Protein Alignment Nipped-A and mei-41

DIOPT Version :9

• Sequence 1: NP_001097192.2
• Gene: Nipped-A / 35483
• FlyBaseID: FBgn0053554
• Length: 3790
• Species: Drosophila melanogaster
• Sequence 2: NP_523369.2
• Gene: mei-41 / 32608
• FlyBaseID: FBgn0004367
• Length: 2517
• Species: Drosophila melanogaster
• Alignment Length: 3165
• Identity: 560/3165 - (17%)
• Similarity: 1000/3165 - (31%)
• Gaps: 1148/3165 - (36%)

  Fly  1106 SKVGGCQAI--QFLCKHMSL--RALFQNLFN-FLKAFMFVLMD------LEGDVSNGAIEITKSY 1159
            |...|..::  ..||:..||  .:|.:.|.| |...|:..|::      .|...|:..|.:.:..
  Fly    21 SNFSGVYSVIEDILCQEPSLISCSLVRELHNKFQDTFLLWLLNKLAKCLSESPDSSECINLQRKI 85

  Fly  1160 MKSMLEICLTPINECYKNIDLKDLQAKATYEVIHELVRHITSPN--TIVREESMVLLKHIGTIQS 1222
            :.|    |      |..:..|.:....|..|.|.|....::|.:  .:..|....:...|.....
  Fly    86 LSS----C------CSNHPKLFERLVLAYVEAIEETHLQLSSLDLGQLSNERKPAITVRIFRCDV 140

  Fly  1223 KTVSEVMDPHKDVLADIIPP-------KKHLLRHQPANAQIG-LMDGNTFCTTLEPRLFTIDLTN 1279
            :.:.| .||| ..:.||..|       .|.||........|| ...|:.|..:|
  Fly   141 ECLQE-FDPH-CAIEDIKVPLEQADMYAKSLLEVLQHAHHIGYATHGDIFSGSL----------- 192

  Fly  1280 TYHKLFFHE-LLTLSEAE-DATLAKLDCYKNVPNLIPLRTSALRALAACHYIS--DIGYKEKIIN 1340
                   |: ||.|.|.: |..||.|:...||          ||:.:|..:|:  |:|:..::
  Fly   193 -------HQALLILKECDMDTKLASLNYCHNV----------LRSQSASSWITNPDVGHYAQL-- 238

  Fly  1341 IIFKVMESDKSELQTTA-----------FHCMKHFITGVTLEKEKVQSAMRPLLLKLGDHRNLSI 1394
                       .|:.||           ..||       |.::.|..:....|||::...|  :.
  Fly   239 -----------TLEATAIMWSAVAKWLDMGCM-------TRQELKRLNITTKLLLEVLHMR--AR 283

  Fly  1395 PAIKRLSYFTQIFPQMFNE--------KLSEQILQHCSKIMEIFVSEYKSTSPNVNFFASSKGGE 1451
            || ..|.|.      :.||        :|.:.:|:..|..::                     |:
  Fly   284 PA-HHLGYL------LLNEILSLPTAIELDDGLLETLSSYIQ---------------------GQ 320

  Fly  1452 YEQKIVILIEMFFYISASVKYIEKLCQLVLKTEKNLMIEASSPYREALIKFLQRFPTETVDL--- 1513
            .|..:|.|              |:|..|     :.||:.....:...|:..|.....:..::
  Fly   321 LEHSVVPL--------------EQLVHL-----QQLMLSHWHCHPTHLVPILALMGLKQTEMRSG 366

  Fly  1514 ---FLTESLMIDPQWNRLFIYLLKHETGVSFRAVIKSSRYNNLIHYLNTHTEFPEALKYEIQHQ- 1574
               .||:||          :.:||.|.       :.|..:..||..|....:..:.:..:.||:
  Fly   367 VVQVLTQSL----------VEILKKEE-------VLSKDWQKLIAILRGFKQLEKLILSQSQHKI 414

  Fly  1575 ---------AVLIIFTLMESDDQWIPTRQDIVDALKNCWQNYLSTLSSEDVLC--DLWHL---IG 1625
                     :||.:          :|.:.:|:......|.|....|...:..|  |..|:   |.
  Fly   415 AEHEGHIDSSVLAM----------LPLQCEIIKVADTNWNNLSMQLVELESKCSADRRHIHLEIC 469

