 458

  Fly   352 CS---NHADSLNNLANIKREQGYIEEATRLYLKALEVFPDFAAAHSNLASVLQQQGKLKEALMHY 413
            .:   ..:|...||:.:....|....|.|.....|.......||.:|||.:..|.|.:..|..:.
  Fly   459 ATQPGQKSDIWYNLSFVAVTSGDFNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGDILGAKSYL 523

  Fly   414 KEAIRIQPTFADAYSNM 430
            ..|..:.|..|:..:|:
  Fly   524 NAAKDVMPDAAEVTTNL 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sxc	NP_523620.1	TPR repeat	53..78	CDD:276809	8/55 (15%)
		TPR_11	86..149	CDD:290150	12/62 (19%)
		TPR repeat	86..112	CDD:276809	6/25 (24%)
		TPR_11	118..183	CDD:290150	10/64 (16%)
		TPR_1	118..151	CDD:278916	5/32 (16%)
		TPR repeat	118..146	CDD:276809	4/27 (15%)
		TPR repeat	151..181	CDD:276809	5/29 (17%)
		TPR_12	182..252	CDD:290160	21/92 (23%)
		TPR_1	192..219	CDD:278916	10/37 (27%)
		TPR_1	220..253	CDD:278916	8/44 (18%)
		TPR repeat	220..248	CDD:276809	6/39 (15%)
		TPR	233..490	CDD:223533	56/242 (23%)
		TPR_1	255..287	CDD:278916	13/65 (20%)
		TPR repeat	255..282	CDD:276809	11/60 (18%)
		TPR repeat	287..317	CDD:276809	7/29 (24%)
		TPR_1	288..321	CDD:278916	7/32 (22%)
		TPR_17	310..342	CDD:290167	11/31 (35%)
		TPR repeat	322..350	CDD:276809	9/27 (33%)
		TPR repeat	355..385	CDD:276809	7/29 (24%)
		TPR_10	356..>385	CDD:290111	7/28 (25%)
		TPR_1	390..423	CDD:278916	10/32 (31%)
		TPR repeat	390..418	CDD:276809	9/27 (33%)
		TPR repeat	423..453	CDD:276809	2/8 (25%)
		TPR_1	424..455	CDD:278916	2/7 (29%)
		TPR_1	458..491	CDD:278916
		TPR repeat	458..486	CDD:276809
		Glyco_transf_41	584..1044	CDD:290556
BBS8	NP_608524.1	TPR repeat	299..322	CDD:276809	4/22 (18%)
		TPR repeat	327..355	CDD:276809	4/27 (15%)
		TPR_16	331..392	CDD:290168	10/60 (17%)
		TPR repeat	365..389	CDD:276809	7/23 (30%)
		Coatomer_WDAD	<378..519	CDD:281977	37/140 (26%)
		TPR_11	394..457	CDD:290150	17/62 (27%)
		TPR repeat	394..424	CDD:276809	7/29 (24%)
		TPR repeat	429..457	CDD:276809	9/27 (33%)
		TPR_11	465..526	CDD:290150	15/60 (25%)
		TPR repeat	466..493	CDD:276809	6/26 (23%)
		TPR repeat	500..526	CDD:276809	8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467060
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840