Protein Alignment Nipped-A and Tor

DIOPT Version :9

• Sequence 1: NP_001097192.2
• Gene: Nipped-A / 35483
• FlyBaseID: FBgn0053554
• Length: 3790
• Species: Drosophila melanogaster
• Sequence 2: NP_001260427.1
• Gene: Tor / 47396
• FlyBaseID: FBgn0021796
• Length: 2471
• Species: Drosophila melanogaster
• Alignment Length: 3039
• Identity: 545/3039 - (17%)
• Similarity: 1028/3039 - (33%)
• Gaps: 939/3039 - (30%)

  Fly  1121 MSLRALFQNLFNFLKAFMFVLMDLEGDVSNGAIEITKSYMKSMLEICLTPINECYKNIDLKDLQA 1185
            ||..::.|...|.||:       ...:|.|.|.:....|:|:                :|:::..
  Fly     1 MSTTSVVQQFVNGLKS-------RNRNVQNKATQDLLFYVKT----------------ELREMSQ 42

  Fly  1186 KATYEVIHELVRHI-TSPN-TIVREE---SMVLLKHIGTIQSKTVSEVMDPHKDVLADIIPPKKH 1245
            :...:...|...|| |..| |.:.|:   ::.:...|....|.|..:.:.|:.:.|.|::.....
  Fly    43 EELAQFFDEFDHHIFTMVNATDINEKKGGALAMKCLINCEGSLTARKGISPYLNRLRDLLLINDV 107

  Fly  1246 LLRHQPANAQIGLMDGNTFCTTLEPRLFTIDLTNTYHKLFFHELLTLSEAEDATLAKLDCYKNVP 1310
            .:....|.:.:.|.:   ..|:.....|..|:...:      |:|.....|         |:...
  Fly   108 SVMEIAARSLVKLAN---MPTSKGADSFDFDIKKAF------EVLRGERQE---------YRRHS 154

  Fly  1311 NLIPLRTSALRALAACHYISDIGYKEKIINIIFKVMESDKSELQTTAFHCMKHFITGVTLEKEKV 1375
            .:..||..|: ||....|...:.:.|.|.|.||    ..|..::.:|...::..:. ||.::|..
  Fly   155 AVFILRELAI-ALPTYFYQHILTFFEVIFNAIF----DPKPAIRESAGEALRAALI-VTAQREST 213

  Fly  1376 QSAMRPLLLKL-GDHRNLSIPA-----------------------------------IKRLSYFT 1404
            :.:..|...:: .|..|.|..|                                   .:|.:...
  Fly   214 KQSSEPQWYRICYDEANGSFNADLGSSKDQKGVTRDDRIHGGLVVFNELFRCANATWERRYTSLK 278

  Fly  1405 QIFPQMFNEKLSE---------QILQHCSKIMEIFVSEYKSTSPNVNFFASSKG----------- 1449
            .:||:..:.|..|         |:.....::...|:.:..||..::......||
  Fly   279 TLFPKTQHNKFLEASSSSSMGSQLNTLVPRLKVPFIDKLGSTQTHLGEGEHHKGVAKFASQHNVL 343

  Fly  1450 -GEYEQKIVILIEMFFYISASVKYIEKLCQLVL--KTEKNLMIEASSPY-REALIKFLQRFPTET 1510
             ..|.|:|:            .::...:|..||  :|.|       ||| ::||::.|.|.....
  Fly   344 ESAYAQEIL------------QEHYTSICDNVLEQRTSK-------SPYVQQALLQILPRLAAFN 389

  Fly  1511 VDLFLTE----------SLMIDPQWNRLFIYLLKHETGVSFRAVIKSSRYNNLIHYLNTHTEFPE 1565
            ..:|:.:          .::...:.:|...|:......|:.::.|:       :|..:..|....
  Fly   390 RAVFVEKYLQTCVSHLMQILRGKEKDRTVAYITIGYMAVAVQSAIE-------VHLSSIMTSVKV 447

  Fly  1566 AL-------KYEIQ-HQAVLIIFTLMESDDQWIPTRQDIVDALKNCW-QNYLSTLSSEDVLCDLW 1621
            ||       |.::. ..||....||:..     ..:.:|.|.:|:.. |.:.:.||....:|
  Fly   448 ALPSKDLTSKRKVPVDPAVFACITLLAH-----AVKSEIADDVKDILEQMFYTGLSPALTVC--- 504

