DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment d4 and DPF3

DIOPT Version :9

Sequence 1:	NP_610163.1	Gene:	d4 / 35485	FlyBaseID:	FBgn0033015	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001267473.1	Gene:	DPF3 / 8110	HGNCID:	17427	Length:	412	Species:	Homo sapiens

Alignment Length:	419	Identity:	111/419 - (26%)
Similarity:	166/419 - (39%)	Gaps:	147/419 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KIQNF------LNDKEKYKEILENSENFNTRLCIERRLRMPFLDPQTGVAQTHCSLFMKKKQRMP 78
            |::|.      |.| :.|||.:|:..::|:|||.||.:|:||||.||||||.:|.::|:|:.|.|
Human    56 KLENLFHMCTRLGD-QFYKEAIEHCRSYNSRLCAERSVRLPFLDSQTGVAQNNCYIWMEKRHRGP 119

  Fly    79 GLRHGQIYTYPSSRWRKPKRQYLLNP--NQSFRAYQYREHNLQHSHHQTHQHHHHIPSSGVAVPQ 141
            ||..||:||||:..|||.:|   |:|  :...|..:.:                  |...:.:.:
Human   120 GLAPGQLYTYPARCWRKKRR---LHPPEDPKLRLLEIK------------------PEVELPLKK 163

  Fly   142 NPHLAESAAI-AATDGNSMGASGDNDSKDSHANVEKEWFHDEMDTSHFHHGDEFEDDFDSDNDFD 205
            :...:||..: |...|..:....|...::|...:::...:||    :...|:| |:|.:.|..
Human   164 DGFTSESTTLEALLRGEGVEKKVDAREEESIQEIQRVLENDE----NVEEGNE-EEDLEEDIP-- 221

  Fly   206 ESYTSRGKRKKCSRPRRTNANVEGTPKRGRKGGGNRRKNAVEGESDR-----------KRRAGGN 259
                   |||..:|.|          .||..||..|...|.:.:.|:           |.|.|
Human   222 -------KRKNRTRGR----------ARGSAGGRRRHDAASQEDHDKPYVCDICGKRYKNRPG-- 267

  Fly   260 SANTSAAAAAAAAAVAHAACTAAAVASTGLYASHSNSASPIPINDDNSQSGLILPTNISSSYDKT 324
                                       ...:.:|::.||.   ..|.:|.            .:|
Human   268 ---------------------------LSYHYAHTHLASE---EGDEAQD------------QET 290

  Fly   325 SSDAGASNDSIPLATMVAINAGLTTSNVCNAHPVQTGTNQTVFATGNKVKQRVERDIAQPSPYCD 389
            .|.....|::                     |..|.|.:.||.                |:.|||
Human   291 RSPPNHRNEN---------------------HRPQKGPDGTVI----------------PNNYCD 318

  Fly   390 FCLGDQRENKKTNMPEELVSCSDCGRSGH 418
            ||||....|||:..|||||||:|||||.|
Human   319 FCLGGSNMNKKSGRPEELVSCADCGRSAH 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d4	NP_610163.1	Requiem_N	30..98	CDD:290758	37/67 (55%)
		PHD1_d4	387..442	CDD:277091	23/32 (72%)
		PHD2_d4	444..489	CDD:277005
DPF3	NP_001267473.1	Requiem_N	68..139	CDD:290758	38/71 (54%)
DPF3	NP_001267473.1	PHD_SF	316..>347	CDD:304600	22/30 (73%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156494
Domainoid	1	1.000	97	1.000	Domainoid score	I7254
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2840
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49768
OrthoDB	1	1.010	-	-		D312433at33208
OrthoFinder	1	1.000	-	-		FOG0001297
OrthoInspector	1	1.000	-	-		otm40575
orthoMCL	1	0.900	-	-		OOG6_105541
Panther	1	1.100	-	-	LDO	PTHR10615
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5121
SonicParanoid	1	1.000	-	-		X895
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	12.030