DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment d4 and dpf2l

DIOPT Version :9

Sequence 1:	NP_610163.1	Gene:	d4 / 35485	FlyBaseID:	FBgn0033015	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_997861.2	Gene:	dpf2l / 326933	ZFINID:	ZDB-GENE-030131-5132	Length:	405	Species:	Danio rerio

Alignment Length:	508	Identity:	172/508 - (33%)
Similarity:	220/508 - (43%)	Gaps:	162/508 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EKIQNFLNDKEKYKEILENSENFNTRLCIERRLRMPFLDPQTGVAQTHCSLFMKKKQRMPGLRHG 83
            |.|...|.: :.||:.||...|:|.|||.||.:.|||||.||||||::|.::|:|:.|..|...|
Zfish     6 ENIVKVLGE-QYYKDALEQCHNYNARLCAERSILMPFLDSQTGVAQSNCYIWMEKRHRSAGTAPG 69

  Fly    84 QIYTYPSSRWRKPKRQYLLNPNQSFRAYQYREHNLQHSHHQTHQHHHHIPSSGVAVPQNPHLA-- 146
            |:|:||:.||||.:|.:                                      .|::|.|.
Zfish    70 QLYSYPARRWRKKRRAH--------------------------------------PPEDPALVFP 96

  Fly   147 -----------ESAAIAATDGNSMGASGDNDSKDSHANVEKEWFHDE--------MDTSHFHHG- 191
                       :...:...||:|:.|....:..|.....|.....:|        ..|:..|.|
Zfish    97 PLKTAELELGLKKDVLGPLDGSSLEALLKGEPLDKRVTTELRPPEEETSLAEITGTSTASSHSGS 161

  Fly   192 ----------DEFEDDFDSDNDFDESYTSRGKRKKCSRPRRTNANVEGTPKRGRKGGGNRRKNAV 246
                      :::.||.| |.||:|.                      ||||..||
Zfish   162 TRIRKRILEPEDYLDDLD-DEDFEEE----------------------TPKRRSKG--------- 194

  Fly   247 EGESDRKRRAGGNSANTSAAAAAAAAAVAHAACTAAAVASTGLYASHSNSASPIPINDDNSQSGL 311
               ..:.|..|.......|||||........||....       ..:.|            :.||
Zfish   195 ---KSKGRGVGNGKKKLEAAAAAQEDRDKPYACDICG-------KRYKN------------RPGL 237

  Fly   312 ILPTNISSSYDKTSS----DAGASNDSIPLATMVAINAGLTTSNVCNAHPVQTGTNQTVFATGNK 372
                    ||..|.|    :.|...:...:.|              .|.|.:.           |
Zfish   238 --------SYHYTHSHLADEEGEDKEEPEIHT--------------PAPPEEP-----------K 269

  Fly   373 VKQRVERDIAQPSPYCDFCLGDQRENKKTNMPEELVSCSDCGRSGHPSCLQFTANMIISVKRYRW 437
            ..::....:|.|:.||||||||...|:||...||||||||||||||||||||||.|:.:||.|||
Zfish   270 TPKKGPNGLALPNDYCDFCLGDSSMNQKTGQSEELVSCSDCGRSGHPSCLQFTAVMMAAVKTYRW 334

  Fly   438 QCIECKYCSICGTSDNDDQLLFCDDCDRGYHMYCLSPPLVTPPEGSWSCKLCM 490
            ||||||.|::||||:|||||||||||||||||||||||:..||||||||.||:
Zfish   335 QCIECKCCNVCGTSENDDQLLFCDDCDRGYHMYCLSPPMSDPPEGSWSCHLCL 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d4	NP_610163.1	Requiem_N	30..98	CDD:290758	36/67 (54%)
		PHD1_d4	387..442	CDD:277091	42/54 (78%)
		PHD2_d4	444..489	CDD:277005	36/44 (82%)
dpf2l	NP_997861.2	Requiem_N	13..79	CDD:290758	32/66 (48%)
		Peptidase_C19	222..>244	CDD:271592	8/48 (17%)
		PHD1_DPF2_like	284..339	CDD:277161	42/54 (78%)
		PHD2_d4	341..386	CDD:277005	36/44 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592113
Domainoid	1	1.000	134	1.000	Domainoid score	I4964
eggNOG	1	0.900	-	-		E1_KOG1244
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	299	1.000	Inparanoid score	I2677
OMA	1	1.010	-	-		QHG49768
OrthoDB	1	1.010	-	-		D312433at33208
OrthoFinder	1	1.000	-	-		FOG0001297
OrthoInspector	1	1.000	-	-		otm26385
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10615
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X895
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.960