DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nipped-A and tefu

DIOPT Version :10

Sequence 1:NP_001097192.2 Gene:Nipped-A / 35483 FlyBaseID:FBgn0053554 Length:3790 Species:Drosophila melanogaster
Sequence 2:NP_001036712.1 Gene:tefu / 41839 FlyBaseID:FBgn0045035 Length:2767 Species:Drosophila melanogaster


Alignment Length:3504 Identity:638/3504 - (18%)
Similarity:1182/3504 - (33%) Gaps:1136/3504 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   642 FLANPTTSPLFATVLVEYLLNKMEEMGSNLERSNLYLRLFKLVFGSVSLFPVENEQMLRPHLHKI 706
            ||:.  ||.:..|.:.|.....:.:...|||..|  .::||.:.|...|:  :|.      |.||
  Fly    45 FLSK--TSDISWTTIFEASKEALFKQAGNLEDVN--EKVFKTLAGKNYLY--DNV------LEKI 97

  Fly   707 VNRSMELALISEEPYN-YFLLLRALFRSIGGG-SHDLLYQEFLPLLPNLLEGLNRLQSGFHK--Q 767
            ...::|..  |:...| :||...::|.:...| ...::.:.|...:.:|||      .|.:.  .
  Fly    98 TQFNLEAG--SQTSGNGHFLAKTSIFSAFEDGIKMRVVVKYFGDRILSLLE------KGIYSSVS 154

  Fly   768 HMRDLFVELCLTVPVRLSSLLPYLPML---MDPLVSALNGSPTLISQGLRTLELCVDNLQPDFLY 829
            ::|||.:.       ..|.:|.||..|   ||.::..     .::....||:.|..|.:|.    
  Fly   155 YVRDLKIN-------EYSRILSYLFELNVDMDEVLRT-----RILKCITRTVSLAKDRVQL---- 203

  Fly   830 DHIQPVRAALMQALWKTLRNQDNAALVAFRVLGKFGGGNRK--------MMVEPQALSYIINDKP 886
             |:.         |.:.|....:.||.||        |.||        :.....|::|  |.:.
  Fly   204 -HVD---------LVEYLPELSSFALSAF--------GARKTEIVRVYLIFASELAVNY--NHQL 248

  Fly   887 TI---SIVTYFQEYETPIDFPVDEAIKSAFRALGSNSTDQFYRRQSWEVIRCFLAAFISLDDEKH 948
            .:   .|:....||.....|..|  .::.|....|.|....|       ::..:..|.:|....|
  Fly   249 NVHMQEILPKLCEYHDEDAFRDD--TRNLFFQCVSKSLHSMY-------LKMDMCDFNTLGVPVH 304

  Fly   949 -----MLLKLFTHVDFVENKIMNWSTFQHKAGNETVRETHQTALIGMLVASATKDLRDSVCPVMA 1008
                 .||:|.|.|: ||.:..:|:..::             ||:.....|              
  Fly   305 EKWPQTLLRLKTIVN-VEIRKNSWARCKN-------------ALLSNNKFS-------------- 341

  Fly  1009 AVVRHYTMVAIAQQAGPFPQKGYQATHGIDPMILIDALASCM---------------GHEEKELC 1058
                                         ||.|.:.|||..:               |...|::.
  Fly   342 -----------------------------DPFIKMSALAMYIVLWHLETKKADENGEGDAPKKIP 377

  Fly  1059 KPGIACMGIILDTATNIMGNKDRACKLPIIQYLAEKMVSLCYDRPWYSKVGGCQAIQFLCKHMSL 1123
            ||                     |.|:..|..|.:|..: .::..|         :....:.:.|
  Fly   378 KP---------------------ADKMETIFSLIDKKEN-TFNDVW---------LAIFTEILQL 411

