DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment d4 and Phf10

DIOPT Version :9

Sequence 1:	NP_610163.1	Gene:	d4 / 35485	FlyBaseID:	FBgn0033015	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_077212.3	Gene:	Phf10 / 72057	MGIID:	1919307	Length:	497	Species:	Mus musculus

Alignment Length:	473	Identity:	109/473 - (23%)
Similarity:	154/473 - (32%)	Gaps:	192/473 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KIQNFLNDKEKYKEILENSENFNTRLCIERRLRMPFLDPQTGVAQTHCSLFMKKKQRMPGLRHGQ 84
            |:..::  |:..|:..|.:.|.|.....|||   .:.|.||.|.|               :..|:
Mouse   194 KVPEYI--KKAAKKAAEFNSNLNRERMEERR---AYFDLQTHVIQ---------------VPQGK 238

  Fly    85 IYTYPSSRWRKPKRQYLLNPNQSFRAYQYREHNLQHSHHQTHQHHHHIPSSGVAVPQNPHLAESA 149
            ....|:.|.:.......|.|.| |:.| |:.::               |.....:|.|..|.|..
Mouse   239 YKVLPTDRTKVSSYPVALIPGQ-FQEY-YKRYS---------------PDELRYLPLNTALYEPP 286

  Fly   150 AIAATDGNSMGASGDNDSKDSHANVEKEWFHDEMDTSHFHHGDEFEDDFDSDNDFDESYTSRGKR 214
            .                                         |......|||.|.|:
Mouse   287 L-----------------------------------------DPELPALDSDGDSDD-------- 302

  Fly   215 KKCSRPRRTNANVEGTPKRGRKGGGNRRKNAVEGESDRKRRAGGNSANTSAAAAAAAAAVAHAAC 279
                               |..|||           |.||:..|.|.::|
Mouse   303 -------------------GEDGGG-----------DEKRKNKGTSDSSS--------------- 322

  Fly   280 TAAAVASTGLYASHSNSASPIPINDDNSQSGLILPTNISSSYDKTSSDAGASNDSIPLATMVAIN 344
                       .:.|...|| |.:.:::..|.      ..|.||             :||
Mouse   323 -----------GNVSEGDSP-PDSQEDTFHGR------QKSKDK-------------MAT----- 351

  Fly   345 AGLTTSNVCNAHPVQTGTNQTVF---ATGNKVKQRVERDIAQPSPYCDFCLGDQRENKKTNMPEE 406
                        |.:.|:.::|.   |.|.|.|       ..|:..|..||..:..||| ...|.
Mouse   352 ------------PRKDGSKRSVLSKSAPGYKPK-------VIPNALCGICLKGKESNKK-GKAES 396

  Fly   407 LVSCSDCGRSGHPSCLQFTANMIISVKRYRWQCIECKYCSICGTSDNDDQLLFCDDCDRGYHMYC 471
            |:.||.|..|||||||..|..::..:|.|.|||:|||.|.|||...::::::|||.||||||.:|
Mouse   397 LIHCSQCDNSGHPSCLDMTMELVSMIKTYPWQCMECKTCIICGQPHHEEEMMFCDVCDRGYHTFC 461

  Fly   472 LSPPLVTPPEGSWSCKLC 489
            :.  |...|.|.|.|..|
Mouse   462 VG--LGAIPSGRWICDCC 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d4	NP_610163.1	Requiem_N	30..98	CDD:290758	15/67 (22%)
		PHD1_d4	387..442	CDD:277091	24/54 (44%)
		PHD2_d4	444..489	CDD:277005	19/44 (43%)
Phf10	NP_077212.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..61
		SAY	88..294		29/177 (16%)
		Essential to induce neural progenitor proliferation	88..184
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..368		31/225 (14%)
		Essential to induce neural progenitor proliferation	291..333		18/106 (17%)
		PHD1_PHF10	379..432	CDD:277003	24/53 (45%)
		PHD2_PHF10	434..477	CDD:277004	19/44 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312433at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010