Protein Alignment d4 and KAT6B

DIOPT Version :10

• Sequence 1: NP_610163.1
• Gene: d4 / 35485
• FlyBaseID: FBgn0033015
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: NP_036462.2
• Gene: KAT6B / 23522
• HGNCID: 17582
• Length: 2073
• Species: Homo sapiens
• Alignment Length: 109
• Identity: 60/109 - (55%)
• Similarity: 73/109 - (66%)
• Gaps: 2/109 - (1%)

  Fly   382 AQPSPYCDFCLGDQRENKKTNMPEELVSCSDCGRSGHPSCLQFTANMIISVKRYRWQCIECKYCS 446
            |.|.|.|.||||.:..|:: ..||||:||:|||.|||||||:|...:..:||..||||||||.||
Human   210 ADPIPICSFCLGTKESNRE-KKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCIECKTCS 273

  Fly   447 ICGTSD-NDDQLLFCDDCDRGYHMYCLSPPLVTPPEGSWSCKLC 489
            .|.... |.|.:||||.||||:||.|..|||...|:|.|.|::|
Human   274 ACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVC 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
d4	NP_610163.1	DPF1-3_N	31..93	CDD:464074
		PHD1_d4	387..442	CDD:277091	30/54 (56%)
		PHD2_d4	444..489	CDD:277005	23/45 (51%)
KAT6B	NP_036462.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	72..97
		H15	113..167	CDD:197772
		PHD1_MOZ_MORF	212..269	CDD:277090	32/57 (56%)
		PHD2_KAT6A_6B	271..317	CDD:277002	23/45 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..409
		Negatively regulates HAT activity	361..717
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	442..531
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	553..583
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..663
		Catalytic	718..1008
		PLN00104	<721..989	CDD:215056
		Interaction with BRPF1. /evidence=ECO:0000269|PubMed:18794358	752..1008
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1022..1452
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1484..1538
		Interaction with RUNX1 and RUNX2. /evidence=ECO:0000269|PubMed:11965546	1560..2073
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1580..1619