  Fly  1626 KILL------HYFSNNTNDIELLFQLLRALCFRFIPDVYFLRDFLQHTVAQSFTVNWKRNAFFYF 1684
            .:|:      |:....|.. :||..|.|.|...::..:........||..|||           :
  Fly   470 SLLMQITFIRHFLKTQTQH-QLLAILQRHLKLSYLCAIRLETPSSVHTQMQSF-----------Y 522

  Fly  1685 VENFNNSFLSEELKAKIITAVIIPCFAVSFDKGEGNKLIGAPPTPYQE------------DEKNI 1737
            .:.:...|.|||.: :|..:.:...:...|.|.|  :|:.|.||....            .:...
  Fly   523 AQQYMRLFQSEETQ-EIFCSNLPQLYISGFIKPE--QLMKALPTINNRSGRAQVIRLLLCSQPGK 584

  Fly  1738 VSVFINKVFDPDKQYDDAVRIALLQLACLLVERASQHIHDGD---ANNKRQGNKLRRLMTFAWPC 1799
            :|||  ||.|..:.|....|....:|..:.:.:..|.:...|   .|.:...|.|  |....:.|
  Fly   585 LSVF--KVKDRIELYCPKCRPLPKKLPGIYLGKCKQQLPCPDFSSTNLEMIANDL--LFYPDFEC 645

  Fly  1800 L-----------------------LSKSSVDPTARYHGHLLLSHIIARLAIHK--------KIVL 1833
            :                       |.|.||.         ::..:::.:.:..        .:||
  Fly   646 IAQHLDLLCFEPNVILGLLRETEALQKVSVK---------VIGQLVSAMRVRSPEFLEQLANLVL 701

  Fly  1834 QVFHSLL-----KGHALEARSIVKQALDVLTPAMPLRMEDGNTMLTHWTKKIIVEEGHAMQQLFH 1893
            ....::|     :.:.|:.||:    |:|||..  ..|||....|.||.|
  Fly   702 AAIKAMLAKPLTEQNVLQQRSM----LNVLTAI--AHMEDNEIWLFHWFK--------------- 745

  Fly  1894 ILQLIIRHYKVYFPVRHQLVQHLINYMQRLGFPPTASIEHKKLAVDLAEV--------IIKWELH 1950
                     ..:|.:.|                 |.|:..::..:...|:        |..|..:
  Fly   746 ---------MTFFFLVH-----------------TRSLVAQEAVLAATEMCASQGLQTIHLWNWY 784

  Fly  1951 RIKDDRETKTDGTEEELIQESSVKRSGIDLVETRKKSFDIIRETTVQGVGSHTKPDDILRSIDKS 2015
                                   ||..:||.
  Fly   785 -----------------------KRDALDLT---------------------------------- 792

  Fly  2016 YCDTVLNFLIRLACQVNDPQAPILSPGESLSRRCVMLLKMAMRPEIWPQPFDIKLNWLDKVLATV 2080
                     :|||..|      .|..|...:|....|.||.....:  |.|..|.:   ::|..:
  Fly   793 ---------VRLALNV------YLLDGVRFTRSLRALTKMLGFTCV--QEFTCKYH---RLLTAM 837

  Fly  2081 ETPHHNLNNICTGIDFLTFLTTILSPDQLVSIIRPVQRGLSLCIIHQNTRIVRLMHMFLTRIMAI 2145
            ..||..:|.:|.|:              ||.|.:.:|:.:.........||  ..|:|||.
  Fly   838 VLPHCIVNPLCKGV--------------LVLIAKQMQKHIGTLFSISFLRI--YTHVFLTE---- 882

  Fly  2146 FPPDTQHKHEDL----------DLLYTAVSKMIAENLTSYEKSP-------QPNASSLFGTLMIL 2193
             .|:..:...:|          .|:...|.:.:||.|..:.::|       |.......|:|..|
  Fly   883 -EPELANSCIELVVSCTQSSLQQLMNADVKQTVAELLIYFNRNPTFVMRSFQSLLQLSIGSLEEL 946