  Fly  1124 RALFQNLFNFLKAFMFV--LMDLEGDVSNGAIEITKSYMKSMLEIC----LTPINECYKNIDLK- 1181
            .::..|:.|:..|...|  :|.:.|:..|         ::: |.:|    ||...|...:..:: 
  Fly   412 SSVILNVANYQMALTTVAEIMQMYGNAKN---------LRN-LRLCLAHLLTKEQELLHSKSIRE 466

  Fly  1182 DLQAKATYEVIHELVRHITSPNTIVREESMV---LLKH-------IGTIQSKTVSEVMDPHKDVL 1236
            |...:...::.::|:...|:.:..::|:.:|   |::|       ..|:.:..:|..|....:.|
  Fly   467 DFLGELWSQMANQLISETTTNSEEIKEKQLVLQMLIRHNKLNQKLSSTLLNNIISNEMLKRNECL 531

  Fly  1237 ADIIPPKKHLLRH------QPANAQI--------GLMDG----------NTFCTTLEPRLFTIDL 1277
            |.|    :.:..|      ..|:|.:        |..|.          ::....|:...|.|.:
  Fly   532 ATI----REIFIHADKCGQDKASADLEPIIAWAYGSADRFIAAQMIHNIDSIDAQLQADTFAISI 592

  Fly  1278 TNTYHKLFFHELLTLSEAEDATLAKLDCYKNVPNLIPLRTSALRALAACHYISDIGYKEKII--- 1339
            .|.   |...:|..:|::|              :::|   |..|.|.|      ..|.|::|   
  Fly   593 INF---LDVQQLRQISQSE--------------HIVP---STERNLLA------YKYNEQLICFD 631

  Fly  1340 -------NIIFKVMESDKSELQTTAFHCMKHFITGVTLEKEKVQSAMRPL--LLKLGDHRNLSIP 1395
                   ..|..:....|:.|..:.:.|:...:.....::.|..:.::.|  ||||       |.
  Fly   632 KDYATPFESITHIQSETKNCLIQSNYDCLMRGLNFEIAKENKPAAIIKNLNSLLKL-------IC 689

  Fly  1396 AIKRLSYFTQIFPQMFNEKLSEQILQHCSKIMEIFVSEYKSTSPNVNFFASSKGGEYEQK--IVI 1458
            .::||.:: ::|        .......|..|..|.:  |.|   ::.|...:.|.|...|  :..
  Fly   690 TMERLLHY-KVF--------DADTYTGCPLIKRIGL--YLS---HIEFQLKANGAEILDKSDLPE 740

  Fly  1459 LIEMFFYISASVKYIEKLCQLVLKTEKNLMIEASSPYREALIKFLQRFPTETVDLFLTESLMIDP 1523
            ::.:..|:..           |.:|  ||:          |:.:|:|.|.|.:..|:..:|.   
  Fly   741 ILRLEIYVLD-----------VFRT--NLV----------LLDYLERQPIEMLVEFVGAALK--- 779

  Fly  1524 QWNRLFIYLLKHETGVSFRAVIKSSRYNNLIHYL---NTHTEFPEALKYEIQ-----H-QAVLII 1579
                  ::.::.|..|.......:....|::..|   |:|.:  ||.::.::     | |.|||:
  Fly   780 ------LHSMQRERSVDADHGTITRLCLNILAGLCAYNSHRD--EAFEHIVKVTMRWHPQDVLIV 836

  Fly  1580 F-------TLMESDDQWIPTRQDIVDALKNCWQ-------------NYLSTL-----SSEDVLCD 1619
            .       |:.|:...|      :|..||..:|             .::.|:     ..|:.|.|
  Fly   837 TKMLCSCQTISEASSSW------LVSKLKTLFQQHHQDAELMDKVVQHMPTIFYFVRHKENHLDD 895

  Fly  1620 LWHLIGKIL-----LHYFSNNTNDIELLFQLLRALCFRFIPDVYFLRDFLQHTVAQSFTVNWKRN 1679
            :...:..:|     ..|.||.|..|.....|:...|    ||:|.|         ::|.|..|..
  Fly   896 MLMALNSLLRIAIKKSYTSNLTAKIVRCVGLIAQRC----PDIYLL---------ENFAVICKST 947

