DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sxc and Ttc13

DIOPT Version :9

Sequence 1:	NP_523620.1	Gene:	sxc / 35486	FlyBaseID:	FBgn0261403	Length:	1059	Species:	Drosophila melanogaster
Sequence 2:	NP_001360868.1	Gene:	Ttc13 / 234875	MGIID:	2384573	Length:	845	Species:	Mus musculus

Alignment Length:	902	Identity:	183/902 - (20%)
Similarity:	308/902 - (34%)	Gaps:	306/902 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SSVGLL--ELAHREYQ--------------AVDYESAEKHCMQLWRQDSTNTGVLLLLSSIHFQC 97
            |.:.||  ||.||:.|              |..|...|...:.....|                |
Mouse    39 SPLSLLKQELQHRQQQEAPAGGGCPQSGDWADQYPECESSFLNFHESD----------------C 87

  Fly    98 RRLDKSAQFSTLAIKQNPVLAEAYSNLGNVFKERGQLQEALDNYRRAVRLKPDFIDGYINLAAAL 162
            .....:...|.|::....:|::|.|     ..|:.:...|.||         |..:..:.:|..|
Mouse    88 ELRGSAPCDSLLSLNTEKILSQAKS-----IAEQKRFPFATDN---------DSTNEELAIAYVL 138

  Fly   163 VAARDMESAVQAYITALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETCPGFAVAWSNLG 227
            |.:...:.|::.:.|.||..|||                   ..|.|        |..:|:...|
Mouse   139 VGSGLYDEAIRHFSTMLQEEPDL-------------------VSAIY--------GRGIAYGKKG 176

  Fly   228 C--VFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALNLSPNNAVV 290
            .  :.||:    ||:....:.:.|:|:             ...:|::      ||..|||
Mouse   177 LHDIKNAE----LALFELSRVIALEPD-------------RPEVFEQ------RAEILSP----- 213

  Fly   291 HGNLACVYYEQGLIDLAIDTYRRAIELQPNFPDAYCNLANALKEKGQVKEAEDCYNTALRLCSNH 355
                      .|.|:.|::...:||:|||:        |...:.:|.:....:.|.||      |
Mouse   214 ----------LGRINEAVNDLTKAIQLQPS--------ARLYRHRGTLYFISEDYATA------H 254

  Fly   356 ADSLNNLANIKREQGYIEEATRLYLKALEVFPDFAAAHSNLASVLQQQGKLKEALMHYKEAIRIQ 420
            .|...:| .:.|.|     .|.:..|.|..|               .:|.||||:..:|||::.:
Mouse   255 EDFQQSL-ELNRNQ-----PTAMLYKGLTFF---------------HRGLLKEAIEAFKEALKQK 298

  Fly   421 PTFADAYSNMGNTLKELQDVSGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIQSYRTAL 485
            ..|.|||.::|...:||.:...|.:.:.:|:.:|............:....|::.||:::::..|
Mouse   299 VDFIDAYKSLGQAYRELGNFDAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCL 363

  Fly   486 KLKPDFPDAYCNLAHCLQIVCDWTDYDIRMKKL-----------VSIVTEQLEKNRLP--SVHPH 537
            :|:|            ...||.:      ||.|           :...|:.:..:.||  ...|.
Mouse   364 QLEP------------YNEVCQY------MKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPE 410

  Fly   538 HSMLYPLTHDCRKAIAARHANLCLEKVHVLHKKPYNFLKKLPTKGRLRIGYLSSDFGNHPTSHL- 601
            :..:..|    |:.....||:|......      ||....||           ..|.:|...:|
Mouse   411 YLRVKYL----REYSRYLHAHLDTPLTE------YNIDSDLP-----------GSFKDHWAKNLP 454

  Fly   602 -----MQSVPGL--HDRSKV------------EIFCYALSPDD--GTTFRHKISRESENFVDLSQ 645
                 .:..|||  |.|..:            |:.|.|    |  |:..::    |:..|:...:
Mouse   455 FLIDGYEEQPGLQPHIRDVLHQNFEGYKPEVQELICVA----DRLGSLMQY----ETPGFLPNKR 511

