DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment d4 and Tip60

DIOPT Version :9

Sequence 1:	NP_610163.1	Gene:	d4 / 35485	FlyBaseID:	FBgn0033015	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001259234.1	Gene:	Tip60 / 31362	FlyBaseID:	FBgn0026080	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	315	Identity:	67/315 - (21%)
Similarity:	101/315 - (32%)	Gaps:	129/315 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 THQHHHHIPSSGVAVPQNPHLAESAAIAATDGNSMGASGDNDSKDSHANVEKEWFHDEMDTSHFH 189
            |.|.||.:..| |:.|.:|....|.|:||......||||   |....|.:.
  Fly    99 TPQRHHSLAGS-VSRPTSPQHPGSGALAAIPQTPTGASG---SVPPPAGIP-------------- 145

  Fly   190 HGDEFEDDFDSDNDFDESYTSRGKRKKCSRPRRTNANVEGTPKRGRK-GGGNRRKNAVEGESDRK 253
                                             .:....|||..|.: ..||....|::...:||
  Fly   146 ---------------------------------NSVAPPGTPSSGGELVNGNNLAAALQKRINRK 177

  Fly   254 RRAGGNSANTSAAAAAAAAAVAHAACTAAAVASTGLYASHSN-------SASPIPINDDNSQSGL 311
            |:..|.||:            .|.:.|:..      ..||.:       :|:|:.:..|    ||
  Fly   178 RKNHGGSAH------------GHHSLTSQQ------QQSHPHPTTPQTPTATPVHVTGD----GL 220

  Fly   312 ILPTNISSSYDKTSSDAGASNDSIPLATMVAINAGLTTSNVCNAHPVQTG---TNQTVFATGNKV 373
            |               :||:||.           |..:.:.....|.|:|   |:|....|..|.
  Fly   221 I---------------SGAANDD-----------GDGSQDGKTPTPRQSGSMVTHQDDVVTRMKN 259

  Fly   374 KQRVE--RDIAQP---SPY------------CDFCLGDQRENKKTNMPEELVSCS 411
            .:.:|  |...:|   |||            |:||| ..|:::|. :...|..|:
  Fly   260 VEMIELGRHRIKPWYFSPYPQELCQMPCIYICEFCL-KYRKSRKC-LERHLSKCN 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d4	NP_610163.1	Requiem_N	30..98	CDD:290758
		PHD1_d4	387..442	CDD:277091	9/37 (24%)
		PHD2_d4	444..489	CDD:277005
Tip60	NP_001259234.1	Tudor-knot	23..78	CDD:288553
		Drf_FH1	84..>157	CDD:283903	21/108 (19%)
		PHA01732	139..>196	CDD:222828	16/121 (13%)
		NAT_SF	254..533	CDD:302625	16/61 (26%)
		MOZ_SAS	316..500	CDD:280097
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463869
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930