  Fly  1622 HLIGKILLHYFSNNTNDIE---------LLFQLL----RALCFRFIPDVYFLRDFLQH----TVA 1669
                   |...|.|...::         :|.|:|    ..|.:..:|.:......:|:    |..
  Fly   505 -------LRELSENVPQLKSAITEGLIGILSQVLMNKAAILPYTALPTIAIDGSLMQNGDGATTV 562

  Fly  1670 QSF----TVNWKRNAFFYFVENFNNSFLSEELKAKIITAV-----IIPCFAVSFDKGEGNKLIGA 1725
            .:.    |.|::......||:...:.|:..|.:...:.||     ::.....|.:..|.:|.:..
  Fly   563 LALKTLGTFNFEEQNMLDFVQRCADYFIVHEQQEIRLEAVQTCTRLLKLAVQSSESMENSKTLSD 627

  Fly  1726 PPTPYQED-----------------EKNIVSVFINKVFDPDK-------QYDDAVRIALL----- 1761
            ..:...|.                 .:::...|..|:..|:.       .:|:...|..|
  Fly   628 TVSHVIERLLMVAITDMDCNVRIRILRSLDETFDGKLAQPESLNSLFITLHDEIFEIRELAMVTI 692

  Fly  1762 -------------QLACLLVERASQHIHDGDANNKRQGNKLRRLMTFAWPCLLSKSSVDPTARYH 1813
                         :|...::|..:...:.|.:.||.|..|:...:..:.|.|:| |.::|
  Fly   693 GRLSSINPAYVMPKLRTTMIELITDLKYSGMSRNKEQSAKMLDHLVISTPRLIS-SYMNP----- 751

  Fly  1814 GHLLLSHIIARLAIHKK-----IVLQVFHSL-----LKGHALEARSIVKQALDVLTPAMPLRMED 1868
               :|..::.:|  |:.     ::|.|..::     :.|.:.|........|.:|...:......
  Fly   752 ---ILKALVPKL--HEPESNPGVILNVLRTIGDLAEVNGGSDEMELWADDLLSILLEMLGDAGSP 811

  Fly  1869 GNTMLTHWTKKIIVEEGHAMQQLFHILQLIIRHYKVYFPVRHQLVQHLINYMQRLGFPPTASIEH 1933
            ....:..||          :.||......::..|..| ||   |:..|||:::
  Fly   812 DKRGVALWT----------LGQLISATGRVVTPYHKY-PV---LIDILINFLK------------ 850

  Fly  1934 KKLAVDLAEVIIKWELHRIKDDRETKTDGTEEELIQESSVKRSGIDLVETRKKSFDIIRETTVQG 1998
                                         ||:        :||              ||..|::.
  Fly   851 -----------------------------TEQ--------RRS--------------IRRETIRV 864

  Fly  1999 VGSHTKPDDILRSIDKSYCDTVL-NFLIRLA-CQVNDPQAPILSPGESLSRRCVMLLKMA-MRPE 2060
            :|.....|.....::|...|:.. |.||..: .:|::.|.  :|..|       :|:.|. ...|
  Fly   865 LGLLGAMDPYKHKMNKGLIDSQKDNVLIAYSDGKVDESQD--ISTAE-------LLVNMGNALDE 920

  Fly  2061 IWPQPFDIKLNWLDKVL--ATVETPHHNLNNICT------GIDFLTFLTTILSPDQLVSIIRPVQ 2117
            .:|.   :.:..|.::|  .|:.|.|.::....|      ||..:.:|..:|  ..|:..:|...
  Fly   921 YYPA---VAIAALMRILRDPTLSTRHTSVVQAVTFIFQSLGIKCVPYLAQVL--PNLLDNVRTAD 980

  Fly  2118 RGLSLCIIHQNTRIVRLMHMFLTRIMA-IFPPDTQHKHEDLDLLYTAVSKMIAENLTSYEKSPQP 2181
            ..|...:..|...:|..:.:.:...|. ||                   |:|.|..|.  .:|..
  Fly   981 NNLREFLFQQLAILVAFVKLHIISYMGDIF-------------------KLIKEFWTI--NTPLQ 1024

