Protein Alignment d4 and Kat6a

DIOPT Version :10

• Sequence 1: NP_610163.1
• Gene: d4 / 35485
• FlyBaseID: FBgn0033015
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: NP_001094040.1
• Gene: Kat6a / 306571
• RGDID: 1304892
• Length: 1998
• Species: Rattus norvegicus
• Alignment Length: 253
• Identity: 82/253 - (32%)
• Similarity: 118/253 - (46%)
• Gaps: 44/253 - (17%)

  Fly   280 TAAAVASTGL--YASHSNS---ASPIPIND---DNSQS------------GLI---------LPT 315
            |...|::.||  |....|.   |.|.|.|.   ||.||            ||.         :..
  Rat    59 TILKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDNKQSVDWNKLLKRAFEGLAESGGSTLKSIER 123

  Fly   316 NISSSYDKTSSDAGASNDSIPLATMVAINAGLTTSNVCNAHPVQTGTNQTVFATGNK-------- 372
            .:.|..|.:::..|.:.........:||...:....:....|:.....:...|.|.:
  Rat   124 FLKSQKDVSAACGGTAASGFHQQLRLAIKRAVGHGRLLKDGPLYRLNTKAANAEGKEGCESLSCL 188

  Fly   373 -----VKQRVERDIAQPSPYCDFCLGDQRENKKTNMPEELVSCSDCGRSGHPSCLQFTANMIISV 432
                 :....::.:|:|.|.|.||||.:.:|:: ..||:|:||:|||.|||||||:|:..:.:.|
  Rat   189 PPVSLLPHEKDKPVAEPIPICSFCLGTKEQNRE-KKPEDLISCADCGNSGHPSCLKFSPELTVRV 252

  Fly   433 KRYRWQCIECKYCSIC-GTSDNDDQLLFCDDCDRGYHMYCLSPPLVTPPEGSWSCKLC 489
            :..||||||||.||.| ....|.|.:||||.||||:||.|..|||...|:|.|.|::|
  Rat   253 RALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQIC 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
d4	NP_610163.1	DPF1-3_N	31..93	CDD:464074
		PHD1_d4	387..442	CDD:277091	28/54 (52%)
		PHD2_d4	444..489	CDD:277005	23/45 (51%)
Kat6a	NP_001094040.1	Required for activation of RUNX1-1. /evidence=ECO:0000250|UniProtKB:Q92794	1..144		19/84 (23%)
		Required for nuclear localization. /evidence=ECO:0000250	52..166		21/106 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	72..93		5/20 (25%)
		H15	85..162	CDD:197772	13/76 (17%)
		Interaction with PML. /evidence=ECO:0000250	144..662		63/168 (38%)
		PHD1_MOZ_MORF	205..262	CDD:277090	30/57 (53%)
		PHD2_KAT6A_6B	264..310	CDD:277002	23/45 (51%)
		Interaction with RUNX1-1. /evidence=ECO:0000250	312..662
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	336..377
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	440..464
		Catalytic. /evidence=ECO:0000250	486..776
		PLN00104	<502..776	CDD:215056
		Mediates interaction with BRPF1, required for histone H3 acetyltransferase activity. /evidence=ECO:0000250	505..808
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	783..947
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	982..1079
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1096..1175
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1195..1436
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1450..1567
		Interaction with PML. /evidence=ECO:0000250	1510..1735
		Interaction with RUNX1-2. /evidence=ECO:0000250	1510..1635
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1630..1702
		Required for activation of RUNX1-2. /evidence=ECO:0000250	1907..1942