  Fly  2194 KACTTNNASYIDRILVQFIRVLNHLTRDHINTIGGNTVISQSPDSNALPLELLVLSLELIKNRIF 2258
            .: .|.||.:.:.|..:|:.|:.:.          .:.:|:......|..|.|....::::   |
  Fly   947 SS-QTANAEFANFIAERFLGVITYF----------ESCLSEPSFEKPLKEETLYSLGQIMR---F 997

  Fly  2259 VMSVEIRKLFIGTI-LVSLIEKSTEVKIIKCIIKMLDEWIKTKEPNVMTQVPSIREKSALLVKLM 2322
            |.|..:.:.....| ::|.:....|.::.:..:|:   |      ::...|.:::|....|.:::
  Fly   998 VGSQHVTQFRFKIIAMLSFVHTLQEPRLQRICLKI---W------HIFLHVVNVQELGPSLGRIV 1053

  Fly  2323 QNVEKKFTDEIELNIQFLEIINFIYRDEILKQTELTNKLEGAFLNGLRF--QNPNVRSKFFEILD 2385
            ..::....|.     :.::.:|.:|...||:...:.    |.|:..|.|  :..||...    :.
  Fly  1054 ATLQPLLADN-----ESVKQVNDLYEFIILRNASML----GTFITDLYFLDRMENVSPS----IQ 1105

  Fly  2386 SSMRRR------------------LHDRLLYIICSQAWDTIGSHYWIKQCIELLILTANTMMQIQ 2432
            ..:||.                  |.|:|.::          ..:...:|:::.:..      :|
  Fly  1106 KCIRRHTAHLDLKGLAEEENQSPPLVDQLRFL----------QKHITDECLQVRVYA------LQ 1154

  Fly  2433 CSNEQF--KIPSITSVIPVNSSETQENSFVSFLSSHSESFDIIQTVDDKDDVYDIDLNADRKEDC 2495
            ...:.|  :.|.:.|.|            :|.|........|:..           |.|..:.|.
  Fly  1155 HLGDLFGRRRPKLNSTI------------LSELPLEPMLEQIVNV-----------LMAGCQHDD 1196

  Fly  2496 QQILPNRRVTLVELVYKQAEFLEANRNIRTDQML-----------VATSQLC----------HID 2539
            .|:.......|.||....|.:|.:|.|..:.|.|           :|.:.||          |:|
  Fly  1197 SQLQMASAKCLGELGAIDASYLPSNYNFASPQHLPLNILSDDFAVLALTSLCRGYQFQQNTKHVD 1261

  Fly  2540 T------------------QLAQSVWLS--------MFPRIWSIFT---EDQRC----------- 2564
            :                  |....:|.|        |.|.:.|.:|   ....|
  Fly  1262 SFSLAIQETLAICGISPKEQKKVQLWQSLPARMRQLMEPMLHSCYTCVHRPSTCLQQPLFGSHYS 1326

  Fly  2565 -NITKE--------LIPFL-SSGTN---VNQKDC---HPSTLNTF-----VESLTKCAPPIYIPP 2608
             |..:|        ||.:| |||..   .:.|.|   ..:.|:||     :.:|.:|...
  Fly  1327 HNYYEEWAFLWASRLIDYLPSSGRRHLLSSYKPCIKRDSNMLSTFYPYILLHALLECTTE----- 1386

  Fly  2609 NLLAYLGKSHNLWHRAILVLEDMAVNQSMQ--SKDIDG-------GENQFSDLDVQQSNNIFDSL 2664
                         .|..:..|.|||.|:.:  |..:.|       .||.|...:.::.......|
  Fly  1387 -------------QRNHIQEEFMAVLQANEESSSSVRGRQELGAIKENAFKQFESRKYAAGIKPL 1438

  Fly  2665 SKMYSSMHEED--------------------LWAGLWLKF------AHYPET------------N 2691
            :....|..:||                    .|...|.:.      ...|||            |
  Fly  1439 ASTLVSDRKEDSSRVPRLAGKLCAELLDFLQRWLREWQRIHGRSTGGKPPETIDSNYRKIHEFLN 1503

