DRSC/TRiP Functional Genomics Resources

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Protein Alignment Atf6 and CREB3L1

DIOPT Version :9

Sequence 1:NP_995745.1 Gene:Atf6 / 35480 FlyBaseID:FBgn0033010 Length:741 Species:Drosophila melanogaster
Sequence 2:NP_443086.1 Gene:CREB3L1 / 90993 HGNCID:18856 Length:519 Species:Homo sapiens


Alignment Length:570 Identity:114/570 - (20%)
Similarity:200/570 - (35%) Gaps:186/570 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 DINEYNLYNDLSL---LGEVTEN--NYDNNIVHDILNSSAFYNDTSLD---------LSELIPDL 52
            |:||.:..|:...   |...|||  ::.|::.      |:|::|..||         |....|.:
Human    24 DLNESDFLNNAHFPEHLDHFTENMEDFSNDLF------SSFFDDPVLDEKSPLLDMELDSPTPGI 82

  Fly    53 QKE-AFGLHFSSNPITSEFSLSSPISGLKQIPSA--------------CSGEFKRNVNDNNFQLD 102
            |.| ::.|...|.|       .||:..:|...:.              ||...|:..:.      
Human    83 QAEHSYSLSGDSAP-------QSPLVPIKMEDTTQDAEHGAWALGHKLCSIMVKQEQSP------ 134

  Fly   103 LTNSRNDLP-EPNSSPTRSLNRSNVNGCSNEEAVYPLLVDSDKFDPFFE-PAKVRSPNKEFNSTI 165
                  :|| :|.::|       :....:...|..|||    ...|... |...::|.:     :
Human   135 ------ELPVDPLAAP-------SAMAAAAAMATTPLL----GLSPLSRLPIPHQAPGE-----M 177

  Fly   166 SNLSDIKNELPETSQDLGF-------------NSYNTSRNNSTLTKSWPINTELNLDNQVPKTVL 217
            :.|..||.|..|.:|.|..             :|:.:..:.|...:|.|.::          .|.
Human   178 TQLPVIKAEPLEVNQFLKVTPEDLVQMPPTPPSSHGSDSDGSQSPRSLPPSS----------PVR 232

  Fly   218 PLSRT--------IYLPSHDYKGLLPTVKCNGDRTLKKNVNVRSKISNIVIKKKNATFIQS---L 271
            |::|:        :....|..:|....:                    ::.:::..|.|..   :
Human   233 PMARSSTAISTSPLLTAPHKLQGTSGPL--------------------LLTEEEKRTLIAEGYPI 277

  Fly   272 KESTPSHTMDDKIYKKYQRMIKNRESASLSRKKRKEYVVSLETRI-------NKLEKECDSLKAE 329
            ....|....::|..|:.:|.|||:.||..||:|:||||..||.::       |:|.|:.::|:..
Human   278 PTKLPLTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEKKVETFTSENNELWKKVETLENA 342

  Fly   330 NITLRDQIFLLATSCQRESGNANGLLHNYSGSERSENKNGRFTSKAKHCNKNNTTATIKKNVAIL 394
            |.||..|:..|.|                           ..|:|.....|...|.|  ....::
Human   343 NRTLLQQLQKLQT---------------------------LVTNKISRPYKMAATQT--GTCLMV 378

  Fly   395 FAMAFVVSLNAGNFQKYLNIPNNLEGKSEI--EPVGKQ-----LSMSNRRLLWADSEEEYKEKNN 452
            .|:.||:.|  |:....|  |....|...:  :|:...     ..|.:|.||:.|......| :.
Human   379 AALCFVLVL--GSLVPCL--PEFSSGSQTVKEDPLAADGVYTASQMPSRSLLFYDDGAGLWE-DG 438

  Fly   453 LSTFLSGKQKEPSLYFLNSG----------IRNHKINSFENITKNVSHTY 492
            .||.|  ..:.|..:.:|.|          :::..::|....||.:|..:
Human   439 RSTLL--PMEPPDGWEINPGGPAEQRPRDHLQHDHLDSTHETTKYLSEAW 486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atf6NP_995745.1 bZIP_ATF6 287..338 CDD:269848 23/57 (40%)
coiled coil 287..338 CDD:269848 23/57 (40%)
CREB3L1NP_443086.1 Required for transcriptional activation 1..60 11/41 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 71..98 7/33 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 200..259 9/68 (13%)
bZIP_CREB3 291..344 CDD:269837 20/52 (38%)
Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 292..321 16/28 (57%)
coiled coil 293..344 CDD:269837 19/50 (38%)
Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 332..353 7/20 (35%)
S2P recognition. /evidence=ECO:0000303|PubMed:21767813 392..395 1/4 (25%)
S1P recognition. /evidence=ECO:0000303|PubMed:21767813 423..426 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 484..519 0/3 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144439
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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