DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nipped-A and TRRAP

DIOPT Version :9

Sequence 1:	NP_001097192.2	Gene:	Nipped-A / 35483	FlyBaseID:	FBgn0053554	Length:	3790	Species:	Drosophila melanogaster
Sequence 2:	NP_001362453.1	Gene:	TRRAP / 8295	HGNCID:	12347	Length:	3873	Species:	Homo sapiens

Alignment Length:	3935	Identity:	2037/3935 - (51%)
Similarity:	2725/3935 - (69%)	Gaps:	238/3935 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FRNYLNILNDSSSKDELKLKATQELSEHFEMIMQSPAYPSFLDNSLKIFMRILQDGEPQFIQENT 76
            :..::..|.|.::.||.|||..||:||:||.:..||.|.:||::.:..|:..|||||.||:||..
Human    21 YLQFVAALTDVNTPDETKLKMMQEVSENFENVTSSPQYSTFLEHIIPRFLTFLQDGEVQFLQEKP 85

  Fly    77 MQHIRKLILEMIHRLPITESLRQHVKTIITMMLKILKTDNEENVLVCLRIIIELHKHFRPSFNSE 141
            .|.:|||:||:|||:|..|.||.|.|.::::|.:.|:|:||||||:||||||||||.|||....|
Human    86 AQQLRKLVLEIIHRIPTNEHLRPHTKNVLSVMFRFLETENEENVLICLRIIIELHKQFRPPITQE 150

  Fly   142 IQLFLGFVKEIYTNLPNHLTSIFETSNDVWVTDLKDLNLEVLLSESY-------SVRTIHVEKAL 199
            |..||.|||:||..||..:...||             |.:|:...:.       .:.||.|:...
Human   151 IHHFLDFVKQIYKELPKVVNRYFE-------------NPQVIPENTVPPPEMVGMITTIAVKVNP 202

  Fly   200 D-SNSQQQIYNLLPRGILSLKVLQELPIIVVLMYQIYKNAVHQEVSEFIPLILTTINLQPTVTRR 263
            : .:|:.:.::::|||.||||||.|||||||||||:||..:|..|:||:|||:.||.:|.:...|
Human   203 EREDSETRTHSIIPRGSLSLKVLAELPIIVVLMYQLYKLNIHNVVAEFVPLIMNTIAIQVSAQAR 267

  Fly   264 NSP--QKEIYVEFMGAQIKTLSFLAYIVRIFQEVVIASSLSVTSGMLNLMKNCPKEAAHLRKELL 326
            ...  .||:|.:|:.||||||||||||:||:||:|...|..:..|||.|:.|||.|.||||||||
Human   268 QHKLYNKELYADFIAAQIKTLSFLAYIIRIYQELVTKYSQQMVKGMLQLLSNCPAETAHLRKELL 332

  Fly   327 IAARHIFATDLRQKFIPSIEQLFDEDLLIGKGVTL-DSIRPLAYSTLADLAHHVRQSLNIDVLIK 390
            |||:||..|:||.:|||.:::||||.:|||.|.|. :::|||||||||||.|||||.|.:..|..
Human   333 IAAKHILTTELRNQFIPCMDKLFDESILIGSGYTARETLRPLAYSTLADLVHHVRQHLPLSDLSL 397

  Fly   391 AVNLFSKNVHDESLAVGIQTMSCKLLLNLVDCLRHHSETEPQRSKALLSKLLKVFVKKFETIAKI 455
            ||.||:||:.||||...|||||||||||||||:|..||.|....:.:|.::|:|||.||.|||:.
Human   398 AVQLFAKNIDDESLPSSIQTMSCKLLLNLVDCIRSKSEQESGNGRDVLMRMLEVFVLKFHTIARY 462

  Fly   456 QLPLIIQKCKGHAFSGAL----------VNSSGNA-SLSHINAPDL------------------- 490
            ||..|.:|||..:..||:          ..:.|.| |.:.:.||..
Human   463 QLSAIFKKCKPQSELGAVEAALPGVPTAPAAPGPAPSPAPVPAPPPPPPPPPPATPVTPAPVPPF 527