  Fly  1680 AFFYFVENFNNSFLSEELKAKIIT-AVIIPCFAVSFDKGEGNKLIGAPPTPYQEDEKNIVSVFIN 1743
            |.|..:......|      |.:.| .:::....|:.|      .||...|.:...::...|:...
  Fly   948 AKFITMPTLEVRF------ATLFTFTILLESNCVTSD------AIGHSRTHWDFCQELYESIEFK 1000

  Fly  1744 KVFDPDKQYDDAVR---IALLQLACLLVERASQHIHDGDANNKRQGNKLRRLMTFAWPCLLSKSS 1805
            |:   ....:||::   ..::|:...:..|:|.|          |...|:.              
  Fly  1001 KL---TYNNEDAIQNSNALIVQMLIAIFLRSSFH----------QEIALKE-------------- 1038

  Fly  1806 VDPTARYHGHLLLSH-IIARLAIHKKIVLQVFHSLLKGHALEARSIVKQALDVLTPAMPLRMEDG 1869
                       ||.| .:.||...:.|.||   |:...|....|.:::....:|           
  Fly  1039 -----------LLHHCALRRLTEREFISLQ---SMSSCHRQTVRDLIRPFAAIL----------- 1078

  Fly  1870 NTMLTHWTKKIIVEEGHAMQQLFHILQLIIRHYKVYFPVRHQLVQHLINYMQRLGFPPTASIEHK 1934
               |.||:.|                    |.....||       :.:.|..:..|..|.:    
  Fly  1079 ---LHHWSSK--------------------RWPISKFP-------YFLCYSTKSEFRKTHA---- 1109

  Fly  1935 KLAVDLAEVIIKWELHRIKDDRETKTDGTEEELIQESSVKRSGIDLVETRKKSFDIIRETTV-QG 1998
                  :|::....|:...:|.|..:....|||         .:.::    .||.:|:.::. :.
  Fly  1110 ------SEIMAYTFLYGKTEDIERCSKSISEEL---------ALPIL----ASFLLIKNSSCSES 1155

  Fly  1999 VGSHTKPDDILRSIDKSY-------CDTVLNFLIRLACQVNDPQAPI-----------------L 2039
            .|.:.|....|.|.:.||       .|..|:.|..:...::|||..:                 |
  Fly  1156 EGQNFKEHLQLLSENLSYSQLNATDVDLDLDILCYVISMLHDPQEMMRLFGSLAICNRTASWYSL 1220

  Fly  2040 SPGESLSRRCVMLLKMAMRPEIWPQPFDIKLNWLDKVLATVETPHH--------NLNNICTGIDF 2096
            | ||||. :|   |...:.||:.|. .|.::    :.:.|::|.|.        .|...|....|
  Fly  1221 S-GESLF-KC---LNFHIDPEMRPS-MDSRI----QSMTTLQTKHSRVLVDIFGRLKTNCYSASF 1275

  Fly  2097 LT------FL---------------TTILSPDQLVSIIRPVQRGLSLCIIHQNTRIVRLMHMFLT 2140
            .:      ||               .||::  |....:|.:...:...:||  |:.:|:....||
  Fly  1276 SSQALHDFFLYCEVADAVYDAARKNETIVT--QCSFFVRDIWFFVVRLLIH--TKFIRVQMAALT 1336

  Fly  2141 RIMAIFPPDTQHKH----EDLDLLYTAVSKMIAE-NLTSYEKSPQPNASSLFGTLMILKACTTNN 2200
            .:..:.     :||    :|....:..::|:::. .|....|..:....|:...::..|....|.
  Fly  1337 FLELLL-----NKHNFRLDDYQNHFGDIAKLLSNFQLCCEAKEVREKTMSIVMYILESKKGHINL 1396

