DRSC/TRiP Functional Genomics Resources

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Protein Alignment d4 and Kat6a

DIOPT Version :9

Sequence 1:NP_610163.1 Gene:d4 / 35485 FlyBaseID:FBgn0033015 Length:497 Species:Drosophila melanogaster
Sequence 2:NP_001074618.1 Gene:Kat6a / 244349 MGIID:2442415 Length:2003 Species:Mus musculus


Alignment Length:113 Identity:61/113 - (53%)
Similarity:79/113 - (69%) Gaps:2/113 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly   378 ERDIAQPSPYCDFCLGDQRENKKTNMPEELVSCSDCGRSGHPSCLQFTANMIISVKRYRWQCIEC 442
            ::.:|:|.|.|.||||.:.:|:: ..|||||||:|||.|||||||:|:..:.:.||..|||||||
Mouse   199 DKPVAEPIPICSFCLGTKEQNRE-KQPEELVSCADCGNSGHPSCLKFSPELTVRVKALRWQCIEC 262

  Fly   443 KYCSIC-GTSDNDDQLLFCDDCDRGYHMYCLSPPLVTPPEGSWSCKLC 489
            |.||.| ....|.|.:||||.||||:||.|..|||...|:|.|.|::|
Mouse   263 KTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQIC 310

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
d4NP_610163.1 Requiem_N 30..98 CDD:290758
PHD1_d4 387..442 CDD:277091 31/54 (57%)
PHD2_d4 444..489 CDD:277005 23/45 (51%)
Kat6aNP_001074618.1 Required for activation of RUNX1-1. /evidence=ECO:0000250|UniProtKB:Q92794 1..144
Required for nuclear localization. /evidence=ECO:0000250 52..166
H15 85..162 CDD:197772
Interaction with PML. /evidence=ECO:0000250 144..663 61/113 (54%)
PHD1_MOZ_MORF 205..262 CDD:277090 33/57 (58%)
PHD2_KAT6A_6B 264..310 CDD:277002 23/45 (51%)
Interaction with RUNX1-1. /evidence=ECO:0000250 312..663
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 336..377
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 439..466
Catalytic. /evidence=ECO:0000250 487..777
MOZ_SAS <503..777 CDD:332306
Mediates interaction with BRPF1, required for histone H3 acetyltransferase activity. /evidence=ECO:0000250 506..809
Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q92794 644..648
Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q92794 653..659
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 784..939
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 983..1083
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1096..1174
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1197..1438
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1455..1533
Interaction with PML. /evidence=ECO:0000250 1511..1740
Interaction with RUNX1-2. /evidence=ECO:0000250 1511..1636
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1546..1568
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1631..1707
Required for activation of RUNX1-2. /evidence=ECO:0000250 1912..1947
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167846915
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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