  Fly   491 -------KDDISNIQVSASGSQWIYSVNVAEFRSLVKTLVGGVKTITWGFFNSKFQLTDTKLANH 548
                   |:|....||:             :.||||||||.||||||||..:.|.......:.|
Human   528 EKQGEKDKEDKQTFQVT-------------DCRSLVKTLVCGVKTITWGITSCKAPGEAQFIPN- 578

  Fly   549 EKIFGPEIVCSYIDLVYYAMEALDIYTINVNPNQQRTSGLIS----RSKEEKEVLEHFSGIFLMM 609
             |...|:....||.||.|||:|||||.:.:..|.|....:.:    |.||||||||||:|:|.||
Human   579 -KQLQPKETQIYIKLVKYAMQALDIYQVQIAGNGQTYIRVANCQTVRMKEEKEVLEHFAGVFTMM 642

  Fly   610 HSQNFQEIFSTTINFLVERIYKNQSLQVIANSFLANPTTSPLFATVLVEYLLNKMEEMGSNLERS 674
            :...|:|||.||:.::||||.||.:||::|||||||||||.||||:||||||:::.|||||:|.|
Human   643 NPLTFKEIFQTTVPYMVERISKNYALQIVANSFLANPTTSALFATILVEYLLDRLPEMGSNVELS 707

  Fly   675 NLYLRLFKLVFGSVSLFPVENEQMLRPHLHKIVNRSMELALISEEPYNYFLLLRALFRSIGGGSH 739
            ||||:||||||||||||..||||||:||||||||.|||||..::|||||||||||||||||||||
Human   708 NLYLKLFKLVFGSVSLFAAENEQMLKPHLHKIVNSSMELAQTAKEPYNYFLLLRALFRSIGGGSH 772

  Fly   740 DLLYQEFLPLLPNLLEGLNRLQSGFHKQHMRDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNG 804
            |||||||||||||||:|||.||||.|||||:||||||||||||||||||||||||||||||||||
Human   773 DLLYQEFLPLLPNLLQGLNMLQSGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNG 837

  Fly   805 SPTLISQGLRTLELCVDNLQPDFLYDHIQPVRAALMQALWKTLRN-QDNAALVAFRVLGKFGGGN 868
            |.||:||||||||||||||||||||||||||||.||||||:|||| .|:.:.||:||||||||.|
Human   838 SQTLVSQGLRTLELCVDNLQPDFLYDHIQPVRAELMQALWRTLRNPADSISHVAYRVLGKFGGSN 902

  Fly   869 RKMMVEPQALSYIINDKPTISIVTYFQEYETPIDFPVDEAIKSAFRALGSNSTDQFYRRQSWEVI 933
            |||:.|.|.|.|::.:....||...|.:.:..:..|:::||::|...|.|.:|:.:||||:||||
Human   903 RKMLKESQKLHYVVTEVQGPSITVEFSDCKASLQLPMEKAIETALDCLKSANTEPYYRRQAWEVI 967

  Fly   934 RCFLAAFISLDDEKHMLLKLFTHVDFVENKIMN-WSTFQHKAGNETVRETHQTALIGMLVASATK 997
            :|||.|.:||:|.||.|.:|..|.:|.|..|.| ..:.::||.:...|:|.:.||.|..:::..|
Human   968 KCFLVAMMSLEDNKHALYQLLAHPNFTEKTIPNVIISHRYKAQDTPARKTFEQALTGAFMSAVIK 1032

  Fly   998 DLRDSVCPVMAAVVRHYTMVAIAQQAGPFPQKGYQ---------------ATHGIDPMILIDALA 1047
            |||.|..|.:|:::|||||||:|||.|||....||               .:.|:||::||||:|
Human  1033 DLRPSALPFVASLIRHYTMVAVAQQCGPFLLPCYQVGSQPSTAMFHSEENGSKGMDPLVLIDAIA 1097

  Fly  1048 SCMGHEEKELCKPGIACMGIILDTATNIMGNKDRACKLPIIQYLAEKMVSLCYDRPWYSKVGGCQ 1112
            .||.:|||||||.|...:.:|.|.|:.|:|:|:|||:||:..|:.|::.:.||::.||:|:||..
Human  1098 ICMAYEEKELCKIGEVALAVIFDVASIILGSKERACQLPLFSYIVERLCACCYEQAWYAKLGGVV 1162