  Fly   646 I-PCNGKAADKIFNDGIH-----ILVNMNGYTKGAR-NEIFAL-----RPA-PIQ-VMWLG-YPG 695
            | ...|.||.::. ..:|     ..|.|||.|:..: .::|.:     |.| |.| |:||. .|.
Mouse   512 IHRAMGLAALEVM-QAVHRTWTNSKVRMNGKTRLLQWRDMFDIAVKWRRIADPDQPVLWLDQMPA 575

  Fly   696 TS-GASFMDYI--ITDSVTSPLELAY-QYSEKLSYMPHTYFIGDHKQMFPHLKERIIVCDKQQSS 756
            .| ...|.::|  |...|   :.:.| :|.||:.:.               :|:||:|.....:.
Mouse   576 PSLSRGFNNHINLIRGQV---INMRYLEYFEKILHF---------------IKDRILVYHGANNP 622

  Fly   757 VVDNVTVINATDLSPLVENTDVKEIKEVVNAQKPVEITHKVAE-LPNTTQIVSMIATG-QVQTSL 819
                                     |.::..::.:|..|||.: ||...|..:....| .|.|.:
Mouse   623 -------------------------KGLLEVREALEKVHKVEDLLPIMKQFNTKTKDGFTVNTKV 662

  Fly   820 NGVVVQ----NGLATTQTNNKAATGEEVPQNIVITTRRQYMLPDDAVVYCNFNQLYK 872
            ..:..|    :|...|.|.:|..       ||:.:...|.......:.:...:.|||
Mouse   663 PSLKDQGKEYDGFTITITGDKVG-------NILFSVETQTTEERTQLYHAEIDALYK 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sxc	NP_523620.1	TPR repeat	53..78	CDD:276809	10/40 (25%)
		TPR_11	86..149	CDD:290150	10/62 (16%)
		TPR repeat	86..112	CDD:276809	3/25 (12%)
		TPR_11	118..183	CDD:290150	14/64 (22%)
		TPR_1	118..151	CDD:278916	6/32 (19%)
		TPR repeat	118..146	CDD:276809	6/27 (22%)
		TPR repeat	151..181	CDD:276809	6/29 (21%)
		TPR_12	182..252	CDD:290160	13/71 (18%)
		TPR_1	192..219	CDD:278916	2/26 (8%)
		TPR_1	220..253	CDD:278916	8/34 (24%)
		TPR repeat	220..248	CDD:276809	6/29 (21%)
		TPR	233..490	CDD:223533	55/256 (21%)
		TPR_1	255..287	CDD:278916	6/31 (19%)
		TPR repeat	255..282	CDD:276809	3/26 (12%)
		TPR repeat	287..317	CDD:276809	5/29 (17%)
		TPR_1	288..321	CDD:278916	8/32 (25%)
		TPR_17	310..342	CDD:290167	7/31 (23%)
		TPR repeat	322..350	CDD:276809	5/27 (19%)
		TPR repeat	355..385	CDD:276809	8/29 (28%)
		TPR_10	356..>385	CDD:290111	7/28 (25%)
		TPR_1	390..423	CDD:278916	8/32 (25%)
		TPR repeat	390..418	CDD:276809	8/27 (30%)
		TPR repeat	423..453	CDD:276809	9/29 (31%)
		TPR_1	424..455	CDD:278916	8/30 (27%)
		TPR_1	458..491	CDD:278916	6/32 (19%)
		TPR repeat	458..486	CDD:276809	3/27 (11%)
		Glyco_transf_41	584..1044	CDD:290556	69/336 (21%)
Ttc13	NP_001360868.1	PEP_TPR_lipo	104..>403	CDD:274350	87/430 (20%)
		TPR repeat	132..156	CDD:276809	5/23 (22%)
		TPR repeat	164..195	CDD:276809	9/42 (21%)
		TPR repeat	201..229	CDD:276809	10/48 (21%)
		TPR repeat	234..262	CDD:276809	8/34 (24%)
		TPR repeat	267..297	CDD:276809	13/49 (27%)
		TPR repeat	302..329	CDD:276809	7/26 (27%)
		TPR repeat	336..364	CDD:276809	3/27 (11%)
		TPR repeat	370..397	CDD:276809	6/32 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3914
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810