  Fly  2201 ASYIDRIL-VQFIRVLNHLTRDHINTIGGNTVISQSPDSNALPLELLVLSLELIKN-RIFVMS-- 2261
            .|:::... .:|::.|    |:...:...|  |.::..:|.|...||..:.|.::: |.::..  
  Fly  1397 NSFLEETTDCEFLKPL----REDCKSSQPN--IDRADVANYLRSFLLSPTPERLRDLRTYIAEHK 1455

  Fly  2262 ---VEIRKLFIGTI--LVSLI----EKSTEVKIIKCIIKMLDEWIKTKEPNVMTQVPSIREKS-- 2315
               .|..||..|.|  |:.:.    .|:|.:..:||:.::....|.|......|...:. |||  
  Fly  1456 DKVQEHEKLLFGVINKLIQMTRDAHNKTTSIDSLKCLAQIGPLKISTVSYYFQTDFEAF-EKSNG 1519

  Fly  2316 ------------ALLVKLMQNVEKKFTDEIELNIQFLEIINFIYRDEILKQTELTNKLEGAFLNG 2368
                        :|...|.|...|.....:.:.||   ::|......|:::          :.|.
  Fly  1520 EPMEAFLGVVCHSLDTSLFQFDPKTHEGLVSVAIQ---VVNSKPGSNIMER----------YKNL 1571

  Fly  2369 LRFQNPNVRSKFFEILDSSMRRRLHDRLLYIICSQAWDTIGSHYWIKQCIELLILTANTMMQIQC 2433
            ..|.:.:..|.|   |.|:.:.|   |:.::...:|..::....|:...:..:......:...:.
  Fly  1572 RIFADKSTASTF---LHSNKQIR---RIDWLSILKATKSLSYEPWMCAFVSKVFQMCGWLGFDKL 1630

  Fly  2434 SNEQFKIPSITSVIPVNSSETQENSFVSFLSSHSESFDIIQTVDDKDDVYDIDLNADRKEDCQQI 2498
            :...|.... |.::|          |:..|..:  |.:.::::....|.:.....:....:.|:|
  Fly  1631 AATSFAFAK-TCLLP----------FIKLLLEN--SLEHVESLSQMLDYFFEGFTSSTAPNSQEI 1682

  Fly  2499 LPNRRVTLVELVYKQAEFLEANRN----IRTDQMLVATSQLCHIDTQLAQSVWLS-MFPRIWSIF 2558
            ..|:|.  ::......|::....|    |....:::|::.        .|:.:|| |:..:|:  
  Fly  1683 FRNKRA--IKKFLHICEYIRIFNNWTIPINLSNVVMASNH--------CQAYFLSIMYLELWA-- 1735

  Fly  2559 TEDQRCNIT-KELIPFLSSGTNVNQKDCHPSTLNTFVESLTKC--APPIYIPP--NLLAYLGKSH 2618
                 |:.: |....||.:       :|.........||: .|  |.|.::.|  :.|.:||...
  Fly  1736 -----CSESPKSKADFLDN-------ECFQDGAKKAYESI-GCLDAIPGFVNPMRSRLDFLGHGS 1787

  Fly  2619 NLWHRAILVLEDMAVNQSMQSKDIDGGENQFSDLDVQQSNNIFDSLSKMYSSMHEEDLWAGLWLK 2683
            ||   :.::||         |..:|....|.. :|:.:.|                    ||| .
  Fly  1788 NL---STILLE---------SDHLDRASGQLC-IDIMKGN--------------------GLW-S 1818

  Fly  2684 FAHYPE-TNIAVSYE---QMGFFEEAQGAYDLAMTKFKQDLSNGVVNTYVNSELLLWENHWMRCA 2744
            ||...: .||...||   ::|.::        ::|..|...:..||.|.::.|.....:|:: ..
  Fly  1819 FAKLQQHQNIEPDYEIFWRLGQWD--------SLTDPKHQQNQTVVRTSLDLEQEFKRHHFV-AL 1874