  Fly  1113 AIQFLCKHMSLRALFQNLFNFLKAFMFVLMDLEGDVSNGAIEITKSYMKSMLEICLTPINECYKN 1177
            :|:||.:.:.|..:.||...||||.:||:|||.|:|||||:.:.|:.::.:|..|.||:.:..:.
Human  1163 SIKFLMERLPLTWVLQNQQTFLKALLFVMMDLTGEVSNGAVAMAKTTLEQLLMRCATPLKDEERA 1227

  Fly  1178 IDLKDLQAKATYEVIHELVRHITSPNTIVREESMVLLKHIGTIQSKTVSEVMDPHKDVLADIIPP 1242
            .::...|.|:.:.|.|:|||.:||||:.||:::|..|:.:..:..|:|:.:|:|||:||.|::||
Human  1228 EEIVAAQEKSFHHVTHDLVREVTSPNSTVRKQAMHSLQVLAQVTGKSVTVIMEPHKEVLQDMVPP 1292

  Fly  1243 KKHLLRHQPANAQIGLMDGNTFCTTLEPRLFTIDLTNTYHKLFFHELLTLSEAEDATLAKLDCYK 1307
            |||||||||||||||||:||||||||:|||||:||....||:|:.|||.|.||||:.|.||.|||
Human  1293 KKHLLRHQPANAQIGLMEGNTFCTTLQPRLFTMDLNVVEHKVFYTELLNLCEAEDSALTKLPCYK 1357

  Fly  1308 NVPNLIPLRTSALRALAACHYISDIGYKEKIINIIFKVMESDKSELQTTAFHCMKHFITGVTLEK 1372
            ::|:|:|||.:||.|||||:|:..  .:||||..:||.:.|..||||.....||:.|:.|.|:|.
Human  1358 SLPSLVPLRIAALNALAACNYLPQ--SREKIIAALFKALNSTNSELQEAGEACMRKFLEGATIEV 1420

  Fly  1373 EKVQSAMRPLLLKLGDHRNLSIPAIKRLSYFTQIFPQMFNEKLSEQILQHCSKIMEIFVSEYKS- 1436
            :::.:.|||||:.|||:|:|::..:.||:..|::||..||:|..:|::||..|.||:.|..:|.
Human  1421 DQIHTHMRPLLMMLGDYRSLTLNVVNRLTSVTRLFPNSFNDKFCDQMMQHLRKWMEVVVITHKGG 1485

  Fly  1437 ----------------TSPNVNFFASSKGGEYEQKIV-ILIEMFFYISASVKYIEK-LCQLVLKT 1483
                            .||...|..:.:|.| |.||. .:|.:|..|.|:.:.:.| |.::|:||
Human  1486 QRSDGNESISECGRCPLSPFCQFEPAMEGVE-EMKICSAIINLFHLIPAAPQTLVKPLLEVVMKT 1549

  Fly  1484 EKNLMIEASSPYREALIKFLQRFPTETVDLFLTESLMIDPQWNRLFIYLLKHETGVSFRAVIKSS 1548
            |:.::|||.||:||.|||||.|.|::||:||:.|:.:.||||:|:|:..|||:.....|.|: ::
Human  1550 ERAMLIEAGSPFREPLIKFLTRHPSQTVELFMMEATLNDPQWSRMFMSFLKHKDARPLRDVL-AA 1613

  Fly  1549 RYNNLIHYL--------------NTHTEFPEALKYEIQHQAVLIIFTLMESDDQWIPTRQDIVDA 1599
            ..|..|..|              :|.|     ::.::|.||:.||..::::||.|:.::..:|..
Human  1614 NPNRFITLLLPGGAQTAVRPGSPSTST-----MRLDLQFQAIKIISIIVKNDDSWLASQHSLVSQ 1673

  Fly  1600 LKNCW--QNYLSTLSSEDVLCDLW---HLIGKILLHYFSNNTNDIELLFQLLRALCFRFIPDVYF 1659
            |:..|  :|:......|::....|   .|:...||:|...|..|||||||||||...||:.::.|
Human  1674 LRRVWVSENFQERHRKENMAATNWKEPKLLAYCLLNYCKRNYGDIELLFQLLRAFTGRFLCNMTF 1738