  Fly  2692 I------------------AVSY----------------EQMGFFEEAQG--------------- 2707
            :                  |:||                ||..|..|..|
  Fly  1504 LIPKLLVSRASYNCGEYARALSYLESYLEEGEDKSQRLLEQFTFLVEVYGSLRDPDSVEGAVQVR 1568

  Fly  2708 AYDLAMTKFKQDLSNGVVNTYVNSELLLWENHWMRCAKELNQWDILLDYAQ-------------- 2758
            :||:::|   ||:   :||..|.                 .|.|::..|.|
  Fly  1569 SYDMSVT---QDI---LVNRLVE-----------------RQQDMITSYEQLLSSTDQMQPDHVR 1610

  Fly  2759 -------TNKDKNMFLILESSWRVPDWNLMKIALAKTEQCYLKHYGFKINLYKGYLSILHQEERQ 2816
                   .:..|...||.:..|:       :::...::||:.:   .|..|.....|....||.|
  Fly  1611 AMIDAYLRDTPKTAQLIADGLWQ-------RLSDRYSDQCFAE---CKSELLWRLGSYDEMEELQ 1665

  Fly  2817 TG--------------NIERYVEIASSL------CIREWRRLPNIVSHIHLPYLQASQQIMELHE 2861
            :.              .:...:|..|.|      .:.|.|....:..|   .|..|...:::||.
  Fly  1666 SNWPAQCSQGCLKLRRPLTTRIEFDSLLDGMRESVLEELRSCSAVQQH---SYANAYDAVLKLHL 1727

  Fly  2862 ASQIH------QGLAQSRNNSLHD--MKAIVKTWRNRLPIISDDLSHWSDIFTWRQHHYQIITQH 2918
            ..::|      :.|.|.|:....:  ||.....|:.||.|:...:.....|:::|::   |:.:.
  Fly  1728 VHELHCSQELVEKLEQDRDEDNQEKLMKNYFDDWQYRLQIVQPQVRIQESIYSFRRN---ILAEL 1789

  Fly  2919 LEQQSDQGSTMLGVHA--------SAQAIISFGKIARKHNLTGVCQETLSRIYTI------PSVP 2969
            ..:.:|:...:..:..        |||...:.|::.|            :::|.:      ||..
  Fly  1790 QRRLTDRNHLLPHLKTELARIWLNSAQINRNAGQLQR------------AQLYILKAAEYQPSGL 1842

  Fly  2970 IVDCFQKIRQQVKCYLQMPSTSGKNEINEALEVIES---TNLKYFTGEMNAEFYALKGLLLAQIG 3031
            .::..:.:.|:....:.|      |.:.|.|.::.|   .|:|....|....|:.
  Fly  1843 FIERAKLLWQKGDQVMAM------NYLEEQLSIMRSGCQGNVKQLAAEQRHLFFR---------- 1891

  Fly  3032 RSEEAGKSFSVAAQLHDGLTKAWAMWGDYMEQIFLKERKITLAVDALICYLQ---ASRNQIES-- 3091
                                      |.|::.::..| .:.|..||::.|.|   |...|.||
  Fly  1892 --------------------------GKYLQAVYSAE-SMHLCADAVLKYFQEAIAVHRQSESCH 1929

  Fly  3092 -KTRKYIAKVLWFLSYDNNTKILISTLEKHVAG-IPPSYWLPWIPQLLCCLEQFEGDVILNLLSQ 3154
             :..:::.|:                ||....| ..|:.            ||  .|:::|::..
  Fly  1930 VQMAQFLEKI----------------LEARQGGKSEPTG------------EQ--DDMLINVMVN 1964

  Fly  3155 IGRLYPQAVYFPIRTLY------LTLKIEQREKHKTAEQAVK-----SSCSNIDGTTLSFGRGAS 3208
                |.:::.:....:|      ::|.::..|.....||..|     ::|.....|.:.:
  Fly  1965 ----YAKSLRYGSEHVYQSMPRLISLWLDTTESSTNTEQVKKMNDLLTNCCTALPTAVFY----- 2020