  Fly  2745 KELNQWDILLDYAQTNKDKNMFLILESSWRVPDWNLMKIALAKTEQCYLKHYGFKINLYKGYLSI 2809
            :.:.|          .:::|....:|.::......||:|::...:..|         .|..:|..
  Fly  1875 RSIGQ----------REEENSLSAIEQAYSCVRDILMEISVECLQSVY---------KYLTWLCS 1920

  Fly  2810 LHQEER----QTGNIERYVEIASSLCI-REWR-----RLPN------IVSH----IHLPYLQASQ 2854
            |.|.|.    |.|.   .::.||:..| |:|:     :..|      :::|    :.|...:||:
  Fly  1921 LQQAEDFCQIQFGT---QLDPASTTKIFRKWQTELELKYGNFSCKEYVIAHQIALLKLAGTRASR 1982

  Fly  2855 QIMELHE----ASQIHQGLAQSRNNSLHDMKAIVKTWRNRLPIISDDLSHWSDIFTWRQHHYQII 2915
            ::.|.::    ::.:.:|:.:.::....::.|........||.|.:.:.            ..::
  Fly  1983 RMSEFYQKDPISTYLMKGIEECKSAGKLNLAAKYTATLRELPNIRESIK------------ISVL 2035

  Fly  2916 TQHLEQQSDQGSTMLGVHASAQAIISFGKIARKHNLTGVCQETLSRIYTIPSVPIVDCFQKIRQQ 2980
            .:..|.....|:..:     |:||:.:  :...:..          :|.:..||      .:|.|
  Fly  2036 LEDAEINLKMGNQQI-----AKAILDY--VTNNNEF----------VYCVQRVP------ALRMQ 2077

  Fly  2981 ----VKCYLQMPSTSGKNEINEALEVIE---------STNLKYFTGEMNAEFYALKGLLLAQIGR 3032
                :.|..:..|....::.|.:|::|:         |...:........:.||.|....|....
  Fly  2078 GEFLLDCNAETLSWVQSHKFNNSLKLIDDFVQHRQTLSEKYRDIFDWHQLDAYASKQRTAAYATI 2142

  Fly  3033 SEEAGKSFSVAAQLHD-GLTKAWAMWGDYMEQIFLKERKITLA--VDALICYLQASR-------- 3086
            ::.|.:.:.   |||| ..::.:....|.:||......|:|..  .|..:..:|..|        
  Fly  2143 AKYADREYQ---QLHDYRHSQEYQTLKDIIEQNRQTAEKVTQRENQDRRVISVQMKRYASLDEQQ 2204

  Fly  3087 -NQIESKTRKYIAKVLW-FLSYDNNTKILISTLEKHVAGIPPSYWLPWIPQLLCCLEQFEGDVIL 3149
             ||||.|..:|:...|. :::|                               |.|:..      
  Fly  2205 LNQIEEKLTEYLRLALTNYMAY-------------------------------CRLDSG------ 2232

  Fly  3150 NLLSQIGRLYPQAVYFPIRTLYLTLKIEQREKHKTAEQAVKSSCSNIDGTTLSFGRGASHGNIPS 3214
                     :..|..:.|.:|:.|     ....|..::.:|....                .:||
  Fly  2233 ---------FSSAAIYRIISLWFT-----NATSKQCQECIKDEIL----------------TVPS 2267

  Fly  3215 INPIKATPPMWRCSKVMQLQREVHPTILSSLEGIVDQMVWFRESWTEEVLRQLRQGLIKCYAIAF 3279
            ...|.|         ..||...::....|.|:|:.|.:|...:........||       |.:.|
  Fly  2268 YKFICA---------ANQLTARLNSKNTSLLKGLTDLLVQCGKDHPYHTFYQL-------YPLVF 2316

  Fly  3280 EKRD----TVQHSTITPHTLHFVKKLGSTFGIGIENVPGSVTSSISNSAASESLARRAQVTFQDP 3340
            ...|    ..:.|.|....:..:.:...|.|              ..|...|||. .|.:||.: 
  Fly  2317 AHLDGENSNTERSGIARKIIAMICEKNGTAG--------------ECSKQLESLL-PALITFAN- 2365