  Fly  1660 LRDFLQHTVAQSFTVNWKRNAFFYFVENFNNSFLSEELKAKIITAVIIPCFAVSFDKGEGNKLIG 1724
            |:::::..:.:::::..||..||.||: ||:....:|||||::..::.|.|..||:||||.:|:|
Human  1739 LKEYMEEEIPKNYSIAQKRALFFRFVD-FNDPNFGDELKAKVLQHILNPAFLYSFEKGEGEQLLG 1802

  Fly  1725 APPTPYQEDEKNIVSVFINKVFDPDKQYD--DAVRIALLQLACLLVERASQHIHDGDANNKRQGN 1787
             ||.|..::.::|.||||.||.||:||.|  |::||.|||.|.||||.|..||||   |||.:.:
Human  1803 -PPNPEGDNPESITSVFITKVLDPEKQADMLDSLRIYLLQYATLLVEHAPHHIHD---NNKNRNS 1863

  Fly  1788 KLRRLMTFAWPCLLSKSSVDPTARYHGHLLLSHIIARLAIHKKIVLQVFHSLLKGHALEARSIVK 1852
            ||||||||||||||||:.|||..:|.|||||:||||:.||||||||||||||||.||:|||:||:
Human  1864 KLRRLMTFAWPCLLSKACVDPACKYSGHLLLAHIIAKFAIHKKIVLQVFHSLLKAHAMEARAIVR 1928

  Fly  1853 QALDVLTPAMPLRMEDGNTMLTHWTKKIIVEEGHAMQQLFHILQLIIRHYKVYFPVRHQLVQHLI 1917
            ||:.:||||:|.|||||:.||||||:||||||||.:.||.|||.||::|:|||:||||.||||::
Human  1929 QAMAILTPAVPARMEDGHQMLTHWTRKIIVEEGHTVPQLVHILHLIVQHFKVYYPVRHHLVQHMV 1993

  Fly  1918 NYMQRLGFPPTASIEHKKLAVDLAEVIIKWELHRIKD-----DRETKTDGTEEELIQESSVKRS- 1976
            :.||||||.|:.:||.::|||||:||:|||||.||||     |.:..:.|.....: .||:||.
Human  1994 SAMQRLGFTPSVTIEQRRLAVDLSEVVIKWELQRIKDQQPDSDMDPNSSGEGVNSV-SSSIKRGL 2057

  Fly  1977 GIDLVETRKKSFDIIRETTVQGV------GSHTKP--DDIL-RSIDKSYCDTVLNFLIRLACQVN 2032
            .:|..:      ::.|..|..|.      .|.:.|  |.:| :.|||.:.|||:|||||:|||||
Human  2058 SVDSAQ------EVKRFRTATGAISAVFGRSQSLPGADSLLAKPIDKQHTDTVVNFLIRVACQVN 2116

  Fly  2033 DPQAPILSPGESLSRRCVMLLKMAMRPEIWPQPFDIKLNWLDKVLATVETPHH-NLNNICTGIDF 2096
            |......||||.||||||.|||.|:||::||:. ::||.|.||:|.|||.|:. |..|||||::.
Human  2117 DNTNTAGSPGEVLSRRCVNLLKTALRPDMWPKS-ELKLQWFDKLLMTVEQPNQVNYGNICTGLEV 2180

  Fly  2097 LTFLTTILSPDQLVSIIRPVQRGLSLCIIHQNTRIVRLMHMFLTRIMAIFP--PDTQ---HKHED 2156
            |:||.|:|....::|..:|:|||::.|:...||:::|.:|..|:|:|:|||  |.|.   .|:|:
Human  2181 LSFLLTVLQSPAILSSFKPLQRGIAACMTCGNTKVLRAVHSLLSRLMSIFPTEPSTSSVASKYEE 2245

  Fly  2157 LDLLYTAVSKMIAENLTSYEKSPQPNASSLFGTLMILKACTTNNASYIDRILVQFIRVLNHLTRD 2221
            |:.||.||.|:|.|.||:|||:...|.|.|||||||||:..:||.|||||::..|:|.|..:.|:
Human  2246 LECLYAAVGKVIYEGLTNYEKATNANPSQLFGTLMILKSACSNNPSYIDRLISVFMRSLQKMVRE 2310