  Fly  2182 NA-SSLFGTLMILKACTTNNASYIDRILVQFIRVLNH-------LTRDHINTIG--GNTVISQSP 2236
            |. .:|...:.:...|...:  |:..::.|.:|||.|       :||..:..:.  |:|:....|
  Fly  1025 NTLINLIEQIAVALGCEFRD--YLAELIPQILRVLQHDNSKDRMVTRRLLQALQKFGSTLGYYLP 1087

  Fly  2237 ----------DSNALPLELLVLSLELIKNRIFVMSVEIRKLFIGTILVSLIEKSTEVKIIKCIIK 2291
                      ||..:|.::.:::||.|.|                :...|.......:||..:::
  Fly  1088 LILPPIVKLFDSPYVPQQVSMVALETINN----------------LACQLDFTDFSSRIIHPLVR 1136

  Fly  2292 MLDEWIKTKEPNVMTQVPSIREKSALLVKLMQNVEKKFTDEIELNIQFLEIINFIYRDEILKQTE 2356
            :||            ..|.:|:::...::.:..         :|..::|..:..:.|.
  Fly  1137 VLD------------AEPELRDQAMTTLRSLAK---------QLGKKYLVFVPMVQRT------- 1173

  Fly  2357 LTNKLEGAFLNGLRFQNPNVRSKFFEILDSSMRRRLHDRLLYIICSQAWDTIGSHYWIKQCIELL 2421
                     ||..|..:|.     :|.|.|.::.          ||...|:.|:.
  Fly  1174 ---------LNKHRIVDPE-----YEELLSKIKS----------CSTLADSYGAG---------- 1204

  Fly  2422 ILTANTMMQIQCSNEQFKIPSITSVIPVNSSETQENSFVSFLSSHSESFDIIQTVDDKDDVYDID 2486
                    :.:....:||               ....||:..:|::::..:  |.::....:.:.
  Fly  1205 --------ESELRPSRFK---------------NNEPFVTDRNSNNKNLQV--TTNELRTAWQVT 1244

  Fly  2487 LNADRKEDCQQILPNRRVTLVELVYKQAEFLEANRNIRTDQMLVATSQLCHIDTQLAQSVWLSMF 2551
            .... |:|..:.|  :|:::..|....:..|.|.|::..:           .|| |.:.::.:.|
  Fly  1245 RRVS-KDDWVEWL--KRLSIGLLKESPSHALRACRSLAQE-----------YDT-LLRDLFNAAF 1294

  Fly  2552 PRIWSIFTEDQRCNITKELIPFLSSGTNVNQKDCHPSTLNTFVESLTKC-APPIYIPPNLLAYLG 2615
            ...|:..:.|.:..:|:.||..|    .|........|:....|.:..| ..||.|...||....
  Fly  1295 ISCWTELSPDLKNELTQSLIQAL----QVTDMPEITQTILNLAEFMEHCDRDPIPIETKLLGTRA 1355

  Fly  2616 KSHNLWHRAILVLEDMAVNQSMQSKDIDGGENQFSDLDVQQSNNIFDSLSKMYSSMHEEDLWAGL 2680
            .:...:.:|:...|:                    :..:::.:.:|:||..:.:.:.:.:...||
  Fly  1356 MACRAYAKALRYKEE--------------------EFLLREDSQVFESLILINNKLQQREAAEGL 1400

  Fly  2681 WLKFAHYPETNIAVSYEQMGFFEEAQGAYDLAMTKFKQDLSNGVVNTYVNSELLLWENHWMRCAK 2745
            ..::     .|.|......|.:.|....:|.|:..::::|...      :|:|.....| |||.:
  Fly  1401 LTRY-----RNAANELNVQGRWYEKLHNWDEALEHYERNLKTD------SSDLEARLGH-MRCLE 1453

  Fly  2746 ELNQWDILL--------DYAQTNKDKNMFLILESSWRVPDWNLMK-----IALAKTEQCYLKHYG 2797
            .|..|..|.        ::....|.:...|...::|.:.||..|:     |.....:..|
  Fly  1454 ALGDWSELSNVTKHEWENFGTEAKSRAGPLAAVAAWGLQDWEAMREYVRCIPEDTQDGSY----- 1513