  Fly  3341 VFQKMKEQFTNDFDFSKPGAMKLHN-LISKLKTWIKVLETKVKKLPTSFLIEDKCRFLSNFSQKT 3404
                  |..|||   ::|.:..:.| ...|::.|..:   .....||                  
  Fly  2366 ------EGKTND---NRPVSDSVRNKQFDKVRRWRNL---NAVHCPT------------------ 2400

  Fly  3405 AEVELPGELLIPLSSHYYVRIARFMPRVEIVQKNN--------TAARRLYIRGTNGKIYPYLVVL 3461
              :|||   ::| |..|.:        :.:|:..|        .|..::....::|||...||  
  Fly  2401 --LELP---VMP-SKEYSI--------ISVVKWTNETTQCGGLNAPVKIMCVCSDGKIRAQLV-- 2449

  Fly  3462 DSGLGDARREERVLQLKRMLNYYLEKQKETSRRFLNITVPRVVPISPQMRLAEDNPNSISL---- 3522
             .|..|.|::..:.|:..::|..|.:..|...|.|.:...:|.|:|.:..:.|...||:.:    
  Fly  2450 -KGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGHYL 2513

  Fly  3523 -----------------------------LK--------IFKKCCQSMQVDYDMPIVKYYDRLSE 3550
                                         ||        |:||.|::::                
  Fly  2514 VVEGKGGAHARYRPNDWNNNKCRKLSSDHLKSPKETRYAIYKKICENIK---------------- 2562

  Fly  3551 VQARGTPTTHTLLREIFSEIQWTMVPKTLLKHWALKTFLAATDFWHFRKM-LTLQLALAFLCEHA 3614
                  |..|..|.|.|.      :|                ..|..|:: .|..:|...:..:.
  Fly  2563 ------PVFHYFLLEKFP------IP----------------GVWFERRLAYTNSVATTSMVGYV 2599

  Fly  3615 LNL-TRLNADMMYLHQDSGLMNISYFKFDVNDDKCQLNQHRPVPFRLTPNVGEFITHFGITGPLS 3678
            |.| .|...:::...|.:.:::|. |.......|.|... ..||||||   .:|:...||.|...
  Fly  2600 LGLGDRHTQNILVDQQTAEVIHID-FGIAFEQGKIQTTP-ETVPFRLT---RDFVAPMGICGTKG 2659

  Fly  3679 A-AIVATARCFIQPNYK--LSSILQTILRDEII---ALQKKGFRECKLIEGSEDRYSDGNCMEHS 3737
            . |....|...|...||  .::||:.:|.|.:.   .|:||              .|.....|.|
  Fly  2660 VFAKSCEATMHILRRYKSVFTTILEVLLYDPLFIWGVLKKK--------------QSPQQSGEES 2710

  Fly  3738 VNIVNSAVDIIMTRFNKI------SYFDSIENKKISVLVQSATNIDNLCRMDPAWHPWL 3790
            ||:|.....:::.  ||:      :..||....::..|:..||...|||.:.|.|.|.|
  Fly  2711 VNLVAQRALLLVQ--NKLDGREAGTMGDSNVEAQVERLINEATLPSNLCMLFPGWDPHL 2767

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nipped-ANP_001097192.2 Tra1_central 270..848 CDD:466326 47/212 (22%)
Tra1_ring 859..2600 CDD:466357 342/1962 (17%)
FAT 2767..3102 CDD:396714 67/383 (17%)
PIKK_TRRAP 3425..3712 CDD:270707 67/343 (20%)
FATC <3769..3790 CDD:460514 9/20 (45%)
tefuNP_001036712.1 FAT 1829..>2064 CDD:396714 45/284 (16%)
PIKKc_ATM 2416..2696 CDD:270715 66/331 (20%)
FATC 2739..2767 CDD:460514 9/27 (33%)

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