  Fly  2222 HINTIGGNTVISQSPDSNALPLELLVLSLELIKNRIFVMSVEIRKLFIGTILVSLIEKSTEVKII 2286
            |:|.    ...|.|.::.:...||::|||||:|.|:.|||:|:||.||..||.||||||.:.||:
Human  2311 HLNP----QAASGSTEATSGTSELVMLSLELVKTRLAVMSMEMRKNFIQAILTSLIEKSPDAKIL 2371

  Fly  2287 KCIIKMLDEWIKTKEPNVMTQVPSIREKSALLVKLMQNVEKKFTDEIELNIQFLEIINFIYRDEI 2351
            :.::|:::||:|...|....|.|::||||.||||:|..:||:|.:::|||.|||:::|::||||.
Human  2372 RAVVKIVEEWVKNNSPMAANQTPTLREKSILLVKMMTYIEKRFPEDLELNAQFLDLVNYVYRDET 2436

  Fly  2352 LKQTELTNKLEGAFLNGLRFQNPNVRSKFFEILDSSMRRRLHDRLLYIICSQAWDTIGSHYWIKQ 2416
            |..:|||.|||.|||:|||...|.:|:||||:.|:||:||:::||||:.|||.|:.:|:|:||||
Human  2437 LSGSELTAKLEPAFLSGLRCAQPLIRAKFFEVFDNSMKRRVYERLLYVTCSQNWEAMGNHFWIKQ 2501

  Fly  2417 CIELLILTANTMMQIQCSNEQFKIPSITSVIPVNSSETQENSFVSFLSSHSESFDIIQTVDDKDD 2481
            |||||:........|..|.:...:||||:||  |.:::.:.:..:.::...:.....:..:.|::
Human  2502 CIELLLAVCEKSTPIGTSCQGAMLPSITNVI--NLADSHDRAAFAMVTHVKQEPRERENSESKEE 2564

  Fly  2482 VYDIDLN---ADR------KEDCQQILPNRRVTLVELVYKQAEFLEANRNIRTDQMLVATSQLCH 2537
            ..:||:.   .|:      ||..::.:.|:   |..|..:..:||:..|.::|..:|.|..||||
Human  2565 DVEIDIELAPGDQTSTPKTKELSEKDIGNQ---LHMLTNRHDKFLDTLREVKTGALLSAFVQLCH 2626

  Fly  2538 IDTQLAQSVWLSMFPRIWSIFTEDQRCNITKELIPFLSSGTNVNQKDCHPSTLNTFVESLTKCAP 2602
            |.|.||:..|:.:|||:|.|.::.|:..:..|:.|||.||::..|:||.||.||.|||::::|.|
Human  2627 ISTTLAEKTWVQLFPRLWKILSDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVP 2691

  Fly  2603 PIYIPPNLLAYLGKSHNLWHRAILVLEDMAVNQ--SMQSKDIDGGENQFSDLDVQQS-----NNI 2660
            ||.|.|.:|.||||:||||.|:.|:||..|..:  |:|.|     ..|.::...|:|     ..|
Human  2692 PIPIRPCVLKYLGKTHNLWFRSTLMLEHQAFEKGLSLQIK-----PKQTTEFYEQESITPPQQEI 2751

  Fly  2661 FDSLSKMYSSMHEEDLWAGLWLKFAHYPETNIAVSYEQMGFFEEAQGAYDLAMTKFKQDLSNGVV 2725
            .|||:::||.:.|||:|||||.|...|.||..|::|||.||||:||.:|:.||.|.|::......
Human  2752 LDSLAELYSLLQEEDMWAGLWQKRCKYSETATAIAYEQHGFFEQAQESYEKAMDKAKKEHERSNA 2816

  Fly  2726 NTYVNSELLLWENHWMRCAKELNQWDILLDYAQTNKDKNMFLILESSWRVPDWNLMKIALAKTEQ 2790
            :..:..|..|||:||:||:||||||:.|.:|.|:....|.:|:||.:|||.:|..||.||.:.|.
Human  2817 SPAIFPEYQLWEDHWIRCSKELNQWEALTEYGQSKGHINPYLVLECAWRVSNWTAMKEALVQVEV 2881