  Fly  3209 HGNIPSINPIKATPPMWRCSKVMQLQREVHPT--ILSSLEGIVDQMVWFRESWTEEVLRQLRQGL 3271
              .:.|                ..|.|..||.  :.:.|..::.::|   |::.::.|..|
  Fly  2021 --TVYS----------------QMLSRLCHPVNDVFTVLRNVIIKLV---EAYPQQSLWML---- 2060

  Fly  3272 IKCYAIAFEKRDTVQHSTITPHTLHFVKKLGSTFGIGIENVPGSVTSSISNSAASESLARRAQV- 3335
                               .||                           ..||.:..:.|...|
  Fly  2061 -------------------LPH---------------------------FKSAKAHRIKRCKLVL 2079

  Fly  3336 ---TFQDPVFQKMKEQFTNDFDFSKPGAMKLHNLISKLKTWIKV--LETKVKKLPTSFLIEDKCR 3395
               ..|:..|||:.:    ||:......|.|.|....|....|:  |:|::.||         |:
  Fly  2080 TDSRLQNSTFQKLLQ----DFNSLTERLMDLTNKEVTLDRTYKLSDLDTRLSKL---------CK 2131

  Fly  3396 FLSNFSQKTAEVELPGELLIPLSS---------------------HYYVRIARFMPRVEIVQKNN 3439
             ...|||.....|...:..:||:|                     :..:.|:.|...| ::.::.
  Fly  2132 -QPEFSQILLPFEKYMQPTLPLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQESV-LILRSA 2194

  Fly  3440 TAARRLYIRGTNGKIYPYLVVLDSGLGDARREERVLQLKRMLNYYLEKQKETSRRFLNITVPRVV 3504
            ...::|.||.::||.|..||   ....|.||:.|:::...::..||.:.....:|.|:|....|:
  Fly  2195 AKPKKLTIRCSDGKDYDVLV---KPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVL 2256

  Fly  3505 PISPQMRLAEDNPNSISLLKIFKKCCQSMQVDYDMPIVKYYDR-----LSEVQARGTPTTHTL-- 3562
            |.:.:..|.|..||    |..::..|.::          |..|     ..::|:...|...::
  Fly  2257 PFNEECGLVEWLPN----LASYRSICMNL----------YAQRRLVMSTRQLQSLAVPLHESIER 2307

  Fly  3563 LREIFSEIQWTMVP--KTLLKHWALKTFLAATDFWHFRKMLTLQLALAFLCEHALNL-TRLNADM 3624
            .||:|::   .:||  ..:.:.|..:.|.....::..|......:|:..:..:.|.| .|...::
  Fly  2308 KREVFTK---QLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENI 2369

  Fly  3625 MYLHQDSGLMNISYFKFDVNDDKCQLNQ------HRPVPFRLTPNVGEFITHFGITGPLSAAIVA 3683
            ::...:...:::        |..|..||      ...||||||.|:...:...|:.|........
  Fly  2370 LFAEGNGDAVHV--------DFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEI 2426

  Fly  3684 TARCFIQPNYKLSSILQTILRDEIIALQKKGFRECKL---IEGSEDRYSDGNCMEHSVNIVNSAV 3745
            |.|...|.:..|.|||:..:.| :.|..:||....|:   ::...||. .|:......|.:..:.
  Fly  2427 TLRLLKQESKTLMSILRPFVYD-VGAQTRKGAATAKITKDVQRIADRL-QGHVKRQQANSIPLST 2489

  Fly  3746 DIIMTRFNKISYFDSIENKKISVLVQSATNIDNLCRMDPAWHPWL 3790
            :                 .:::.|:..||.:|||..|...|..:|
  Fly  2490 E-----------------GQVNFLINEATKVDNLASMYIGWGAFL 2517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nipped-A	NP_001097192.2	FRB_dom	<2568..3790	CDD:331513	259/1469 (18%)
		FAT	2767..3102	CDD:308074	66/385 (17%)
		PIKK_TRRAP	3425..3712	CDD:270707	66/302 (22%)
mei-41	NP_523369.2	UME	955..1060	CDD:214825	18/126 (14%)
		FAT	1653..1985	CDD:280429	69/426 (16%)
		PIKKc_ATR	2181..2448	CDD:270625	64/295 (22%)
		FATC	2486..2517	CDD:280430	8/47 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464452
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11139
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030