Protein Alignment d4 and DPF2

DIOPT Version :9

• Sequence 1: NP_610163.1
• Gene: d4 / 35485
• FlyBaseID: FBgn0033015
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: XP_024304405.1
• Gene: DPF2 / 5977
• HGNCID: 9964
• Length: 575
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 190/601 - (31%)
• Similarity: 254/601 - (42%)
• Gaps: 174/601 - (28%)

  Fly    19 EKIQNFLNDKEKYKEILENSENFNTRLCIERRLRMPFLDPQTGVAQTHCSLFMKKKQRMPGLRHG 83
            |.:...|.: :.||:.:|...|:|.|||.||.:|:||||.||||||::|.::|:|:.|.|||..|
Human     6 ENVVKLLGE-QYYKDAMEQCHNYNARLCAERSVRLPFLDSQTGVAQSNCYIWMEKRHRGPGLASG 69

  Fly    84 QIYTYPSSRWRKPKRQY-LLNPNQSFRAYQYREHNLQHSHHQTHQHHHHIPSSGVAVP----QNP 143
            |:|:||:.||||.:|.: ..:|..||       .:::....||.:....|...|.::.    .:|
Human    70 QLYSYPARRWRKKRRAHPPEDPRLSF-------PSIKPDTDQTLKKEGLISQDGSSLEALLRTDP 127

  Fly   144 HLAESAAIAATDGNSMGASGDNDSKDSHANVEKEWFHDEMDTSHFHHGDEFEDDFDSDNDFDESY 208
            .....|.....|.:|:|.....:|:.....:|.               |:|.||.| |.|::|.
Human   128 LEKRGAPDPRVDDDSLGEFPVTNSRARKRILEP---------------DDFLDDLD-DEDYEED- 175

  Fly   209 TSRGKRKKCSRPRRTNANVEGTPKRGRKG-------GGNRRKNAVEGESDRKR------------ 254
                                 ||||..||       |..|:|.......||.:
Human   176 ---------------------TPKRRGKGKSKGKGVGSARKKLDASILEDRDKPYACDSECLTSG 219

  Fly   255 -------------RAGGNSANTSAAAAAAAAAVAHAAC--------------TAAA-------VA 285
                         ..||.............|.|..|.|              |...       :.
Human   220 WVDLALDPAPALDMRGGRVVFLPRVLKQTWALVLPADCFRLRPLGGLGPCYMTGGTCMLWERFLP 284

  Fly   286 STGLYASHSNSASPIPINDDNSQ----------SGLILPTNISSSYDKTS-------SDAGASND 333
            |:|:......:|..:.::.|..|          .||.|..:.|..:...|       |..||.:.
Human   285 SSGVGLLVGATAGRVGLSTDGLQVSWPQLSQGPRGLTLSFSTSVLFFFLSALPHFCPSTLGAPSP 349

  Fly   334 --------SIPLATMVAINAGLTTSN---------------------VCN-------------AH 356
                    ..|.|.....:....:|:                     ||.             ||
Human   350 LGFLSRLLCFPAAAAPVSSVSRPSSHDFSFCLSDSFKQKHTSKAPQRVCGKRYKNRPGLSYHYAH 414

  Fly   357 ---PVQTGTNQTVFATGNKVKQRVERD--------IAQPSPYCDFCLGDQRENKKTNMPEELVSC 410
               ..:.|.::........|.||.|..        :|.|:.||||||||.:.||||..|||||||
Human   415 SHLAEEEGEDKEDSQPPTPVSQRSEEQKSKKGPDGLALPNNYCDFCLGDSKINKKTGQPEELVSC 479

  Fly   411 SDCGRSGHPSCLQFTANMIISVKRYRWQCIECKYCSICGTSDNDDQLLFCDDCDRGYHMYCLSPP 475
            |||||||||||||||..|:.:||.|||||||||.|:|||||:||||||||||||||||||||:|.
Human   480 SDCGRSGHPSCLQFTPVMMAAVKTYRWQCIECKCCNICGTSENDDQLLFCDDCDRGYHMYCLTPS 544

  Fly   476 LVTPPEGSWSCKLCME 491
            :..||||||||.||::
Human   545 MSEPPEGSWSCHLCLD 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
d4	NP_610163.1	Requiem_N	30..98	CDD:290758	37/67 (55%)
		PHD1_d4	387..442	CDD:277091	43/54 (80%)
		PHD2_d4	444..489	CDD:277005	35/44 (80%)
DPF2	XP_024304405.1	Requiem_N	13..79	CDD:316564	33/66 (50%)
		SFP1	<397..417	CDD:227516	4/19 (21%)
		PHD1_DPF2_like	456..511	CDD:277161	43/54 (80%)
		PHD2_d4	513..558	CDD:277005	35/44 (80%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156486
Domainoid	1	1.000	97	1.000	Domainoid score	I7254
eggNOG	1	0.900	-	-		E1_KOG1244
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2840
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49768
OrthoDB	1	1.010	-	-		D312433at33208
OrthoFinder	1	1.000	-	-		FOG0001297
OrthoInspector	1	1.000	-	-		otm40575
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10615
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5121
SonicParanoid	1	1.000	-	-		X895
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.990