  Fly  2798 FKINLYKGYLSILHQEERQTGNIERYVEIASSLCIREWRRLPNIVSHIHLPYLQA------SQQI 2856
                 |:..|:: |.::.:|.  :|.::....|...|      :.|.....|.:|      .|.:
  Fly  1514 -----YRAVLAV-HHDDFETA--QRLIDETRDLLDTE------LTSMAGESYERAYGAMVCVQML 1564

  Fly  2857 MELHEASQIHQGLAQSRNNSLHDM--------KAIVKTWRNRLPIISDDLSHWSDIFTWRQHHYQ 2913
            .||.|.  |...|...|...|..|        :.:|:.||..:.:.|..:....||.||.:  |.
  Fly  1565 AELEEV--IQYKLIPERREPLKTMWWKRLQGGQRLVEDWRRIIQVHSLVVKPHEDIHTWLK--YA 1625

  Fly  2914 IITQ-----HLEQQSDQGSTMLGVHA-----------SAQAIISFGKIARKHNLTGVCQETLSRI 2962
            .:.:     ||..::  ...:||...           ..|...::.|....:|......|.|:..
  Fly  1626 SLCRKSGSLHLSHKT--LVMLLGTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQLQEAYEQLTHF 1688

  Fly  2963 YTIPSVPIVDCF--QKIRQQ-----VKCYLQMPSTSGKNEINEALEVIESTNLKYFTGEMNAEFY 3020
            .:..|..: .|.  :.::||     .:|||:|  .:.:|::.:::..                 .
  Fly  1689 VSTYSQEL-SCLPPEALKQQDQRLMARCYLRM--ATWQNKLQDSIRP-----------------D 1733

  Fly  3021 ALKGLLLAQIGRSEEAGKSFSVAAQLHDGLTKAWAMWGDYMEQIFLKERKITL------------ 3073
            |::|.|           :.|..|........|||.:|. ||....::.:|..|
  Fly  1734 AIQGAL-----------ECFEKATSYDPNWYKAWHLWA-YMNFKVVQAQKSALDKQQPPGASMGM 1786

  Fly  3074 ----------------AVDALICYLQA----SRNQIESKTRKYIAKVLWFLSYDNNTKI---LIS 3115
                            ||.|:..:.::    ..|.::...|   ...||| .|.|:.::   |:|
  Fly  1787 TMGSGLDSDLMIIQRYAVPAVQGFFRSISLIKGNSLQDTLR---LLTLWF-DYGNHAEVYEALLS 1847

  Fly  3116 TLEKHVAGIPPSYWLPWIPQLLCCLE---QFEGDVILNLLSQIGRLYPQAVYFPIRTLYLTLKIE 3177
            .::.    |..:.||..||||:..::   |..|.:|..||..||:.:|||:.:|:
  Fly  1848 GMKL----IEINTWLQVIPQLIARIDTHRQLVGQLIHQLLMDIGKNHPQALVYPL---------- 1898

  Fly  3178 QREKHKTAEQAVKSSCSNIDGTTLSFGRGASHGNIPSINPIKATPPMWRCSKVMQLQREVHPTIL 3242
                      .|.|..:::.....:|                         |::...|:..||::
  Fly  1899 ----------TVASKSASLARRNAAF-------------------------KILDSMRKHSPTLV 1928

  Fly  3243 SSL----EGIVDQMVWFRESWTEEVLRQLRQGLIKCYAIAFEKRDT--------VQHSTIT--PH 3293
            ...    |.::...:.:.|.|.|        ||.:...:.|..|:.        ..|:.:.  |.
  Fly  1929 EQAVMCSEELIRVAILWHEQWHE--------GLEEASRLYFGDRNVKGMFEILEPLHAMLERGPQ 1985

  Fly  3294 TLHFVKKLGSTFGIGIENVPGSVTSS-ISNSAASESLARRAQVTFQDPVFQKMKEQFTNDFDFSK 3357
            ||   |:...:...|.|.......|. ...||....|.|...:.:.  ||||:..|      ..:
  Fly  1986 TL---KETSFSQAYGRELTEAYEWSQRYKTSAVVMDLDRAWDIYYH--VFQKISRQ------LPQ 2039