  Fly  2791 CYLKHYGFKINLYKGYLSILHQEERQTGNIERYVEIASSLCIREWRRLPNIVSHIHLPYLQASQQ 2855
            ...|...:|:|:|:|||:|.|.||:|...|||.||:||||.||||||||::|||:|.|.|||:||
Human  2882 SCPKEMAWKVNMYRGYLAICHPEEQQLSFIERLVEMASSLAIREWRRLPHVVSHVHTPLLQAAQQ 2946

  Fly  2856 IMELHEASQIHQGLAQS---RNNSLHDMKAIVKTWRNRLPIISDDLSHWSDIFTWRQHHYQIITQ 2917
            |:||.||:||:.||..:   |||||||||.:||||||||||:||||||||.||.|||||||.|..
Human  2947 IIELQEAAQINAGLQPTNLGRNNSLHDMKTVVKTWRNRLPIVSDDLSHWSSIFMWRQHHYQAIVT 3011

  Fly  2918 HLEQQS----DQGSTMLGVHASAQAIISFGKIARKHNLTGVCQETLSRIYTIPSVPIVDCFQKIR 2978
            ..|..|    ...:.||||||||.|||.:||||||..|..|..:.||||:|||:|||||||||||
Human  3012 AYENSSQHDPSSNNAMLGVHASASAIIQYGKIARKQGLVNVALDILSRIHTIPTVPIVDCFQKIR 3076

  Fly  2979 QQVKCYLQMPSTSGKNEINEALEVIESTNLKYFTGEMNAEFYALKGLLLAQIGRSEEAGKSFSVA 3043
            ||||||||:....||||..:.|||||||||||||.||.||||||||:.||||.:||||.|:||.|
Human  3077 QQVKCYLQLAGVMGKNECMQGLEVIESTNLKYFTKEMTAEFYALKGMFLAQINKSEEANKAFSAA 3141

  Fly  3044 AQLHDGLTKAWAMWGDYMEQIFLKERKITLAVDALICYLQASRNQIESKTRKYIAKVLWFLSYDN 3108
            .|:||.|.|||||||||:|.||:|||::.|.|.|:.|||.|.|:|.|||:|||:|||||.||:|:
Human  3142 VQMHDVLVKAWAMWGDYLENIFVKERQLHLGVSAITCYLHACRHQNESKSRKYLAKVLWLLSFDD 3206

  Fly  3109 NTKILISTLEKHVAGIPPSYWLPWIPQLLCCLEQFEGDVILNLLSQIGRLYPQAVYFPIRTLYLT 3173
            :...|...::|:..|:||..||.||||||.||...||.::|||:||:||:|||||||||||||||
Human  3207 DKNTLADAVDKYCIGVPPIQWLAWIPQLLTCLVGSEGKLLLNLISQVGRVYPQAVYFPIRTLYLT 3271

  Fly  3174 LKIEQREKHKT-AEQAVKSSCSNIDGTTLSFGRGASHGNIPSINPIKATPPMWRCSKVMQLQREV 3237
            |||||||::|: :.|...||..|           .|| :.....||:||.||||||::|.:|||:
Human  3272 LKIEQRERYKSDSGQQQPSSVGN-----------QSH-SASDPGPIRATAPMWRCSRIMHMQREL 3324

  Fly  3238 HPTILSSLEGIVDQMVWFRESWTEEVLRQLRQGLIKCYAIAFEKRDTVQHSTITPHTLHFVKKLG 3302
            |||:||||||||||||||||:|.|||||||:|||.|||::||||...|..:.||||||:|||||.
Human  3325 HPTLLSSLEGIVDQMVWFRENWHEEVLRQLQQGLAKCYSVAFEKSGAVSDAKITPHTLNFVKKLV 3389

  Fly  3303 STFGIGIENVPGSVTSSISNSAASESLARRAQVTFQDPVFQKMKEQFTNDFDFSKPGAMKLHNLI 3367
            ||||:|:|||  |..|::.:||||||||||||.|.|||||||:|.|||.|||||.||:|||||||
Human  3390 STFGVGLENV--SNVSTMFSSAASESLARRAQATAQDPVFQKLKGQFTTDFDFSVPGSMKLHNLI 3452

