DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sxc and Ttc13

DIOPT Version :9

Sequence 1:	NP_523620.1	Gene:	sxc / 35486	FlyBaseID:	FBgn0261403	Length:	1059	Species:	Drosophila melanogaster
Sequence 2:	XP_006255864.1	Gene:	Ttc13 / 292095	RGDID:	1310186	Length:	845	Species:	Rattus norvegicus

Alignment Length:	901	Identity:	183/901 - (20%)
Similarity:	307/901 - (34%)	Gaps:	304/901 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SSVGLL--ELAHREYQ--------------AVDYESAEKHCMQLWRQDSTNTGVLLLLSSIHFQC 97
            |.:.||  ||.||:.|              |..|...|...:.....|                |
  Rat    39 SPLSLLKQELQHRQQQEAPAGGGCPQSGDWADQYPECESSFLNFHESD----------------C 87

  Fly    98 RRLDKSAQFSTLAIKQNPVLAEAYSNLGNVFKERGQLQEALDNYRRAVRLKPDFIDGYINLAAAL 162
            .....:...|.|::....:|::|.|     ..|:.:...|.||         |..:..:.:|..|
  Rat    88 ELRGSAPCDSLLSLNTEKILSQAKS-----IAEQKRFPFATDN---------DSTNEELAIAYVL 138

  Fly   163 VAARDMESAVQAYITALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETCPGFAVAWSNLG 227
            |.:...:.|::.:.|.||..|||                   ..|.|        |..:|:...|
  Rat   139 VGSGLYDEAIRHFSTMLQEEPDL-------------------VSAIY--------GRGIAYGKKG 176

  Fly   228 C--VFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALNLSPNNAVV 290
            .  :.||:    ||:....:.:.|:|:             ...:|::      ||..|||
  Rat   177 LHDIKNAE----LALFELSRVIALEPD-------------RPEVFEQ------RAEILSP----- 213

  Fly   291 HGNLACVYYEQGLIDLAIDTYRRAIELQPNFPDAYCNLANALKEKGQVKEAEDCYNTALRLCSNH 355
                      .|.|:.|::...:||:|||:        |...:.:|.:....:.|.||      |
  Rat   214 ----------LGRINEAVNDLTKAIQLQPS--------ARLYRHRGTLYFISEDYATA------H 254

  Fly   356 ADSLNNLANIKREQGYIEEATRLYLKALEVFPDFAAAHSNLASVLQQQGKLKEALMHYKEAIRIQ 420
            .|...:| .:.|.|     .|.:..|.|..|               .:|.||||:..:|||::.:
  Rat   255 EDFQQSL-ELNRNQ-----PTAMLYKGLTFF---------------HRGLLKEAIEAFKEALKQK 298

  Fly   421 PTFADAYSNMGNTLKELQDVSGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIQSYRTAL 485
            ..|.|||.::|...:||.:...|.:.:.:|:.:|............:....|::.||:::::..|
  Rat   299 VDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCL 363

  Fly   486 KLKPDFPDAYCNLAHCLQIVCDWTDYDIRMKKLVSIVTEQ-----------LEKNRLP--SVHPH 537
            :|:|            ...||.:      ||.|..:.|.|           :..:.||  ...|.
  Rat   364 QLEP------------YNEVCQY------MKGLSHVATGQFYEGIKAQTKVMLNDPLPGQKASPE 410

  Fly   538 HSMLYPLTHDCRKAIAARHANLCLEKVHVLHKKPYNFLKKLPTKGRLRIGYLSSDFGNHPTSHL- 601
            :..:..|    |:.....||:|......      ||....||           ..|.:|...:|
  Rat   411 YLRVKYL----REYSRYLHAHLDTPLTE------YNIDTDLP-----------GSFKDHWAKNLP 454

  Fly   602 -----MQSVPGL--HDRSKV------------EIFCYALSPDD--GTTFRHKISRESENFVDLSQ 645
                 .:..|||  |.|..:            |:.|.|    |  |:..::    |:..|:...:
  Rat   455 FLIDGYEEQPGLQPHIRDVLHQNFEGYKPEVQELICVA----DRLGSLMQY----ETPGFLPNKR 511

  Fly   646 I-PCNGKAADKIF----NDGIHILVNMNGYTKGAR-NEIFAL-----RPA-PIQ-VMWLG-YPGT 696
            | ...|.||.::.    ....:..|.|||.|:..: .::|.:     |.| |.| |:||. .|..
  Rat   512 IHRAMGLAALEVMQAVQRTWTNSKVRMNGKTRLMQWRDMFDIAVKWRRIADPDQPVLWLDQMPAP 576

