DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment d4 and dpf1

DIOPT Version :9

Sequence 1:	NP_610163.1	Gene:	d4 / 35485	FlyBaseID:	FBgn0033015	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001314998.1	Gene:	dpf1 / 566219	ZFINID:	ZDB-GENE-050913-31	Length:	407	Species:	Danio rerio

Alignment Length:	496	Identity:	162/496 - (32%)
Similarity:	217/496 - (43%)	Gaps:	168/496 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 IQNFLNDKEKYKEILENSENFNTRLCIERRLRMPFLDPQTGVAQTHCSLFMKKKQRMPGLRHGQI 85
            |:|.|.: |.|:|.:|:..::|.|||.||.:|:||||.||||||::|.::|:|..|.||:..||:
Zfish    44 IKNSLGE-EFYREAIEHCRSYNARLCAERSMRLPFLDSQTGVAQSNCYIWMEKTHRGPGVAPGQL 107

  Fly    86 YTYPSSRWRKPKRQYLLNPNQ----SFRAYQYREHNLQHSHHQTHQHHHHIPSSGVAVPQNPHLA 146
            ||||:..|||.:|..:|...:    .|:.                .:...:...| .||..|.|.
Zfish   108 YTYPARCWRKKRRLNILEDPRLGPIEFKI----------------DYEAALKKEG-GVPDGPVLE 155

  Fly   147 ESAAIAATDGNSMGASGDNDSKDSHANVEK----EWFHDEMDTSHFHHGDEFEDDFDSDNDFDES 207
                 :...|..:....:...::..:..:|    |:.| |:|.      :|.|:|.
Zfish   156 -----SLLSGELLDKKVETKEEEPMSECQKLLMGEFPH-ELDM------EEMEEDV--------- 199

  Fly   208 YTSRGKRKKCSRPRRTNANVEGTPKRGRKGGGNRRKNAVEGESDR-------------KRRAGGN 259
                        |:|.|.    |..|....||.|::.......||             |.|.|
Zfish   200 ------------PKRKNR----TKGRACGIGGMRKRQDPASLEDRDKPYVCDICGKRYKNRPG-- 246

  Fly   260 SANTSAAAAAAAAAVAHAACTAAAVASTGLYASHSNSASPIPINDDNSQSGLILPTNISSSYDKT 324
                                                                     :|..|..|
Zfish   247 ---------------------------------------------------------LSYHYTHT 254

  Fly   325 S-SDAGASNDSIPLATMVAINAGLTTSNVCNAH--PVQTGTNQTVFATGNKVKQRVERDIAQPSP 386
            . :|.....||                   ..|  |.|...|       :|.|:..:..:. |:.
Zfish   255 HLADEEGEEDS-------------------ERHTLPFQRKNN-------HKPKKAADGSVI-PNG 292

  Fly   387 YCDFCLGDQRENKKTNMPEELVSCSDCGRSGHPSCLQFTANMIISVKRYRWQCIECKYCSICGTS 451
            |||||||.   :|||..||:|:||:||||||||||||||.||..:|:.|||||||||.||:||||
Zfish   293 YCDFCLGG---SKKTGCPEDLISCADCGRSGHPSCLQFTVNMTAAVRTYRWQCIECKSCSLCGTS 354

  Fly   452 DNDDQLLFCDDCDRGYHMYCLSPPLVTPPEGSWSCKLCMEE 492
            :|||||||||||||||||||||||:..||||||||.||:.:
Zfish   355 ENDDQLLFCDDCDRGYHMYCLSPPMSEPPEGSWSCHLCLRQ 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d4	NP_610163.1	Requiem_N	30..98	CDD:290758	35/67 (52%)
		PHD1_d4	387..442	CDD:277091	38/54 (70%)
		PHD2_d4	444..489	CDD:277005	37/44 (84%)
dpf1	NP_001314998.1	Requiem_N	49..120	CDD:290758	36/71 (51%)
		C2H2 Zn finger	234..253	CDD:275368	5/77 (6%)
		PHD1_DPF1	289..346	CDD:277160	40/60 (67%)
		PHD2_d4	347..392	CDD:277005	37/44 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592117
Domainoid	1	1.000	92	1.000	Domainoid score	I7563
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49768
OrthoDB	1	1.010	-	-		D312433at33208
OrthoFinder	1	1.000	-	-		FOG0001297
OrthoInspector	1	1.000	-	-		otm26385
orthoMCL	1	0.900	-	-		OOG6_105541
Panther	1	1.100	-	-	O	PTHR10615
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X895
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.950