  Fly  3358 PGAMKLHNLISKLKTWIKVLETKVKKLPTSFLIEDKCRFLSNFSQKTAEVELPGELLIPLSSHYY 3422
            ..:::|..:..||.| .|.||..|   |.|:                    .||:.||
  Fly  2040 LTSLELPYVSPKLMT-CKDLELAV---PGSY--------------------NPGQELI------- 2073

  Fly  3423 VRIARFMPRVEIVQKN------NTAARRLYIRGTNGKIYPYLVVLDSGLGDARREERVLQLKRML 3481
                    |:.|::.|      ....|:|.|||:|||.|.||:   .|..|.|::|||:||..::
  Fly  2074 --------RISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLL---KGHEDLRQDERVMQLFSLV 2127

  Fly  3482 NYYLEKQKETSRRFLNITVPRVVPISPQMRLAEDNPNSISLLKIFKKCCQSMQV----------- 3535
            |..|....:|.||.|.|....|:|:|....|....|:..:|..:.:......:|
  Fly  2128 NTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLN 2192

  Fly  3536 ---DYD----MPIVKYYDR-LSEVQARGTPTTHTLLREIFSEIQWTMVPKTLLKHWALKTFLAAT 3592
               |||    |..|:.::. |.:.|.           :..:::.|...|              ::
  Fly  2193 FAPDYDHLTLMQKVEVFEHALGQTQG-----------DDLAKLLWLKSP--------------SS 2232

  Fly  3593 DFWHFRK-MLTLQLALAFLCEHALNLTRLNADMMYLHQDSG-LMNISY---FKFDVNDDKCQLNQ 3652
            :.|..|: ..|..||:..:..:.|.|...:...:.|.:.|| :::|.:   |:..:..:|..
  Fly  2233 ELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKFP--- 2294

  Fly  3653 HRPVPFRLTPNVGEFITHFGITGPLSAAIVATARCFIQPNYKLSSILQTILRD-----EIIALQK 3712
             ..:|||||..:.:.:...||.|.......:......:....|.::|:..:.|     .::.:.|
  Fly  2295 -EKIPFRLTRMLIKAMEVTGIEGTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDK 2358

  Fly  3713 KGFREC--------KLIEGSEDRYSDGNCMEHSV-------------------NI---VNSAVDI 3747
            ||....        :...|.:|..|  |.:|.|:                   |:   .||....
  Fly  2359 KGNDAVAGAGAPGGRGGSGMQDSLS--NSVEDSLPMAKSKPYDPTLQQGGLHNNVADETNSKASQ 2421

  Fly  3748 IMTRFN-KISYFD-----SI-ENKKISVLVQSATNIDNLCRMDPAWHPW 3789
            ::.|.. |::..|     |: |..::.:|:|.|||.:|||:....|.|:
  Fly  2422 VIKRVKCKLTGTDFQTEKSVNEQSQVELLIQQATNNENLCQCYIGWCPF 2470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nipped-A	NP_001097192.2	FRB_dom	<2568..3790	CDD:331513	274/1398 (20%)
		FAT	2767..3102	CDD:308074	71/408 (17%)
		PIKK_TRRAP	3425..3712	CDD:270707	69/321 (21%)
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	484/2685 (18%)
		HEAT repeat	632..658	CDD:293787	1/25 (4%)
		HEAT repeat	668..698	CDD:293787	3/29 (10%)
		HEAT repeat	706..736	CDD:293787	7/29 (24%)
		HEAT repeat	749..780	CDD:293787	6/40 (15%)
		HEAT repeat	798..823	CDD:293787	4/34 (12%)
		DUF3385	831..999	CDD:288698	45/248 (18%)
		HEAT repeat	841..870	CDD:293787	12/91 (13%)
		HEAT repeat	880..917	CDD:293787	11/45 (24%)
		HEAT repeat	925..954	CDD:293787	6/28 (21%)
		Rapamycin_bind	1937..2034	CDD:285924	23/109 (21%)
		PIKKc_TOR	2075..2353	CDD:270713	68/309 (22%)
		FATC	2440..2471	CDD:280430	12/31 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464447
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940