  Fly  3368 SKLKTWIKVLETKVKKLPTSFLIEDKCRFLSNFSQKTAEVELPGELLIPLSSHYYVRIARFMPRV 3432
            ||||.|||:||.|.|:||..||||:|||||||||.:|||||:|||.|:|..:|||::||||||||
Human  3453 SKLKKWIKILEAKTKQLPKFFLIEEKCRFLSNFSAQTAEVEIPGEFLMPKPTHYYIKIARFMPRV 3517

  Fly  3433 EIVQKNNTAARRLYIRGTNGKIYPYLVVLDSGLGDARREERVLQLKRMLNYYLEKQKETSRRFLN 3497
            |||||:|||||||||||.|||||||||:.|:.|.::|||||||||.|:||..|||:|||::|.|.
Human  3518 EIVQKHNTAARRLYIRGHNGKIYPYLVMNDACLTESRREERVLQLLRLLNPCLEKRKETTKRHLF 3582

  Fly  3498 ITVPRVVPISPQMRLAEDNPNSISLLKIFKKCCQSMQVDYDMPIVKYYDRLSEVQARGTPTTHTL 3562
            .||||||.:||||||.||||:|:||::|:|:.|....:::|.||.:|||||:.||||||..:|.:
Human  3583 FTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQRCAKKGIEHDNPISRYYDRLATVQARGTQASHQV 3647

  Fly  3563 LREIFSEIQWTMVPKTLLKHWALKTFLAATDFWHFRKMLTLQLALAFLCEHALNLTRLNADMMYL 3627
            ||:|..|:|..|||:::||.|||.||..|||:|.||||.|:||||....|..|:|.|||.:|:.:
Human  3648 LRDILKEVQSNMVPRSMLKEWALHTFPNATDYWTFRKMFTIQLALIGFAEFVLHLNRLNPEMLQI 3712

  Fly  3628 HQDSGLMNISYFKFDVNDDKCQLNQHRPVPFRLTPNVGEFITHFGITGPLSAAIVATARCFIQPN 3692
            .||:|.:|::||:||:||....|:.:||||||||||:.||:|..|::|||:|:::|.||||.|||
Human  3713 AQDTGKLNVAYFRFDINDATGDLDANRPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPN 3777

  Fly  3693 YKLSSILQTILRDEIIALQKKGFRECK--LIEGSEDRYSDGNCMEHSVNIVNSAVDIIMTRFNKI 3755
            :|:..||:|:|||||||..||...:..  |....:....|.   :..|::|..||..||||.:.:
Human  3778 FKVDGILKTVLRDEIIAWHKKTQEDTSSPLSAAGQPENMDS---QQLVSLVQKAVTAIMTRLHNL 3839

  Fly  3756 SYFDSIENKKISVLVQSATNIDNLCRMDPAWHPWL 3790
            :.|:..|: |::.||.:|.::||||||||||||||
Human  3840 AQFEGGES-KVNTLVAAANSLDNLCRMDPAWHPWL 3873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nipped-A	NP_001097192.2	FRB_dom	<2568..3790	CDD:331513	726/1238 (59%)
		FAT	2767..3102	CDD:308074	220/341 (65%)
		PIKK_TRRAP	3425..3712	CDD:270707	175/286 (61%)
TRRAP	NP_001362453.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..541		7/49 (14%)
		Interaction with TP53. /evidence=ECO:0000269\|PubMed:12138177	2017..2395		173/389 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2030..2051		3/21 (14%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	2054..2069		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2550..2585		4/34 (12%)
		TEL1	<2552..3873	CDD:227365	756/1346 (56%)
		FAT	2868..3200	CDD:367004	214/331 (65%)
		PIKK_TRRAP	3510..3797	CDD:270707	175/286 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159482
Domainoid	1	1.000	1991	1.000	Domainoid score	I1
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39246
Inparanoid	1	1.050	3815	1.000	Inparanoid score	I8
Isobase	1	0.950	-	0.861654	Normalized mean entropy	S3127
OMA	1	1.010	-	-		QHG55308
OrthoDB	1	1.010	-	-		D4534at33208
OrthoFinder	1	1.000	-	-		FOG0003313
OrthoInspector	1	1.000	-	-		oto89127
orthoMCL	1	0.900	-	-		OOG6_101815
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2817
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.760