DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment d4 and Dpf2

DIOPT Version :9

Sequence 1:	NP_610163.1	Gene:	d4 / 35485	FlyBaseID:	FBgn0033015	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001278007.1	Gene:	Dpf2 / 19708	MGIID:	109529	Length:	405	Species:	Mus musculus

Alignment Length:	496	Identity:	173/496 - (34%)
Similarity:	237/496 - (47%)	Gaps:	134/496 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EKIQNFLNDKEKYKEILENSENFNTRLCIERRLRMPFLDPQTGVAQTHCSLFMKKKQRMPGLRHG 83
            |.:...|.: :.||:.:|...|:|.|||.||.:|:||||.||||||::|.::|:|:.|.|||..|
Mouse     6 ENVVKLLGE-QYYKDAMEQCHNYNARLCAERSVRLPFLDSQTGVAQSNCYIWMEKRHRGPGLASG 69

  Fly    84 QIYTYPSSRWRKPKRQY-LLNPNQSFRAYQYREHNLQHSHHQTHQHHHHIPSSGVAVP----QNP 143
            |:|:||:.||||.:|.: ..:|..||       .:::....||.:....|...|.::.    .:|
Mouse    70 QLYSYPARRWRKKRRAHPPEDPRLSF-------PSIKPDTDQTLKKEGLISQDGSSLEALLRTDP 127

  Fly   144 HLAESAAIAATDGNSMGASGDNDSKDSHANVEKEWFHDEMDTSHFHHGDEFEDDFDSDNDFDESY 208
            .....|.....|.:|:|....::|:.....:|.               |:|.||.| |.|::|.
Mouse   128 LEKRGAPDPRVDDDSLGEFPVSNSRARKRIIEP---------------DDFLDDLD-DEDYEED- 175

  Fly   209 TSRGKRKKCSRPRRTNANVEGTPKRGRKGGGNRRKNAVEGESDRKRR-------------AGGNS 260
                                 ||||..||     |:..:|.|..:::             |..||
Mouse   176 ---------------------TPKRRGKG-----KSKSKGVSSARKKLDASILEDRDKPYACDNS 214

  Fly   261 ---ANTSAAAAAAAAAVAHAACTAAAVASTGL--YASHSNSASPIPINDDNSQSGLILPTNISSS 320
               .:||.|        ....|........||  :.:||:.|.....:.::|:.    ||.:|..
Mouse   215 FKQKHTSKA--------PQRVCGKRYKNRPGLSYHYAHSHLAEEEGEDKEDSRP----PTPVSQR 267

  Fly   321 YDKTSSDAGASNDSIPLATMVAINAGLTTSNVCNAHPVQTGTNQTVFATGNKVKQRVERDIAQPS 385
            .::..|..|...                                                :|.|:
Mouse   268 SEEQKSKKGPDG------------------------------------------------LALPN 284

  Fly   386 PYCDFCLGDQRENKKTNMPEELVSCSDCGRSGHPSCLQFTANMIISVKRYRWQCIECKYCSICGT 450
            .||||||||.:.||||..||||||||||||||||||||||..|:.:||.|||||||||.|::|||
Mouse   285 NYCDFCLGDSKINKKTGQPEELVSCSDCGRSGHPSCLQFTPVMMAAVKTYRWQCIECKCCNLCGT 349

  Fly   451 SDNDDQLLFCDDCDRGYHMYCLSPPLVTPPEGSWSCKLCME 491
            |:||||||||||||||||||||:|.:..||||||||.||::
Mouse   350 SENDDQLLFCDDCDRGYHMYCLTPSMSEPPEGSWSCHLCLD 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d4	NP_610163.1	Requiem_N	30..98	CDD:290758	37/67 (55%)
		PHD1_d4	387..442	CDD:277091	43/54 (80%)
		PHD2_d4	444..489	CDD:277005	34/44 (77%)
Dpf2	NP_001278007.1	Requiem_N	13..79	CDD:290758	33/66 (50%)
		PHD1_DPF2_like	286..341	CDD:277161	43/54 (80%)
		PHD2_d4	343..388	CDD:277005	34/44 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846909
Domainoid	1	1.000	101	1.000	Domainoid score	I6910
eggNOG	1	0.900	-	-		E1_KOG1244
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	299	1.000	Inparanoid score	I2682
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49768
OrthoDB	1	1.010	-	-		D312433at33208
OrthoFinder	1	1.000	-	-		FOG0001297
OrthoInspector	1	1.000	-	-		otm42647
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10615
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5121
SonicParanoid	1	1.000	-	-		X895
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.990