  Fly   697 S-GASFMDYI--ITDSVTSPLELAY-QYSEKLSYMPHTYFIGDHKQMFPHLKERIIVCDKQQSSV 757
            | ...|.::|  |...|   :.:.| :|.||:.:.               :|:||:|.....:.
  Rat   577 SLSRGFNNHINLIRGQV---INMRYLEYFEKILHF---------------IKDRILVYHGANNP- 622

  Fly   758 VDNVTVINATDLSPLVENTDVKEIKEVVNAQKPVEITHKVAE-LPNTTQIVSMIATG-QVQTSLN 820
                                    |.::..::.:|..|||.: ||...|..:....| .|.|.:.
  Rat   623 ------------------------KGLLEVREALEKVHKVEDLLPIMKQFNTKTKDGFTVNTKVP 663

  Fly   821 GVVVQ----NGLATTQTNNKAATGEEVPQNIVITTRRQYMLPDDAVVYCNFNQLYK 872
            .:..|    :|...|.|.:|..       ||:.:...|.......:.:...:.|||
  Rat   664 SLKDQGKEYDGFTITITGDKVG-------NILFSVETQTTEERTQLYHAEIDALYK 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sxc	NP_523620.1	TPR repeat	53..78	CDD:276809	10/40 (25%)
		TPR_11	86..149	CDD:290150	10/62 (16%)
		TPR repeat	86..112	CDD:276809	3/25 (12%)
		TPR_11	118..183	CDD:290150	14/64 (22%)
		TPR_1	118..151	CDD:278916	6/32 (19%)
		TPR repeat	118..146	CDD:276809	6/27 (22%)
		TPR repeat	151..181	CDD:276809	6/29 (21%)
		TPR_12	182..252	CDD:290160	13/71 (18%)
		TPR_1	192..219	CDD:278916	2/26 (8%)
		TPR_1	220..253	CDD:278916	8/34 (24%)
		TPR repeat	220..248	CDD:276809	6/29 (21%)
		TPR	233..490	CDD:223533	55/256 (21%)
		TPR_1	255..287	CDD:278916	6/31 (19%)
		TPR repeat	255..282	CDD:276809	3/26 (12%)
		TPR repeat	287..317	CDD:276809	5/29 (17%)
		TPR_1	288..321	CDD:278916	8/32 (25%)
		TPR_17	310..342	CDD:290167	7/31 (23%)
		TPR repeat	322..350	CDD:276809	5/27 (19%)
		TPR repeat	355..385	CDD:276809	8/29 (28%)
		TPR_10	356..>385	CDD:290111	7/28 (25%)
		TPR_1	390..423	CDD:278916	8/32 (25%)
		TPR repeat	390..418	CDD:276809	8/27 (30%)
		TPR repeat	423..453	CDD:276809	9/29 (31%)
		TPR_1	424..455	CDD:278916	8/30 (27%)
		TPR_1	458..491	CDD:278916	6/32 (19%)
		TPR repeat	458..486	CDD:276809	3/27 (11%)
		Glyco_transf_41	584..1044	CDD:290556	68/335 (20%)
Ttc13	XP_006255864.1	TPR repeat	132..156	CDD:276809	5/23 (22%)
		TPR_11	164..232	CDD:290150	23/113 (20%)
		TPR repeat	164..195	CDD:276809	9/42 (21%)
		TPR_11	200..264	CDD:290150	22/99 (22%)
		TPR repeat	201..229	CDD:276809	10/48 (21%)
		TPR_11	233..296	CDD:290150	22/97 (23%)
		TPR_1	234..266	CDD:278916	8/38 (21%)
		TPR repeat	234..262	CDD:276809	8/34 (24%)
		TPR repeat	267..297	CDD:276809	13/49 (27%)
		TPR_11	270..332	CDD:290150	20/76 (26%)
		TPR_1	302..335	CDD:278916	9/32 (28%)
		TPR repeat	302..329	CDD:276809	7/26 (27%)
		TPR_11	303..367	CDD:290150	14/63 (22%)
		TPR repeat	336..364	CDD:276809	3/27 (11%)
		TPR_11	337..401	CDD:290150	13/81 (16%)
		TPR repeat	370..397	CDD:276809	7/32 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3914
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810